[1]史爱红,刘爱玲,封 玲,等.凝血功能指标对不同类型子痫前期的诊断价值[J].医学信息,2020,33(21):90-93.[doi:10.3969/j.issn.1006-1959.2020.21.026]
　SHI Ai-hong,LIU Ai-ling,FENG Ling,et al.The Diagnostic Value of Coagulation Function Indexes for Different Types of Preeclampsia[J].Medical Information,2020,33(21):90-93.[doi:10.3969/j.issn.1006-1959.2020.21.026]
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凝血功能指标对不同类型子痫前期的诊断价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年21期
页码:
90-93
栏目:
论著
出版日期:
2020-11-01

文章信息/Info

Title:
The Diagnostic Value of Coagulation Function Indexes for Different Types of Preeclampsia
文章编号:
1006-1959（2020）21-0090-04
作者:
史爱红; 刘爱玲; 封 玲; 等
（徐州医科大学附属沭阳医院妇产科，江苏 沭阳 223600）
Author(s):
SHI Ai-hong; LIU Ai-ling; FENG Ling; et al
(Department of Obstetrics and Gynecology,Shuyang Hospital,Xuzhou Medical University,Shuyang 223600,Jiangsu,China)
关键词:
子痫前期; 凝血功能; 高血压; 孕妇
Keywords:
Preeclampsia; Coagulation function; Hypertension; Pregnant women
分类号:
R714.24+4；R446.1
DOI:
10.3969/j.issn.1006-1959.2020.21.026
文献标志码:
A
摘要:
目的 分析凝血功能指标对不同类型子痫前期（PE）的诊断价值。方法 选取2018年1月~2020年6月我院收治的65例PE孕妇为研究对象，根据病情严重程度分为轻度PE组（31例）和重度PE组（34例）；根据发病时间将发病孕周＜34周的29例设为早发型PE组，发病孕周≥34周的36例设为晚发型PE组。另选取同期于我院产检的健康孕妇35例为对照组。比较各组孕妇的一般资料及凝血功能指标（PT、APTT、INR、FIB）。应用ROC曲线分析凝血功能指标对轻度PE、重度PE、早发型PE和晚发型PE的诊断价值。结果 各组PE孕妇的PT、APTT较对照组均缩短，INR降低，FIB水平升高；重度PE组孕妇的PT、APTT较轻度PE组孕妇均缩短，INR降低，FIB水平升高；早发型PE组PT、APTT较晚发型PE组孕妇均缩短，INR均降低，FIB水平均升高，差异有统计学意义（P＜0.05）；ROC分析结果显示，FIB单独检测与四项指标联合检测诊断轻度PE的AUC分别为0.706、0.715（P＜0.05）；PT、APTT、FIB单独检测与四项指标联合检测诊断重度PE的AUC分别为0.714、0.672、0.841、0.905（P＜0.05）；PT、APTT、FIB单独检测与四项指标联合检测诊断早发型PE的AUC分别为0.701、0.669、0.822、0.885（P＜0.05）；FIB单独检测与四项指标联合检测诊断晚发型PE的AUC分别为0.735、0.768（P＜0.05）。结论 PT、APTT、INR、FIB四项凝血指标联合检测对轻度PE、重度PE、早发型PE和晚发型PE的发生具有一定的诊断价值，对重度PE、早发型PE的诊断价值更高。
Abstract:
Objective To analyze the diagnostic value of coagulation function indexes for different types of preeclampsia (PE).Methods 65 pregnant women with PE who were admitted to our hospital from January 2018 to June 2020 were selected as the research objects. According to the severity of the disease, they were divided into mild PE group (31 cases) and severe PE group (34 cases); 29 cases with onset gestational age ＜34 weeks were set as early-onset PE group, and 36 cases with onset gestational age ≥34 weeks set as late-onset PE group. In addition, 35 healthy pregnant women who underwent an obstetric examination in our hospital during the same period were selected as the control group. Compare the general data and coagulation function indexes (PT, APTT, INR, FIB) of pregnant women in each group. The ROC curve was used to analyze the diagnostic value of coagulation function indexes for mild PE, severe PE, early-onset PE and late-onset PE.Results Compared with the control group, the PT and APTT of pregnant women with PE in each group were shortened, the INR decreased, and the FIB level increased; the PT and APTT of the pregnant women in the severe PE group were shorter than those in the mild PE group, the INR decreased, and the FIB level increased; early-onset PE The PT and APTT of the late-onset PE group were shortened, the INR decreased, and the FIB level increased,the difference was statistically significant (P＜0.05); ROC analysis results showed that the AUCs of FIB alone and the four indicators combined to detect mild PE were 0.706 and 0.715 (P＜0.05); the AUCs of PT, APTT, FIB alone and the four indicators combined to detect severe PE were respectively They were 0.714, 0.672, 0.841, 0.905 (P＜0.05); the AUCs of PT, APTT, FIB alone and the combined detection of the four indicators to diagnose early-onset PE were 0.701, 0.669, 0.822, 0.885 (P＜0.05); FIB alone the AUC of the combined detection and four indicators for the diagnosis of late-onset PE were 0.735 and 0.768 (P＜0.05).Conclusion The combined detection of four coagulation indexes, PT, APTT, INR, and FIB, had a certain diagnostic value for the occurrence of mild PE, severe PE, early-onset PE, and late-onset PE, and had a higher diagnostic value for severe PE and early-onset PE.

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更新日期/Last Update: 1900-01-01