[1]凌春艳.布地奈德气雾剂联合孟鲁司特钠治疗老年咳嗽变异性哮喘的疗效[J].医学信息,2020,33(07):144-145,148.[doi:10.3969/j.issn.1006-1959.2020.07.046]
　LING Chun-yan.Efficacy of Budesonide Aerosol Combined with Montelukast Sodium in the Treatment of Elderly Cough Variant Asthma[J].Medical Information,2020,33(07):144-145,148.[doi:10.3969/j.issn.1006-1959.2020.07.046]
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布地奈德气雾剂联合孟鲁司特钠治疗老年咳嗽变异性哮喘的疗效()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年07期
页码:
144-145,148
栏目:
药物与临床
出版日期:
2020-04-01

文章信息/Info

Title:
Efficacy of Budesonide Aerosol Combined with Montelukast Sodium in the Treatment of Elderly Cough Variant Asthma
文章编号:
1006-1959（2020）07-0144-03
作者:
凌春艳
（寻乌县人民医院药剂科，江西 寻乌 342200）
Author(s):
LING Chun-yan
(Department of Pharmacy,Xunwu County People’s Hospital,Xunwu 342200,Jiangxi,China)
关键词:
布地奈德; 孟鲁司特钠; 老年咳嗽变异性哮喘; 肺功能
Keywords:
Budesonide; Montelukast sodium; Cough variant asthma in the elderly; Lung function
分类号:
R725.6
DOI:
10.3969/j.issn.1006-1959.2020.07.046
文献标志码:
A
摘要:
目的 探讨布地奈德气雾剂联合孟鲁司特钠在老年咳嗽变异性哮喘患者治疗中的应用效果。方法 选取2017年9月~2019年5月我院老年咳嗽变异性哮喘患者60例作为研究对象，采用随机数字表法分为对照组与研究组，各30例。对照组在常规治疗的基础上给予布地奈德气雾剂治疗，观察组在对照组基础上给予孟鲁司特钠治疗。比较两组治疗前后肺功能指标[第1秒用力呼气量（FEV1）、用力肺活量（FVC）、呼气峰流速（PEF）]、咳嗽症状评分、治疗前后血清超敏C反应蛋白（hs-CRP）、降钙素原（PCT）、免疫球蛋白E（IgE）水平及不良反应发生情况。结果 治疗后两组肺功能指标、血清hs-CRP、PCT及IgE水平均较治疗前改善，研究组FVC、FEV1及PEF水平高于对照组，血清hs-CRP、PCT、IgE水平低于对照组（P＜0.05）；治疗后研究组日间咳嗽症状评分、夜间咳嗽症状评分均低于对照组（P＜0.05）；两组治疗期间均未发生严重不良反应。结论 布地奈德气雾剂联合孟鲁司特钠有助于改善老年咳嗽变异性哮喘患者肺功能，改善患者临床症状，降低炎症反应，减轻患者免疫反应，临床安全性较高。
Abstract:
Objective To explore the effect of budesonide aerosol combined with montelukast sodium in the treatment of elderly patients with cough variant asthma.Methods A total of 60 elderly patients with cough variant asthma in our hospital from September 2017 to May 2019 were selected as the research object, and they were divided into a control group and a research group by random number table method, 30 cases each. The control group was given budesonide aerosol on the basis of conventional treatment, and the observation group was given montelukast sodium on the basis of the control group. Pulmonary function indexes before and after treatment [forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), peak expiratory flow rate (PEF)], cough symptom score, and serum hypersensitive C-reactive protein (hs- CRP), procalcitonin (PCT), immunoglobulin E (IgE) levels and adverse reactions.Results After treatment, the lung function indexes, serum hs-CRP, PCT and IgE levels were improved compared with before treatment. The levels of FVC, FEV1 and PEF in the study group were higher than those in the control group, and the levels of serum hs-CRP, PCT and IgE were lower than those in the control group(P<0.05); the day and cough symptom scores of the study group after treatment were lower than those of the control group(P<0.05);No serious adverse reactions occurred during treatment in both groups.Conclusion Budesonide aerosol combined with montelukast sodium can improve lung function, improve clinical symptoms, reduce inflammatory response and alleviate immune response in elderly patients with cough variant asthma, and have higher clinical safety.

参考文献/References:

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更新日期/Last Update: 2020-04-01