[1]徐闪闪,梁 杰,郑晓艳,等.2015-2019年扬州市疑似预防接种异常反应监测分析[J].医学信息,2022,35(02):154-156.[doi:10.3969/j.issn.1006-1959.2022.02.039]
　XU Shan-shan,LIANG Jie,ZHENG Xiao-yan,et al.Analysis on the Surveillance of Adverse Events Following Immunizationin Yangzhou City from 2015 to 2019[J].Medical Information,2022,35(02):154-156.[doi:10.3969/j.issn.1006-1959.2022.02.039]
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2015-2019年扬州市疑似预防接种异常反应监测分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年02期
页码:
154-156
栏目:
调查分析
出版日期:
2022-01-15

文章信息/Info

Title:
Analysis on the Surveillance of Adverse Events Following Immunizationin Yangzhou City from 2015 to 2019
文章编号:
1006-1959（2022）02-0154-03
作者:
徐闪闪1; 2; 梁 杰2; 郑晓艳2; 吕大兵1
1.苏州大学公共卫生学院，江苏 苏州 215000；2.扬州市疾病预防控制中心，江苏 扬州 225001
Author(s):
XU Shan-shan1; 2; LIANG Jie2; ZHENG Xiao-yan2; LYU Da-bing1
1.Public Medical College of Soochow University,Suzhou 215000,Jiangsu,China;2.Yangzhou Center for Disease Control and Prevention,Yangzhou 225001,Jiangsu,China
关键词:
疫苗; 疑似预防接种异常反应; 传染病
Keywords:
Vaccine; Adverse event following immunization; Infectious disease
分类号:
R186
DOI:
10.3969/j.issn.1006-1959.2022.02.039
文献标志码:
A
摘要:
目的 分析2015-2019年扬州市疑似预防接种异常反应（AEFI）监测系统数据，了解全市AEFI发生概况和特征，评价AEFI监测系统的运行稳定性，为提高疫苗接种的安全性和服务质量提供科学依据。方法 通过中国免疫规划信息管理系统AEFI监测系统，收集扬州市2015年1月1日-2019年12月31日报告发生的个案信息，分析2015-2019年AEFI病例性别、年龄、时间分布，接种疫苗至发生AEFI的时间间隔分布，AEFI病例的分类、临床诊断分布及转归情况。结果 2015-2019年扬州市报告发生AEFI病例3707例，报告发生率64.35/10万剂，其中一般反应占88.78%，临床症状主要为发热/红肿/硬结；异常反应占10.73%，主要症状为过敏性皮疹，偶合症占0.49%；男性多于女性，＜1岁、第2季度和第3季度、接种1 d内发生率较高；97.74%的AEFI病例发生在预防接种后48 h内，99.87%的病例随访结果为好转/痊愈。结论 AEFI监测系统运行稳定，疫苗预防接种的安全性较高，可探索开展主动监测，进一步提高AEFI监测敏感性。
Abstract:
Objective To analyze the data of surveillance adverse events following immunization (AEFI) in Yangzhou City from 2015 to 2019, and to grasp the situation and feature of AEFI incidence in the city, so as to evaluate the stability of the monitoring system and provide scientific evidence to improving the safety and quality of vaccination.Methods The AEFI surveillance information system of China Immunization Program was used to derive the AEFI report case data occurred from January 1,2015 to December 31,2019 in Yangzhou City, all cases were analyzed in terms of gender, age, seasonal distribution, time interval between vaccination and reaction, case classification, clinical diagnosis and outcome.Results A total of 3707 AEFI cases were reported in Yangzhou from 2015 to 2019. The reported incidence was 64.35/100 000 doses, of which the general reaction accounted for 88.78%. The main clinical symptoms were fever/swelling/sclerosis. Abnormal reaction accounted for 10.73%, the main symptoms were allergic rash, coupling accounted for 0.49% ; males were more than females, with a higher incidence of <1 year old, in the second and third quarters, and within 1 day of inoculation; 97.74% of AEFI cases occurred within 48 hours after vaccination, and 99.87 % of cases were followed up for improvement/recovery.Conclusion The AEFI monitoring system is stable, and the safety of vaccination is high. Active monitoring can be explored to further improve the sensitivity of AEFI monitoring.

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