[1]陈 超,陈冯梅.血清尿酸/肌酐比值与老年人非酒精性脂肪肝的相关性研究[J].医学信息,2023,36(19):71-74.[doi:10.3969/j.issn.1006-1959.2023.19.014]
　CHEN Chao,CHEN Feng-mei.Correlation Between Serum Uric Acid/Creatinine Ratio and Nonalcoholic Fatty Liver Disease in the Elderly[J].Journal of Medical Information,2023,36(19):71-74.[doi:10.3969/j.issn.1006-1959.2023.19.014]
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血清尿酸/肌酐比值与老年人非酒精性脂肪肝的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年19期
页码:
71-74
栏目:
论著
出版日期:
2023-10-01

文章信息/Info

Title:
Correlation Between Serum Uric Acid/Creatinine Ratio and Nonalcoholic Fatty Liver Disease in the Elderly
文章编号:
1006-1959（2023）19-0071-04
作者:
陈 超; 陈冯梅
（1.宝应县妇幼保健医院内科，江苏 宝应 225800；2.苏州卫生职业技术学院预防医学教研室，江苏 苏州 215000）
Author(s):
CHEN Chao; CHEN Feng-mei
(1.Baoying Maternal and Child Health Hospital, Internal Medicine,Baoying 225800,Jiangsu,China;2.Department of Preventive Medicine,Suzhou Vocational Health College,Suzhou 215000,Jiangsu,China)
关键词:
老年人; 非酒精性脂肪肝; 尿酸/肌酐比值
Keywords:
Elderly; Nonalcoholic fatty liver; Uric acid/creatinine ratio
分类号:
R575.5
DOI:
10.3969/j.issn.1006-1959.2023.19.014
文献标志码:
A
摘要:
目的 探讨70岁以上老年人群中血清尿酸/肌酐比值与老年人非酒精性脂肪肝的相关性。方法 选择2016年1月-2019年7月连续在苏州市立医院门诊查体的年龄≥70岁人群共2552名（男1079名，女1473名），测定身高、体重、血压、尿酸、肌酐血脂、血糖等指标，对比分析NAFLD组、非NAFLD组人群的血清尿酸/肌酐比值。结果 按NAFLD是否患病分组后的一般资料比较，除LDL、Cr外，两组其他各变量比较，差异有统计学意义（P＜0.05）；NAFLD组的吸烟概率、饮酒概率、SUA、Cr、SUA/Cr水平均高于非NAFLD组（P＜0.05）；SUA/Cr水平诊断NAFLD的ROC曲线下面积为0.651，SUA/Cr预测患者NAFLD发病风险的最佳临界值为4.26。以SUA/Cr为自变量，以NAFLD是否患病为因变量，在调整多因素变量后，SUA/Cr≥4.26的人群发生NAFLD的OR是2.786，95%CI是1.976~3.922（P＜0.05）。结论 SUA/Cr水平和70岁以上的老年人NAFLD发病风险存在正相关，SUA/Cr对于临床上鉴别NAFLD高危人群具有重要意义。
Abstract:
Objective To investigate the correlation between serum uric acid/creatinine ratio and nonalcoholic fatty liver in the elderly over 70 years old.Methods A total of 2552 people (1079 males and 1473 females) aged ≥70 years old who had continuous physical examination in Suzhou Municipal Hospital from January 2016 to July 2019 were selected. The height, weight, blood pressure, uric acid, creatinine, blood lipid, blood glucose and other indicators were measured. The serum uric acid/creatinine ratio of NAFLD group and non-NAFLD group was compared and analyzed.Results Comparison of general data after grouping according to the prevalence of NAFLD, except LDL and Cr, there were statistically significant differences in other variables between the two groups (P＜0.05). The smoking probability, drinking probability and the levels of SUA, Cr and SUA/Cr in the NAFLD group were higher than those in the non-NAFLD group(P＜0.05). The area under the ROC curve of SUA/Cr level in the diagnosis of NAFLD was 0.651, and the optimal cut-off value of SUA/Cr in predicting the risk of NAFLD was 4.26. With SUA/Cr as the independent variable and NAFLD as the dependent variable, after adjusting for multivariate variables, the OR of NAFLD in people with SUA/Cr≥4.26 was 2.786, and the 95%CI was 1.976-3.922 (P＜0.05).Conclusion There is a positive correlation between the level of SUA/Cr and the risk of NAFLD in people over 70 years old. SUA/Cr plays an important role in the clinical identification of high risk groups of NAFLD.

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更新日期/Last Update: 1900-01-01