[1]王岳宸.度洛西汀治疗老年抑郁症的效果及对患者血清BDNF、5-TH、IL-18表达的影响[J].医学信息,2021,34(04):6-8.[doi:10.3969/j.issn.1006-1959.2021.04.002]
　WANG Yue-chen.The Effect of Duloxetine in the Treatment of Senile Depression and Its Influence on the Expression of Serum BDNF,5-TH and IL-18 in Patients[J].Medical Information,2021,34(04):6-8.[doi:10.3969/j.issn.1006-1959.2021.04.002]
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度洛西汀治疗老年抑郁症的效果及对患者血清BDNF、5-TH、IL-18表达的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年04期
页码:
6-8
栏目:
出版日期:
2021-02-15

文章信息/Info

Title:
The Effect of Duloxetine in the Treatment of Senile Depression and Its Influence on the Expression of Serum BDNF,5-TH and IL-18 in Patients
文章编号:
1006-1959（2021）04-0006-03
作者:
王岳宸
（佳木斯市中心医院药剂科，黑龙江 佳木斯 154002）
Author(s):
WANG Yue-chen
(Department of Pharmacy,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
度洛西汀; 抑郁症; BDNF; 5-TH; IL-18
Keywords:
Duloxetine; Depression; BDNF; 5-TH; IL-18
分类号:
R749.4
DOI:
10.3969/j.issn.1006-1959.2021.04.002
文献标志码:
A
摘要:
目的 分析度洛西汀治疗老年抑郁症的效果及对患者血清BDNF、5-TH、IL-18表达的影响。方法 选取2018年1月~2019年12月于本院诊治的老年抑郁症患者90例，采用随机数字表法分成对照组和观察组，每组45例。对照组给予舍曲林治疗，观察组给予度洛西汀治疗。比较两组抑郁状态评分、临床疗效、血清学指标和不良反应。结果 两组抑郁状态评分均降低，且观察组低于对照组，差异有统计学意义（P＜0.05）；观察组总有效率为95.56%，高于对照组的80.00%，差异有统计学意义（P＜0.05）；两组血清BDNF、5-TH水平均升高，IL-18水平均降低，且观察组血清BDNF、5-TH水平高于对照组，IL-18水平低于对照组，差异有统计学意义（P＜0.05）；观察组不良反应总发生率为13.33%，低于对照组的31.11%，差异有统计学意义（P＜0.05）。结论 度洛西汀治疗老年抑郁症效果确切，可减轻抑郁症状，上调血清BDNF、5-TH表达，下调IL-18表达，安全有效。
Abstract:
Objective To analyze the effect of duloxetine in the treatment of senile depression and its influence on the expression of serum BDNF, 5-TH and IL-18 in patients.Methods A total of 90 elderly depression patients who were diagnosed and treated in our hospital from January 2018 to December 2019 were selected and divided into a control group and an observation group using a random number table method, with 45 cases in each group.The control group was given sertraline treatment, and the observation group was given duloxetine treatment. The depression status scores, clinical efficacy, serological indicators and adverse reactions were compared between the two groups.Results The scores of depression in the two groups were reduced, and the observation group was lower than the control group, the difference was statistically significant (P＜0.05);The total effective rate of the observation group was 95.56%, which was higher than 80.00% of the control group,the difference was statistically significant (P＜0.05);The serum BDNF and 5-TH levels of the two groups increased, and the IL-18 levels decreased. The observation group’s serum BDNF and 5-TH levels were higher than those of the control group, and the IL-18 levels were lower than the control group,the difference was statistically significant(P＜0.05);The total incidence of adverse reactions in the observation group was 13.33%, which was lower than 31.11% in the control group,the difference was statistically significant(P＜0.05).Conclusion Duloxetine is effective in treating senile depression. It can relieve depressive symptoms, up-regulate the expression of serum BDNF and 5-TH, and down-regulate the expression of IL-18, which is safe and effective.

参考文献/References:

[1]高岩,赵亚明,马辛.米氮平与度洛西汀对老年抑郁症失眠者的疗效及5-HT的影响[J].西北药学杂志,2018,33(2):241-244. [2]哈保卫,杨拥军.度洛西汀联合认知行为干预治疗抑郁症的临床效果分析[J].国际精神病学杂志,2020,47(1):74-77. [3]陈丽萍,章明杰,郭操,等.度洛西汀与舍曲林治疗伴有躯体症状的老年性抑郁症的疗效评价[J].国际精神病学杂志,2018,45(6):1047-1049. [4]中华医学会精神病学分会.中国精神障碍分类与诊断标准第三版(精神障碍分类)[J].中华精神科杂志,2001,34(3):184-188. [5]胡湘.米那普仑与度洛西汀治疗抑郁症的疗效评价[J].中国现代药物应用,2020,14(10):176-177. [6]朱建峰,金卫东,孙峰俐.度洛西汀治疗抑郁症临床疗效及安全性国内研究的meta分析[J].中华行为医学与脑科学杂志,2018,27(9):858-864. [7]严贵亮,段建荣.度洛西汀对糖尿病伴发抑郁焦虑症状患者疗效的对照研究[J].精神医学杂志,2018,31(1):60-62. [8]张俊青,张增,蔡文文.米那普仑与度洛西汀治疗抑郁症的疗效和安全性评价[J].中国医院药学杂志,2019,39(21):2172-2175. [9]孟盼,柳卓,朱青,等.百事乐胶囊对抑郁模型大鼠海马隔颞轴BDNF、NT-3、NGF表达的影响[J].中国临床药理学与治疗学,2017,22(4):418-423. [10]李季,杨靖,刘安昌.度洛西汀与文拉法辛治疗老年抑郁症的疗效及对血清脑源性神经生长因子、5-羟色胺、去甲肾上腺素的影响[J].中国老年学杂志,2018,38(24):6012-6014. [11]赵指亮,谢飞,范大庆,等.高龄抑郁症患者血清BDNF、SP、IL-18表达水平分析[J].国际精神病学杂志,2019,46(1):63-65. [12]王梅,程韬,杨开仁,等.抑郁症患者血清脑源性神经生长因子、P物质、白细胞介素-6水平变化及临床意义[J].中国医药导报,2019,14(13):95-98. [13]金玲.艾司西酞普兰与氟西汀对抑郁症患者疗效及血清脑源性神经营养因子,炎性反应因子的影响[J].神经疾病与精神卫生,2019,19(7):692-696. [14]白红娟,郭宇鑫,马学银,等.解郁丸联合度洛西汀治疗抑郁症疗效及对血清神经递质及神经功能相关因子影响观察[J].药物流行病学杂志,2020,29(3):158-162. [15]郭玲玲,白青青,佟延新,等.老年抑郁症患者血清脑源性神经生长因子、P物质和白细胞介素-18的表达及意义[J].中国老年学杂志,2018,38(9):2155-2157.

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更新日期/Last Update: 1900-01-01