[1]冯 登,程 鹏,王 毅,等.miRNA在动脉粥样硬化中调控血管平滑肌细胞的研究进展[J].医学信息,2023,36(06):176-179.[doi:10.3969/j.issn.1006-1959.2023.06.040]
 FENG Deng,CHENG Peng,WANG Yi,et al.Research Progress of miRNA Regulating Vascular Smooth Muscle Cells in Atherosclerosis[J].Journal of Medical Information,2023,36(06):176-179.[doi:10.3969/j.issn.1006-1959.2023.06.040]
点击复制

miRNA在动脉粥样硬化中调控血管平滑肌细胞的研究进展()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年06期
页码:
176-179
栏目:
综述
出版日期:
2023-03-15

文章信息/Info

Title:
Research Progress of miRNA Regulating Vascular Smooth Muscle Cells in Atherosclerosis
文章编号:
1006-1959(2023)06-0176-05
作者:
冯 登程 鹏王 毅
(1.川北医学院临床医学系,四川 南充 637000;2.川北医学院附属医院血管外科,四川 南充 637000)
Author(s):
FENG DengCHENG PengWANG Yiet al.
(1.Department of Clinical Medicine,North Sichuan Medical College,Nanchong 637000,Sichuan,China;2.Department of Vascular Surgery,the Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)
关键词:
动脉粥样硬化微小RNA血管平滑肌细胞
Keywords:
AtherosclerosismicroRNAVascular smooth muscle cells
分类号:
R543.5
DOI:
10.3969/j.issn.1006-1959.2023.06.040
文献标志码:
A
摘要:
血管平滑肌细胞(VSMCs)参与人类动脉粥样硬化进展的各个阶段。miRNA是非编码的小RNA,通过翻译抑制或信使RNA(mRNA)衰变在转录后水平调节基因表达。近年来研究发现,参与动脉粥样硬化的VSMCs多种功能都受到miRNA的调控。本文对miRNA进行概述,并对miRNA在VSMCs功能调节中的作用及其临床应用进行综述,以期为临床治疗提供参考。
Abstract:
Vascular smooth muscle cells (VSMCs) are involved in various stages of human atherosclerosis. MiRNAs are non-coding small RNAs that regulate gene expression at the post-transcriptional level through translation inhibition or messenger RNA ( mRNA ) decay. Recent studies have found that many functions of VSMCs involved in atherosclerosis are regulated by miRNAs. In this paper, miRNA is summarized, and the role of miRNA in the functional regulation of VSMCs and its clinical application are reviewed in order to provide reference for clinical treatment.

参考文献/References:

[1]Hajibabaie F,Kouhpayeh S,Mirian M,et al.MicroRNAs as the actors in the atherosclerosis scenario[J].J Physiol Biochem,2020,76(1):1-12.[2]Vartak T,Kumaresan S,Brennan E.Decoding microRNA drivers in atherosclerosis[J].Biosci Rep,2022,42(7):BSR20212355.[3]Yurikova OY,Aisina DE,Niyazova RE,et al.The interaction of miRNA-5p and miRNA-3p with the mRNAs of orthologous genes[J].Mol Biol (Mosk),2019,53(4):692-704.[4]Chandrasekera D,Katare R.Exosomal microRNAs in diabetic heart disease[J].Cardiovasc Diabetol,2022,21(1):122.[5]Saliminejad K,Khorram Khorshid HR,et al.An overview of microRNAs: biology,functions,therapeutics,and analysis methods[J].J Cell Physiol,2019,234(5):5451-5465.[6]Li ML,Liu Q,Lei JY,et al.MiR-362-3p inhibits the proliferation and migration of vascular smooth muscle cells in atherosclerosis by targeting ADAMTS1[J].Biochem Biophys Res Commun,2017,493(1):270-276.[7]Yang N,Dong B,Song YQ,et al.Downregulation of miR-637 promotes vascular smooth muscle cell proliferation and migration via regulation of insulin-like growth factor-2[J].Cell Mol Biol Lett,2020,25:30.[8]Wang HJ,Wei Z,Li HL,et al.MiR-377-3p inhibits atherosclerosis-associated vascular smooth muscle cell proliferation and migration via targeting neuropilin2[J].Biosci Rep,2020,40(6):BSR20193425.[9]Ghasempour G,Mahabadi VP,Shabani M,et al.MiR-181b and miR-204 suppress the VSMC proliferation and migration by downregulation of HCK[J].Microvasc Res,2021,136:104172.[10]Ye D,Lou GH,Li AC,et al.MicroRNA-125a-mediated regulation of the mevalonate signaling pathway contributes to high glucose?induced proliferation and migration of vascular smooth muscle cells[J].Mol Med Rep,2020,22(1):165-174.[11]Feng SD,Gao L,Zhang DH,et al.MiR-93 regulates vascular smooth muscle cell proliferation,and neointimal formation through targeting Mfn2[J].Int J Biol Sci,2019,15(12):2615-2626.[12]Liu SY,Yang YY,Jiang SY,et al.MiR-378a-5p regulates proliferation and migration in vascular smooth muscle cell by targeting CDK1[J].Front Genet,2019,10:22.[13]Wang JY,Zhang CX,Li C,et al.MicroRNA-92a promotes vascular smooth muscle cell proliferation and migration through the ROCK/MLCK signalling pathway[J].J Cell Mol Med,2019,23(5):3696-3710.[14]Zhang C,Wang X.MiR-320a targeting RGS5 aggravates atherosclerosis by promoting migration and proliferation of ox-LDL-stimulated vascular smooth muscle cells[J].J Cardiovasc Pharmacol,2022,80(1):110-117.[15]Kang XL,Cao SM,Ji Z,et al.MiR-3646 promotes vascular inflammation and augments vascular smooth muscle cell proliferation and migration in progression of coronary artery disease by directly targeting RHOH[J].Int J Clin Exp Pathol,2018,11(12):5830-5839.[16]Sun B,Cao QT,Meng M,et al.MicroRNA-186-5p serves as a diagnostic biomarker in atherosclerosis and regulates vascular smooth muscle cell proliferation and migration[J].Cell Mol Biol Lett,2020,25:27.[17]Phadwal K,Feng D,Zhu DX,et al.Autophagy as a novel therapeutic target in vascular calcification[J].Pharmacol Ther,2020,206:107430.[18]Farina FM,Hall IF,Serio S,et al.MiR-128-3p is a novel regulator of vascular smooth muscle cell phenotypic switch and vascular diseases[J].Circ Res,2020,126(12):e120-e135.[19]Yan SR,Chen J,Zhang T,et al.Micro-RNA-338-3p promotes the development of atherosclerosis by targeting desmin and promoting proliferation[J].Mol Biotechnol,2021,63(9):840-848.[20]Yu TC,Wang T,Kuang SF,et al.A microRNA-17-5p/homeobox B13 axis participates in the phenotypic modulation of vascular smooth muscle cells[J].Mol Med Rep,2021,24(4):731.[21]常峥峥,林飞,赵晖,等.微小RNA-33a对平滑肌细胞表型转化的调控机制研究[J].中国循环杂志,2021,36(12):1221-1228.[22]Zhuang XJ,Gao F,Shi L,et al.MicroRNA-146b-3p regulates the dysfunction of vascular smooth muscle cells via repressing phosphoinositide-3 kinase catalytic subunit gamma[J].Bioengineered,2021,12(1):2627-2638.[23]Chin DD,Poon C,Wang J,et al.MiR-145 micelles mitigate atherosclerosis by modulating vascular smooth muscle cell phenotype[J].Biomaterials,2021,273:120810.[24]Wang XQ,Li H,Zhang YT,et al.Suppression of miR-4463 promotes phenotypic switching in VSMCs treated with Ox-LDL[J].Cell Tissue Res,2021,383(3):1155-1165.[25]Hu M,Jia F,Huang WP,et al.Substrate stiffness differentially impacts autophagy of endothelial cells and smooth muscle cells[J].Bioact Mater,2021,6(5):1413-1422.[26]Cui RR,Ye SL,Zhong JY,et al.MicroRNA-494 inhibits apoptosis of murine vascular smooth muscle cells in vitro[J].Mol Med Rep,2019,19(5):4457-4467.[27]Luo Y,Li YM,Peng H,et al.MiR-140-5p regulates vascular smooth muscle cell viability,migration and apoptosis by targeting ROBO4 gene expression in atherosclerosis[J].Mol Med Rep,2021,23(3):213.[28]Wang L,Zhou JL,Guo F,et al.MicroRNA-665 regulates cell proliferation and apoptosis of vascular smooth muscle cells by targeting TGFBR1[J].Int Heart J,2021,62(2):371-380.[29]Bao Q,Jia H,A R,et al.MiR-210 inhibits hypoxia-induced apoptosis of smooth muscle cells via targeting MEF2C[J].Int J Clin Exp Pathol,2019,12(5):1846-1858.[30]Wang L,Wang ZB,Zhang R,et al.MiR-4787-5p regulates vascular smooth muscle cell apoptosis by targeting PKD1 and inhibiting the PI3K/Akt/FKHR pathway[J].J Cardiovasc Pharmacol,2021,78(2):288-296.[31]Wang WR,Chen LF,Shang CX,et al.MiR-145 inhibits the proliferation and migration of vascular smooth muscle cells by regulating autophagy[J].J Cell Mol Med,2020,24(12):6658-6669.[32]Qin Y,Zheng B,Yang GS,et al.Salvia miltiorrhiza-derived sal-miR-58 induces autophagy and attenuates inflammation in vascular smooth muscle cells[J].Mol Ther Nucleic Acids,2020,21:492-511.[33]Liang X,Hu MY,Yuan W,et al.MicroRNA-4487 regulates vascular smooth muscle cell proliferation,migration and apoptosis by targeting RAS p21 protein activator 1[J].Pathol Res Pract,2022,234:153903.[34]Grootaert MOJ,Moulis M,Roth L,et al.Vascular smooth muscle cell death,autophagy and senescence in atherosclerosis[J].Cardiovasc Res,2018,114(4):622-634.[35]Chen YL,Sheu JJ,Sun CK,et al.MicroRNA-214 modulates the senescence of vascular smooth muscle cells in carotid artery stenosis[J].Mol Med,2020,26(1):46.[36]Chen TB,Liang QY,Xu JL,et al.MiR-665 regulates vascular smooth muscle cell senescence by interacting with LncRNA GAS5/SDC1[J].Front Cell Dev Biol,2021,9:700006.[37]Tan P,Wang HQ,Zhan JK,et al.Rapamycin-induced miR-30a downregulation inhibits senescence of VSMCs by targeting Beclin1[J].Int J Mol Med,2019,43(3):1311-1320.[38]Durham AL,Speer MY,Scatena M,et al.Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness[J].Cardiovasc Res,2018,114(4):590-600.[39]He L,Xu JS,Bai YL,et al.MicroRNA-103a regulates the calcification of vascular smooth muscle cells by targeting runt-related transcription factor 2 in high phosphorus conditions[J].Exp Ther Med,2021,22(3):1036.[40]Han YC,Zhang JC,Huang S,et al.MicroRNA-223-3p inhibits vascular calcification and the osteogenic switch of vascular smooth muscle cells[J].J Biol Chem,2021,296:100483.[41]Cao JS,Chen L,Zhong XL,et al.miR32-5p promoted vascular smooth muscle cell calcification by upregulating TNFα in the microenvironment[J].BMC Immunol,2020,21(1):3.[42]Li Y,Sun W,Saaoud F,et al.MiR155 modulates vascular calcification by regulating Akt-FOXO3a signalling and apoptosis in vascular smooth muscle cells[J].J Cell Mol Med,2021,25(1):535-548.[43]Choe N,Shin S,Joung H,et al.The microRNA miR-134-5p induces calcium deposition by inhibiting histone deacetylase 5 in vascular smooth muscle cells[J].J Cell Mol Med,2020,24(18):10542-10550.[44]Zhang F,Li JX,Gu CX,et al.MiR-140-5p upregulation suppressed β-glycerophosphate-induced vascular smooth muscle cell calcification via targeting TLR4[J].Immunopharmacol Immunotoxicol,2022,44(3):295-305.[45]Wang J,Qian HL,Chen SY,et al.MiR-22 eluting cardiovascular stent based on a self-healable spongy coating inhibits in-stent restenosis[J].Bioact Mater,2021,6(12):4686-4696.[46]Izuhara M,Kuwabara Y,Saito N,et al.Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model[J].PLoS One,2017,12(3):e0172798.

相似文献/References:

[1]王立民,刘有旺,王恩波,等.以大黄素为声敏剂介导声动力疗法对小鼠 动脉粥样硬化治疗作用的研究[J].医学信息,2018,31(06):58.[doi:10.3969/j.issn.1006-1959.2018.06.019]
 WANG Li-min,LIU You-wang,WANG En-bo,et al.Study on the Effect of Emodin on the Treatment of Atherosclerosis in Mice[J].Journal of Medical Information,2018,31(06):58.[doi:10.3969/j.issn.1006-1959.2018.06.019]
[2]汤海霞,班 涛.大黄素与心血管疾病的研究[J].医学信息,2022,35(11):19.[doi:10.3969/j.issn.1006-1959.2022.11.006]
 TANG Hai-xia,BAN Tao.Research on Emodin and Cardiovascular Diseases[J].Journal of Medical Information,2022,35(06):19.[doi:10.3969/j.issn.1006-1959.2022.11.006]
[3]陈玉媛,易爱姣,谭齐鸣,等.中青年冠状动脉粥样硬化患者颈动脉硬化的超声特征[J].医学信息,2019,32(02):175.[doi:10.3969/j.issn.1006-1959.2019.02.054]
 CHEN Yu-yuan,YI Ai-jiao,TAN Qi-ming,et al.Ultrasound Characteristics of Carotid Atherosclerosis in Young and Middle-aged Patients with Coronary Atherosclerosis[J].Journal of Medical Information,2019,32(06):175.[doi:10.3969/j.issn.1006-1959.2019.02.054]
[4]杨玉媛,刘有旺,李 腾,等.Th17细胞对动脉粥样硬化斑块易损性和斑块破裂的影响研究[J].医学信息,2018,31(18):53.[doi:10.3969/j.issn.1006-1959.2018.18.017]
 YANG Yu-yuan,LIU You-wang,LI Teng,et al.Effect of Th17 Cells on Atherosclerotic Plaque Vulnerability and Plaque Rupture[J].Journal of Medical Information,2018,31(06):53.[doi:10.3969/j.issn.1006-1959.2018.18.017]
[5]薛 一,孔莫维,高 宇.脂蛋白相关磷脂酶A2与冠心病的研究[J].医学信息,2019,32(12):53.[doi:10.3969/j.issn.1006-1959.2019.12.017]
 XUE Yi,KONG Mo-wei,GAO Yu.Research on Lipoprotein-associated Phospholipase A2 and Coronary Heart Disease[J].Journal of Medical Information,2019,32(06):53.[doi:10.3969/j.issn.1006-1959.2019.12.017]
[6]李 靖.非高密度脂蛋白胆固醇与心脑血管疾病的关系研究[J].医学信息,2022,35(12):100.[doi:10.3969/j.issn.1006-1959.2022.12.024]
 LI Jing.Study on the Relationship Between Non-high Density Lipoprotein Cholesterol and Cardiovascular and Cerebrovascular Diseases[J].Journal of Medical Information,2022,35(06):100.[doi:10.3969/j.issn.1006-1959.2022.12.024]
[7]郝冬冬,高 宇.C肽与动脉粥样硬化的相关性研究[J].医学信息,2019,32(09):28.[doi:10.3969/j.issn.1006-1959.2019.09.010]
 HAO Dong-dong,GAO Yu.Correlation between C-peptide and Atherosclerosis[J].Journal of Medical Information,2019,32(06):28.[doi:10.3969/j.issn.1006-1959.2019.09.010]
[8]严文文,陈 然,金 平,等.老年患者颅内动脉粥样硬化性狭窄的分布和危险因素研究[J].医学信息,2019,32(09):78.[doi:10.3969/j.issn.1006-1959.2019.09.025]
 YAN Wen-wen,CHEN Ran,JIN Ping,et al.Distribution and Risk Factors of Intracranial Atherosclerotic Stenosis in Elderly Patients[J].Journal of Medical Information,2019,32(06):78.[doi:10.3969/j.issn.1006-1959.2019.09.025]
[9]李慧丹,赵文鸽,王学惠.Nox4在同型半胱氨酸介导的动脉粥样硬化中作用的研究[J].医学信息,2019,32(15):45.[doi:10.3969/j.issn.1006-1959.2019.15.015]
 LI Hui-dan,ZHAO Wen-ge,WANG Xue-hui.Research on the Role of Nox4 in Homocysteine-mediated Atherosclerosis[J].Journal of Medical Information,2019,32(06):45.[doi:10.3969/j.issn.1006-1959.2019.15.015]
[10]罗婵娟.子宫内膜癌组织中miR-143的表达及与预后的相关性分析[J].医学信息,2022,35(15):75.[doi:10.3969/j.issn.1006-1959.2022.15.016]
 LUO Chan-juan.Expression of miR-143 in Endometrial Carcinoma Tissues and its Correlation with Prognosis[J].Journal of Medical Information,2022,35(06):75.[doi:10.3969/j.issn.1006-1959.2022.15.016]

更新日期/Last Update: 1900-01-01