[1]郭俊林,张立.BNP对CRT后期疗效的临床评价[J].医学信息,2018,(01):67-69.[doi:10.3969/j.issn.1006-1959.2018.01.024]
 GUO Jun-lin,ZHANG li.Clinical Evaluation of BNP in Treatment of Late CRT[J].Medical Information,2018,(01):67-69.[doi:10.3969/j.issn.1006-1959.2018.01.024]
点击复制

BNP对CRT后期疗效的临床评价()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2018年01期
页码:
67-69
栏目:
论著
出版日期:
2018-01-01

文章信息/Info

Title:
Clinical Evaluation of BNP in Treatment of Late CRT
文章编号:
1006-1959(2018)01-0067-03
作者:
郭俊林1张立2
1.四川省广安市人民医院/四川大学华西广安医院,四川广安638000曰 2.四川大学华西医院心内科,四川成都610041
Author(s):
GUO Jun-lin1ZHANG li2
1.Guang'an People's Hospital of Sichuan Province/Guang'an Hospital of West China,Sichuan University,Guang'an 638000,Sichuan, China; 2.Department of Cardiology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan,China
关键词:
心力衰竭心脏再同步化治疗心脏功能BNP超声心动描记术
Keywords:
Key words:Heart failureCardiac resynchronization therapyCardiac functionBNPEchocardiography
分类号:
R541
DOI:
10.3969/j.issn.1006-1959.2018.01.024
文献标志码:
A
摘要:
目的观察B-型脑钠肽(brain natriuretic peptide,BNP)对心脏再同步化起搏器治疗慢性心功能不全(chronic heart failure,CHF)的临床评价遥方法选择2010 年3 月~2017 年1 月于我院顺利完成心脏再同步化治疗的慢性心功能不全患者46 例遥在治疗前及治疗后6 个月,对患者进行NYHA分级标准评估,通过采取心脏超声来对相应患者的LVEF(左室射血分数), LVESVI(左室收缩末期容量指数)相关指数进行评价,并且采取酶联免疫法(Enzyme-linked immunosorbent assay, ELISA)测定 研究对象手术前后BNP 的表达水平,随后运用统计学软件分析检验结果遥结果终点观察达到6 个月,研究对象LVEF, LVESVI 及心脏功能NYHA分级标准均较治疗前明显表达上调,且有统计学差异(<0.05)曰患者BNP 的浓度较治疗前显著降 低,且有统计学差异(<0.05)遥结论CRT 明显改善慢性心衰的心功能,通过检测患者BNP水平可对其做出有效评价遥
Abstract:
Abstract:Objective To observe the clinical evaluation of B-brain natriuretic peptide (BNP)in the treatment of chronic cardiac insufficiency (chronic heart failure)with cardiac cardiac(cardiac resynchronization therapy).Methods From March 2010~2017 year in January in our hospital,the successful completion of cardiac resynchronization therapy of the patients with chronic heart failure in 46 cases.In 6 months before and after treatment,the patients were evaluated by NYHA grading standards,LVEF (LVEF)and LVESVI (relative index of left ventricular end-systolic index)of the corresponding patients were evaluated by using echocardiography.Enzymelinked immunosorbent assay(ELISA)BNP expression level before and after surgery, and then use the statistical software analysis of test results.Results The end point of observation reached 6 months, the study objects LVEF,LVESVI and cardiac function NYHA grade were significantly higher than the treatment of expression,and there was a significant difference ( <0.05);patients with BNP concentrations were significantly lower than before treatment,and statistically difference ( <0.05). Conclusion CRT significantly improves cardiac function in patients with chronic heart failure,which can be effectively assessed by measuring BNP levels in patients.

参考文献/References:

[1]European Society of Cardiology (ESC),European Heart Rhythm Association (EHRA),Brignole M,et al.2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy:The Task Forceon cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC) [J].Eu- ropace,2013,15(8):1070-1118.
[2]Knackstedt C,Arndt M,Mischke K,et al.Depression,psycho- logical distress,and quality of life in patients with cardioverter defibrillator with or without cardiac resynchronization therapy [J].Heart Vessels,2014,29(3):364-374.
[3]Slyngstad T,Huth Ruwald AC,Kutyifa V,et al.Cardiac resyn- chronization therapy is associated with reductions in left atrial volume and inappropriate implantable cardioverter-defibrillator therapy in MADIT-CRT [J].Heart Rhythm,2014,11(6):1001- 1007.
[4]中华医学会心血管病学分会,中华心血管病杂志编辑委员 会.中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志, 2014,42(2):98-122.
[5]De Boeck BW,Teske AJ,Meine M,et al.Septal rebound stretch reflects the functional substrate to cardiac resynchroniza- tion therapy and predicts volumetric and neurohormonal re- sponse[J].Eur J Heart Fail,2009,11(9):863-871.
[6]Felker GM,Anstrom KJ,Adams KF,et al.Effect of Natriuretic Peptide-Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Re- duced Ejection Fraction:A Randomized Clinical Trial[J].JAMA. 2017,318(8):713-720.
[7]Leenders GE,De Boeck BWL,Teske AJ,et al.Septal Rebound Stretch is a Strong Predictor of Outcome After Cardiac Resyn- chronization Therapy [J].J Card Fail,2012,18(5):404-412.
[8]Oeing CU,Tschpe C,Pieske B.The new ESC Guidelines for acute and chronic heart failure 2016[J].Her,2016,41(8):655-663.
[9]Swets JA.Measuring the accuracy of diagnostic systems[J].Sci- ence,1988(240):1285-1293.
[10]Chen JY,Lin KH,Chang KC,et al.The Shortest QRS Dura- tion of an Electrocardiogram Might Be an Optimal Electrocar- diographic Predictor for Response to Cardiac Resynchronization Therapy[J].Int Heart J,2017,58(4):530-535.

相似文献/References:

[1]程 林.重组人脑利钠肽用于重症急性心肌炎伴 心力衰竭患者治疗的临床研究[J].医学信息,2018,(08):126.[doi:10.3969/j.issn.1006-1959.2018.08.042]
 CHENG Lin.Clinical Study of Recombinant Human Brain Natriuretic Peptide in the Treatment of Patients with Severe Acute Myocarditis and Heart Failure[J].Medical Information,2018,(01):126.[doi:10.3969/j.issn.1006-1959.2018.08.042]
[2]胡丽君.螺内酯联合曲美他嗪治疗慢性心力衰竭的疗效分析[J].医学信息,2018,(08):131.[doi:10.3969/j.issn.1006-1959.2018.08.044]
 HU Li-jun.Efficacy of Spironolactone Combined with Trimetazidine in the Treatment of Chronic Heart Failure[J].Medical Information,2018,(01):131.[doi:10.3969/j.issn.1006-1959.2018.08.044]
[3]李 铎,王建华.盐酸曲美他嗪片辅助治疗对冠心病伴心力衰竭患者氧化应激、心肌功能的影响[J].医学信息,2018,(10):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
 LI Duo,WANG Jian-hua.Effect of Trimetazidine Hydrochloride Tablets Adjuvant Therapy on Oxidative Stress and Myocardial Function in Patients with Coronary Heart Disease Complicated with Heart Failure[J].Medical Information,2018,(01):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
[4]何玲玲,程淑芬.曲美他嗪联合琥珀酸美托洛尔治疗冠心病心力衰竭疗效观察[J].医学信息,2018,(13):142.[doi:10.3969/j.issn.1006-1959.2018.13.042]
 HE Ling-ling,CHENG Shu-fen.Therapeutic Effect of Trimetazidine Combined with Metoprolol Succinate in the Treatment of Coronary Heart Disease with Heart Failure[J].Medical Information,2018,(01):142.[doi:10.3969/j.issn.1006-1959.2018.13.042]
[5]赵 维,廖荣宏,王爱华.糖皮质激素治疗心力衰竭疗效与安全性的Meta分析[J].医学信息,2018,(14):70.[doi:10.3969/j.issn.1006-1959.2018.14.021]
 ZHAO Wei,LIAO Rong-hong,WANG Ai-hua.Meta-analysis of the Efficacy and Safety of Glucocorticoids in the Treatment of Heart Failure[J].Medical Information,2018,(01):70.[doi:10.3969/j.issn.1006-1959.2018.14.021]
[6]施国富,吴春阳,施亚明,等.血浆脑钠肽对射血分数保留心力衰竭患者的诊断价值研究[J].医学信息,2018,(16):47.[doi:10.3969/j.issn.1006-1959.2018.16.013]
 SHI Guo-fu,WU Chun-yang,SHI Ya-ming,et al.Diagnostic Value of Plasma Brain Natriuretic Peptide in Patients with Heart Failure Preserved by Ejection Fraction[J].Medical Information,2018,(01):47.[doi:10.3969/j.issn.1006-1959.2018.16.013]
[7]李 宁,胡硕强.心脏再同步治疗心力衰竭的文献计量分析[J].医学信息,2018,(19):79.[doi:10.3969/j.issn.1006-1959.2018.19.024]
 LI Ning,HU Shou-qiang.Bibliometric Analysis of Cardiac Resynchronization in the Treatment of Heart Failure[J].Medical Information,2018,(01):79.[doi:10.3969/j.issn.1006-1959.2018.19.024]
[8]颜 琼,王 静,胡 聪.慢性心力衰竭患者半年内重返住院的调查分析与对策[J].医学信息,2018,(20):173.[doi:10.3969/j.issn.1006-1959.2018.20.055]
 YAN Qiong,WANG Jing,HU Cong.Investigation and Countermeasures of Patients with Chronic Heart Failure Returning to Hospital within Half a Year[J].Medical Information,2018,(01):173.[doi:10.3969/j.issn.1006-1959.2018.20.055]
[9]杨锦龙,刘 欢.甲状腺激素测定在高血压心力衰竭患者中的临床意义[J].医学信息,2018,(22):96.[doi:10.3969/j.issn.1006-1959.2018.22.026]
 YANG Jin-long,LIU Huanc.Clinical Signifcance of Changes of Serum Thyroid Hormone Levels in Hypertensive Patients with Chronic Heart Failure[J].Medical Information,2018,(01):96.[doi:10.3969/j.issn.1006-1959.2018.22.026]
[10]聂今心,丁振江,段华莹.心力衰竭患者血清脑钠肽和白蛋白相关性分析[J].医学信息,2019,(05):98.[doi:10.3969/j.issn.1006-1959.2019.05.029]
 NIE Jin-xin,DING Zhen-jiang,DUAN Hua-ying.Correlation between Serum Brain Natriuretic Peptide and Albumin in Patients with Heart Failure[J].Medical Information,2019,(01):98.[doi:10.3969/j.issn.1006-1959.2019.05.029]

更新日期/Last Update: 2018-01-22