[1]赵 寻,朱家旺,张晓磊.支气管哮喘患者血清sICAM-1、IL-2、IL-4及HP变化及与肺功能的关系[J].医学信息,2021,34(11):105-107.[doi:10.3969/j.issn.1006-1959.2021.11.028]
　ZHAO Xun,ZHU Jia-wang,ZHANG Xiao-lei.Changes of Serum sICAM-1,IL-2,IL-4 and HP in Patients with Bronchial Asthma and Their Relationship with Lung Function[J].Medical Information,2021,34(11):105-107.[doi:10.3969/j.issn.1006-1959.2021.11.028]
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支气管哮喘患者血清sICAM-1、IL-2、IL-4及HP变化及与肺功能的关系()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年11期
页码:
105-107
栏目:
论著
出版日期:
2021-06-01

文章信息/Info

Title:
Changes of Serum sICAM-1,IL-2,IL-4 and HP in Patients with Bronchial Asthma and Their Relationship with Lung Function
文章编号:
1006-1959（2021）11-0105-03
作者:
赵 寻; 朱家旺; 张晓磊
（天津中医药大学第二附属医院急症科，天津 300150）
Author(s):
ZHAO Xun; ZHU Jia-wang; ZHANG Xiao-lei
(Department of Emergency Medicine,the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150,China)
关键词:
支气管哮喘; 可溶性细胞间黏附分子-1; 白细胞介素-2; 白细胞介素-4; 羟舖氨酸; 肺功能
Keywords:
Bronchial asthma; Soluble intercellular adhesion molecule-1; Interleukin-2;  Interleukin-4; Hydroxyplastine; Lung function
分类号:
R562.2+5
DOI:
10.3969/j.issn.1006-1959.2021.11.028
文献标志码:
A
摘要:
目的 探讨支气管哮喘患者血清可溶性细胞间黏附分子-1（sICAM-1）、白细胞介素-2（IL-2）、白细胞介素-4（IL-4）、羟舖氨酸（HP）的变化与患者肺功能的关系。方法 选取2017年1月~2019年8月我院确诊的支气管哮喘患者120例设为哮喘组，健康体检对象60名设为对照组，比较两组血清sICAM-1、IL-2、IL-4、HP水平及肺功能指标[第1秒用力呼气容积（FEV1）、用力肺活量（FVC）、最大呼气峰值流速（PEF）]，并分析哮喘组不同病情患者sICAM-1、IL-2、IL-4、HP水平，采用Pearson线性相关分析sICAM-1、IL-2、IL-4、HP水平及肺功能指标的关系。结果 哮喘组sICAM-1、IL-4及HP水平高于对照组，IL-2低于对照组，差异有统计学意义（P＜0.05）。哮喘组FEV1、FVC、PEF低于对照组，差异有统计学意义（P＜0.05）。急性发作期哮喘患者sICAM-1、IL-4及HP水平高于缓解期患者，IL-2水平低于缓解期患者（P＜0.05）。Pearson线性相关分析显示，急性期哮喘患者sICAM-1、IL-4及HP水平与FEV1、FVC、PEF均呈负相关，而IL-2水平与FEV1、FVC、PEF呈正相关（P＜0.05）。结论 支气管哮喘患者血清sICAM-1、IL-4及HP水平升高，IL-2水平降低，其引起的气道炎性表现与患者肺功能受损程度有关。
Abstract:
Objective To investigate the changes of serum soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-2 (IL-2), interleukin-4 (IL-4) and hydroxyplastine (HP) in patients with bronchial asthma The relationship with the patient’s lung function.Methods A total of 120 patients with bronchial asthma diagnosed in our hospital from January 2017 to August 2019 were selected as the asthma group, and 60 healthy subjects were selected as the control group.Compare the two groups of serum sICAM-1, IL-2, IL-4, HP levels and lung function indicators [forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), maximum peak expiratory flow rate (PEF)],and analyze the levels of sICAM-1, IL-2, IL-4, and HP in patients with different conditions in the asthma group.Pearson linear correlation was used to analyze the relationship among sICAM-1, IL-2, IL-4, HP levels and lung function indexes.Results The levels of sICAM-1, IL-4 and HP in the asthma group were higher than those in the control group, and IL-2 was lower than the control group, the difference was statistically significant (P<0.05).The FEV1, FVC and PEF of the asthma group were lower than those of the control group,the difference was statistically significant (P<0.05).The levels of sICAM-1, IL-4 and HP in patients with acute exacerbation were higher than those in remission, and the levels of IL-2 were lower than those in remission (P<0.05).Pearson linear correlation analysis showed that sICAM-1, IL-4, and HP levels in acute asthma patients were negatively correlated with FEV1, FVC, and PEF, while IL-2 levels were positively correlated with FEV1, FVC, and PEF (P<0.05).Conclusion The serum levels of sICAM-1, IL-4, and HP in patients with bronchial asthma are increased, while the level of IL-2 is decreased. The airway inflammation caused by them is related to the degree of lung function impairment.

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更新日期/Last Update: 1900-01-01