[1]张 慧,胡广越,殷 红.菌群干预与免疫治疗的研究进展[J].医学信息,2022,35(11):54-59.[doi:10.3969/j.issn.1006-1959.2022.11.016]
 ZHAHG Hui,HU Guang-yue,YIN Hong.Research Progress in Microbial Intervention and Immunotherapy[J].Medical Information,2022,35(11):54-59.[doi:10.3969/j.issn.1006-1959.2022.11.016]
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菌群干预与免疫治疗的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年11期
页码:
54-59
栏目:
综述
出版日期:
2022-06-01

文章信息/Info

Title:
Research Progress in Microbial Intervention and Immunotherapy
文章编号:
1006-1959(2022)11-0054-06
作者:
张 慧胡广越殷 红
(1.马鞍山市人民医院血液科,安徽 马鞍山 243000;2.苏州大学附属第一医院肿瘤科,江苏 苏州 215006)
Author(s):
ZHAHG HuiHU Guang-yueYIN Hong
(1.Department of Hematology,Ma’anshan People’s Hospital,Ma’anshan 243000,Anhui,China;2.Department of Oncology,the First Affiliated Hospital of Soochow University,Suzhou 215006,Jiangsu,China)
关键词:
肠道菌群菌群干预肿瘤免疫治疗
Keywords:
Intestinal floraMicrobial interventionTumorImmunotherapy
分类号:
R730.51
DOI:
10.3969/j.issn.1006-1959.2022.11.016
文献标志码:
A
摘要:
随着精准医疗的发展,免疫治疗在肿瘤的治疗发挥着越来越重要的作用,其中免疫检查点抑制剂最受关注,但存在应答率低、出现免疫相关不良反应事件致使治疗延缓甚至提前终止等问题。未来对各种癌症的治疗方向将针对免疫和代谢检查点以及微生物群。肠道菌群与宿主免疫密切相关,其对免疫的调节作用近年来受到广泛关注。最近的研究证实,肠道菌群可以改善免疫治疗疗效、缓解免疫不良反应。本文就肠道菌群与肿瘤、免疫的关系,肠道菌群干预疗法调节免疫治疗的现状及肠道菌群在免疫治疗上的未来方向3个方面进行综述。
Abstract:
With the progress and development of precision medicine, immunotherapy is playing an increasingly important role in the treatment of tumors. Among them, immune checkpoint inhibitors have attracted the most attention, but there are some problems, such as low response rate and the occurrence of immune-related adverse events that cause the delay or even early termination of treatment. In the future, treatments for various cancers will target immune and metabolic checkpoints as well as gut microbial communities. Intestinal flora is closely related to host immunity, and its regulation on immunity has attracted wide attention in recent years. Recent studies have confirmed that intestinal flora can improve the efficacy of immunotherapy and alleviate immune adverse reactions. This article reviews the relationship between intestinal flora and tumor and immunity, the current status of intestinal flora intervention therapy and the future direction of intestinal flora in immunotherapy.

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