[1]王春城.三维适形放疗在脑胶质瘤治疗中的应用及对生存期的影响[J].医学信息,2019,32(05):173-174.[doi:10.3969/j.issn.1006-1959.2019.05.057]
　WANG Chun-cheng.Application of Three-dimensional Conformal Radiotherapy in the Treatment of Glioma and its Effect on Survival[J].Medical Information,2019,32(05):173-174.[doi:10.3969/j.issn.1006-1959.2019.05.057]
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三维适形放疗在脑胶质瘤治疗中的应用及对生存期的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年05期
页码:
173-174
栏目:
诊疗技术
出版日期:
2019-03-01

文章信息/Info

Title:
Application of Three-dimensional Conformal Radiotherapy in the Treatment of Glioma and its Effect on Survival
文章编号:
1006-1959（2019）05-0173-02
作者:
王春城
（佳木斯市中心医院神经外科，黑龙江 佳木斯 154000）
Author(s):
WANG Chun-cheng
(Department of Neurosurgery,Jiamusi Central Hospital,Jiamusi 154000,Heilongjiang,China)
关键词:
三维适形放疗; 脑胶质瘤; 辐射剂量; 生存率
Keywords:
Three-dimensional conformal radiotherapy; Glioma; Radiation dose; Survival rate
分类号:
R739.41
DOI:
10.3969/j.issn.1006-1959.2019.05.057
文献标志码:
A
摘要:
目的 探讨三维适形放疗在脑胶质瘤患者中的临床效果及对生存期的影响。方法 选择2013年6月~2015年10月治疗的脑胶质瘤患者62例作为研究对象，采用随机数字表分为对照组和观察组，各31例。对照组采用常规方法放疗，观察组采用三维适形放疗，两组均进行3个月治疗，治疗完毕后对患者进行3年随访，比较两组照射剂量及对生存期的影响。结果 两组均顺利完成治疗，观察组治疗过程中Dmean照射剂量（63.29±5.77）Gy、CI照射剂量（0.84±0.12）Gy，高于对照组的（53.45±4.51）Gy、（0.57±0.10）Gy（t=10.295、6.847，P均=0.000）；观察组治疗后2年、3年生存率分别为93.55%和83.87%，均高于对照组74.19%和64.52%（?字2=6.893、5.773，P=0.013、0.046）。结论 将三维适形放疗用于脑胶质瘤患者中能降低辐射剂量，提高患者生存率，可借鉴应用。
Abstract:
Objective To investigate the clinical effects of three-dimensional conformal radiotherapy in patients with glioma and its impact on survival. Methods A total of 62 patients with glioma treated from June 2013 to October 2015 were enrolled. The randomized digital table was divided into control group and observation group, 31 cases each. The control group received conventional radiotherapy, and the observation group received three-dimensional conformal radiotherapy. The two groups were treated for 3 months. After the treatment, the patients were followed for 3 years. The effects of the two groups on the dose and survival were compared.Results The treatment was successfully completed in both groups. In the observation group, Dmean (63.29±5.77) Gy, CI irradiation dose (0.84±0.12) Gy was higher than that of the control group (53.45±4.51) Gy, (0.57±0.10) Gy ( t=10.295, 6.847, P=0.000); the 2-year and 3-year survival rates of the observation group were 93.55% and 83.87%, respectively, which were higher than 74.19% and 64.52% of the control group(?字2=6.893,5.773;P= 0.013,0.046).Conclusion Three-dimensional conformal radiotherapy can reduce the radiation dose and improve the survival rate of patients with glioma, which can be used for reference.

参考文献/References:


[1]孔德胤.三维适形放疗联合替莫唑胺在脑胶质瘤患者中的疗效观察及对生存期的影响研究[J].临床医药文献电子杂志,2018,5(69):107.
[2]陈明锐,薛兴森,吴万福.恶性脑胶质瘤术后两种同步放化疗方案应用的临床疗效对比[J].实用癌症杂志,2018,33(7):1202-1204,1211.
[3]王伟,刘娟.三维适形放疗联合替莫唑胺化疗对恶性脑胶质瘤患者术后不良反应发生率及生存质量的影响[J].中国地方病防治杂志,2017,32(10):1183,1185.
[4]肖熹.三维适形放疗联合替莫唑胺在脑胶质瘤临床治疗中的安全性评价[J].三峡大学学报(自然科学版),2017,39(S1):145-146.
[5]李建明.三维适形放疗联合替莫唑胺化疗对恶性脑胶质瘤术后残留的疗效分析[J].中国临床神经外科杂志,2017,22(5):316-317,321.
[6]刘飞皎.三维适形放疗联合替莫唑胺治疗恶性脑胶质瘤术后患者的疗效分析[J].中国民康医学,2017,29(10):32-34.
[7]周绍兵,刘阳晨,尹小祥,等.恶性脑胶质瘤术后三维适形放疗联合三苯氧胺治疗的临床观察[J].现代肿瘤医学,2015,23(24):3582-3585.
[8]李德凡,蒋淑年,杨帆,等.高分级脑胶质瘤术后三维适形放疗联合替莫唑胺化疗的疗效[J].中国实用神经疾病杂志,2015, 18(2):52-53.

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更新日期/Last Update: 2019-03-01