[1]高 山.盐酸氨溴索治疗老年慢阻肺合并肺部感染临床效果[J].医学信息,2021,34(11):158-160.[doi:10.3969/j.issn.1006-1959.2021.11.044]
　GAO Shan.Clinical Effect of Ambroxol Hydrochloride in the Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease and Pulmonary Infection[J].Medical Information,2021,34(11):158-160.[doi:10.3969/j.issn.1006-1959.2021.11.044]
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盐酸氨溴索治疗老年慢阻肺合并肺部感染临床效果()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年11期
页码:
158-160
栏目:
药物与临床
出版日期:
2021-06-01

文章信息/Info

Title:
Clinical Effect of Ambroxol Hydrochloride in the Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease and Pulmonary Infection
文章编号:
1006-1959（2021）11-0158-03
作者:
高 山
（天津港口医院呼吸内科，天津 300450）
Author(s):
GAO Shan
(Department of Respiratory Medicine,Tianjin Port Hospital,Tianjin 300450,China)
关键词:
盐酸氨溴索; 慢阻肺; 肺部感染
Keywords:
Ambroxol hydrochloride; Chronic obstructive pulmonary disease; Pulmonary infection
分类号:
R563.1
DOI:
10.3969/j.issn.1006-1959.2021.11.044
文献标志码:
A
摘要:
目的 探讨盐酸氨溴索治疗老年慢阻肺合并肺部感染临床效果。方法 选取2018年1月~2020年8月在我院治疗的240例慢阻肺合并肺部感染老年患者为研究对象，采用随机数字表法分为对照组和观察组，各120例。对照组采用常规治疗，观察组在常规治疗基础上联合盐酸氨溴索治疗，比较两组临床治疗总有效率、临床症状改善时间、肺部感染评分（CPIS）、肺功能指标以及临床不良反应发生情况。结果 观察组治疗总有效率为94.16%，与对照组的84.16%比较，差异无统计学意义（P＞0.05）；观察组呼吸困难、胸闷、咯痰、咳嗽症状改善时间短于对照组，差异有统计意义（P＜0.05）；治疗后两组CPIS评分低于治疗前，且观察组低于对照组，差异有统计意义（P＜0.05）；治疗后两组VCmax、FEV1%高于治疗前，且观察组高于对照组，差异有统计意义（P＜0.05）；两组临床不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 盐酸氨溴索治疗老年慢阻肺合并肺部感染效果确切，总有效率高，临床症状减轻，肺功能明显改善，且不良反应少。
Abstract:
Objective To investigate the clinical effect of ambroxol hydrochloride in the treatment of elderly patients with chronic obstructive pulmonary disease and pulmonary infection.Methods 240 elderly patients with chronic obstructive pulmonary disease and pulmonary infection who were treated in our hospital from January 2018 to August 2020 were selected as the research objects.Using random number table method, they were divided into control group and observation group, each with 120 cases.The control group was treated with conventional treatment, and the observation group was treated with ambroxol hydrochloride on the basis of conventional treatment. The total effective rate of clinical treatment, clinical symptom improvement time, pulmonary infection score (CPIS), pulmonary function indicators, and occurrence of clinical adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.16%, compared with 84.16% in the control group, the difference was not statistically significant (P＞0.05);The time to improve the symptoms of dyspnea, chest tightness, expectoration and cough in the observation group was shorter than that in the control group,the difference was statistically significant (P＜0.05);After treatment, the CPIS scores of the two groups were lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant (P＜0.05);After treatment, VCmax and FEV1% of the two groups were higher than before treatment, and the observation group was higher than the control group, the difference was statistically significant (P＜0.05);There was no statistically significant difference in the incidence of clinical adverse reactions between the two groups (P＞0.05).Conclusion Ambroxol hydrochloride has a definite effect in the treatment of elderly chronic obstructive pulmonary disease with pulmonary infection. The total effective rate is high, the clinical symptoms are alleviated, the lung function is significantly improved, and the adverse reactions are few.

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更新日期/Last Update: 1900-01-01