[1]金力荣,杨麦青,徐洪波,等.TGF-β1、TNF-α、IL-4、IL-6在早期胚胎停育中的意义[J].医学信息,2022,35(11):93-96.[doi:10.3969/j.issn.1006-1959.2022.11.024]
　JIN Li-rong,YANG Mai-qing,XU Hong-bo,et al.Significance of TGF-β1, TNF-α, IL-4 and IL-6 in Early Embryo Arrest[J].Medical Information,2022,35(11):93-96.[doi:10.3969/j.issn.1006-1959.2022.11.024]
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TGF-β1、TNF-α、IL-4、IL-6在早期胚胎停育中的意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年11期
页码:
93-96
栏目:
论著
出版日期:
2022-06-01

文章信息/Info

Title:
Significance of TGF-β1, TNF-α, IL-4 and IL-6 in Early Embryo Arrest
文章编号:
1006-1959（2022）11-0093-04
作者:
金力荣; 杨麦青; 徐洪波; 等
（1.昌邑市人民医院产科，山东 昌邑 261300；2.昌邑市人民医院病理科，山东 昌邑 261300；3.潍坊市人民医院病理科，山东 潍坊 261041；4.昌邑市人民医院输血科，山东 昌邑 261300；5.潍坊护理职业学院健康管理系，山东 潍坊 261041）
Author(s):
JIN Li-rong; YANG Mai-qing; XU Hong-bo; et al.
(1.Department of Obstetrics,Changyi People’s Hospital,Changyi 261300,Shandong,China;2.Department of Pathology,Changyi People’s Hospital,Changyi 261300,Shandong,China;3.Department of Pathology,Weifang People’s Hospital,Weifang 261041,Shandong,China;4.De
关键词:
早期胚胎停育; TGF-β1; TNF-α; IL-4; IL-6
Keywords:
Early embryonic arrest; TGF-β1; TNF-α; IL-4; IL-6
分类号:
R714
DOI:
10.3969/j.issn.1006-1959.2022.11.024
文献标志码:
A
摘要:
目的 观察早期胚胎停育患者血清中转化生长因子β1（TGF-β1）、肿瘤坏死因子（TNF-α）、白细胞介素4（IL-4）和白细胞介素6（IL-6）的表达水平，探讨其在早期胚胎停育中的作用。方法 选取2018年1月-2021年8月在昌邑市人民医院确诊的早期胚胎停育患者35例作为观察组，并选取35例同期正常孕妇为对照组，比较两组TGF-β1、TNF-α、IL-4、IL-6的表达情况，分析TGF-β1、TNF-α、IL-4、IL-6与临床指标的关系及TGF-β1的表达与TNF-α、IL-4、IL-6的关系。结果 观察组血清TGF-β1、IL-4、IL-6的表达低于对照组，TNF-α的表达高于对照组（P＜0.05）；TGF-β1、TNF-α、IL-4、IL-6的表达与年龄、孕周、停经天数、孕囊大小均无关（P＞0.05）；TGF-β1的表达与IL-4（r=0.368）、IL-6（r=0.338）的表达呈正相关，与TNF-α的表达呈负相关（r=-0.329）。结论 早期胚胎停育患者血清中TGF-β1、IL-4、IL-6的表达较正常孕妇降低，TNF-α的表达升高；TGF-β1的表达分别与IL-4、IL-6的表达呈正相关，与TNF-α的表达呈负相关。
Abstract:
Objective To observe the expression of transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4) and interleukin-6 (IL-6) in serum of patients with early embryo arrest, and to explore its role in early embryo arrest.Methods A total of 35 patients with early embryo arrest diagnosed in Changyi People’s Hospital from January 2018 to August 2021 were selected as the observation group, and 35 normal pregnant women at the same period were selected as the control group. The expressions of TGF-β1, TNF-α, IL-4 and IL-6 were compared between the two groups. The relationship between TGF-β1, TNF-α, IL-4, IL-6 and clinical indicators and the relationship between TGF-β1 expression and TNF-α, IL-4, IL-6 were analyzed.Results The expression of serum TGF-β1, IL-4 and IL-6 in the observation group was lower than that in the control group, and the expression of TNF-α was higher than that in the control group (P<0.05). The expression of TGF-β1, TNF-α, IL-4 and IL-6 was not correlated with age, gestational age, amenorrhea days and gestational sac size (P>0.05). The expression of TGF-β1 was positively correlated with the expressions of IL-4 (r=0.368) and IL-6 (r=0.338), and negatively correlated with the expression of TNF-α (r=-0.329).Conclusion The expression of TGF-β1, IL-4 and IL-6 in serum of patients with early embryo abortion is lower than that of normal pregnant women, and the expression of TNF-α is higher. The expression of TGF-β1 is positively correlated with the expression of IL-4 and IL-6, respectively, and negatively correlated with the expression of TNF-α.

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更新日期/Last Update: 1900-01-01