[1]刘 雅,李 黎,吴玉华.NLRP3及相关细胞因子在HIV／TB双重感染者血清中表达水平的研究[J].医学信息,2024,37(03):118-120.[doi:10.3969/j.issn.1006-1959.2024.03.023]
　LIU Ya,LI Li,WU Yu-hua.The Expression Levels of Serum NLRP3 and Related Cytokines in HIV/TB Co-infected Patients[J].Journal of Medical Information,2024,37(03):118-120.[doi:10.3969/j.issn.1006-1959.2024.03.023]
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NLRP3及相关细胞因子在HIV／TB双重感染者血清中表达水平的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年03期
页码:
118-120
栏目:
论著
出版日期:
2024-02-01

文章信息/Info

Title:
The Expression Levels of Serum NLRP3 and Related Cytokines in HIV/TB Co-infected Patients
文章编号:
1006-1959（2024）03-0118-03
作者:
刘 雅; 李 黎; 吴玉华
（1.石河子大学医学院，新疆 石河子 832000；2.喀什地区第一人民医院呼吸内科，新疆 喀什 844000；3.省部共建中亚高发病成因与防治国家重点实验室，新疆 喀什 844000）
Author(s):
LIU Ya; LI Li; WU Yu-hua
(1.Shihezi University School of Medicine,Shihezi 832000,Xinjiang,China;2.Department of Respiratory Medicine,the First People’s Hospital of Kashi Prefecture,Kashi 844000,Xinjiang,China;3.State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Kashi 844000,Xinjiang,China)
关键词:
结核分枝杆菌; HIV/TB双重感染; 白细胞介素; NLRP3
Keywords:
Mycobacterium tuberculosis; HIV/TB co-infection; Interleukin; NLRP3
分类号:
R512.91；R521
DOI:
10.3969/j.issn.1006-1959.2024.03.023
文献标志码:
A
摘要:
目的 研究HIV/TB双重感染者血清中NLRP3炎症小体及相关细胞因子的表达水平。方法 收集2021年1月-12月喀什地区第一人民医院收治的HIV、TB、HIV/TB患者为研究对象，分别设为HIV组、TB组、HIV/TB组，每组20例，使用酶联免疫吸附法检测患者血清IL-6、IL-17、IL-22、IL-23、TNF-α的表达水平，使用实时荧光定量PCR检测患者血清中NLRP3mRNA的表达水平。比较各组实验室指标。结果 HIV/TB组IL-6、IL-17、IL-22、NLRP3mRNA水平高于TB组，IL-23水平低于TB组，差异有统计学意义（P＜0.05）；HIV/TB组IL-6、IL-17、IL-22、IL-23、TNF-α及NLRP3mRNA水平高于HIV组，差异有统计学意义（P＜0.05）。结论 HIV/TB双重感染患者较单纯HIV患者、TB感染者体内体内细胞因子失衡更加明显，可能与疾病的发生发展密切相关。
Abstract:
Objective To investigate the expression levels of NLRP3 and related cytokines in the serum of HIV/TB co-infected patients.Methods HIV, TB and HIV/TB patients admitted to the First People’s Hospital of Kashgar Prefecture from January to December 2021 were collected as the research objects, which were set as HIV group, TB group and HIV/TB group, with 20 patients in each group. The expression levels of IL-6, IL-17, IL-22, IL-23 and TNF-α in serum of patients were detected by enzyme-linked immunosorbent assay, and the expression levels of NLRP3mRNA in serum of patients were detected by real-time fluorescence quantitative PCR. The laboratory indexes of each group were compared.Results The levels of IL-6, IL-17, IL-22 and NLRP3mRNA in HIV/TB group were higher than those in TB group, and the level of IL-23 was lower than that in TB group, the difference was statistically significant (P<0.05). The levels of IL-6, IL-17, IL-22, IL-23, TNF-α and NLRP3 mRNA in HIV/TB group were higher than those in HIV group, , the difference was statistically significant (P<0.05).Conclusion The imbalance of cytokines in patients with HIV/TB co-infection is more obvious than that in HIV patients and TB patients, which may be closely related to the occurrence and development of the disease.

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更新日期/Last Update: 1900-01-01