[1]郭 丽,黄淑娟,隋红梅.子痫前期的药物预防研究[J].医学信息,2023,36(23):170-173,183.[doi:10.3969/j.issn.1006-1959.2023.23.043]
　GUO Li,HUANG Shu-juan,SUI Hong-mei.Research on Drug Prevention of Preeclampsia[J].Journal of Medical Information,2023,36(23):170-173,183.[doi:10.3969/j.issn.1006-1959.2023.23.043]
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子痫前期的药物预防研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年23期
页码:
170-173,183
栏目:
综述
出版日期:
2023-12-01

文章信息/Info

Title:
Research on Drug Prevention of Preeclampsia
文章编号:
1006-1959（2023）23-0170-05
作者:
郭 丽; 黄淑娟; 隋红梅
（天津中医药大学附属北辰中医院产科，天津 300400）
Author(s):
GUO Li; HUANG Shu-juan; SUI Hong-mei
(Obstetrics Department of Beichen Hospital of Traditional Chinese Medicine Affiliated to Tianjin Universityof Traditional Chinese Medicine,Tianjin 300400,China)
关键词:
子痫前期; 妊娠期并发症; 蛋白尿
Keywords:
Preeclampsia; Pregnancy complications; Proteinuria
分类号:
R714.24+4
DOI:
10.3969/j.issn.1006-1959.2023.23.043
文献标志码:
A
摘要:
子痫前期是临床常见的妊娠期并发症，临床患者多在妊娠20周以后，表现出血压升高、蛋白尿、头痛、视力模糊、上腹痛、少尿等症状。子痫前期发病机制复杂，目前临床尚未完全明确。子痫前期是妊娠期所特有疾病，是临床导致围产期孕产妇和新生儿病死的主要原因。因此，正确认识子痫前期，早期给予有效的预防，对降低子痫前期危害，改善母儿结局具有重要的意义。本文从子痫前期发病机制入手，综述药物干预研究情况，为临床子痫前期预防提供一定的参考依据。
Abstract:
Preeclampsia is a common clinical complication of pregnancy. Clinical patients are mostly after 20 weeks of pregnancy, mainly manifested as elevated blood pressure, proteinuria, headache, blurred vision, upper abdominal pain, oliguria and other symptoms. The pathogenesis of preeclampsia is complex, and the clinical is not yet fully clear. Preeclampsia is a unique disease during pregnancy and is the main cause of perinatal maternal and neonatal death. Therefore, a correct understanding of preeclampsia and early effective prevention are of great significance for reducing the harm of preeclampsia and improving the outcome of mothers and infants. In this paper, starting from the pathogenesis of preeclampsia, the research progress of drug intervention is reviewed to provide some reference for clinical prevention of preeclampsia.

参考文献/References:

[1]刘洋铭,车平,袁雨,等.ACK1在子痫前期孕妇胎盘中的表达及其对滋养细胞侵袭功能的调控[J].重庆医科大学学报,2019,44(6):728-733.[2]Mischi M,Chen C,Ignatenko T,et al.Dedicated entropy measures for early assessment of pregnancy progression from singlechannel electrohysterography[J].IEEE Trans Biomed Eng,2018,65(4):875-884.[3]王彤洁.血管内皮生长因子及其受体在子痫前期早期诊断中的价值[J].山西医药杂志,2016,45(24):2904-2906.[4]杨建会,宋光辉,潘子红,等.轻重度子痫前期孕妇胎盘中维生素E及氧化应激损伤指标的监测[J].中国妇幼保健,2018,33(15):3429-3431.[5]Zhou Y,Li H,Zhang Y,et al.Rate of gestational weight gain and adverse pregnancy outcomes in rural nulliparous women:a prospective cohort analysis from China[J].Br J Nutr,2019,14(3):1-8.[6]葛会生,王寒冰,黄冬妮,等.IL-27通过JAK2/STAT1信号通路影响血管内皮细胞功能参与子痫前期发病机制的相关研究[J].重庆医科大学学报,2019,44(1):1-5.[7]耿彬.脂肪内源性硫化氢-功能、调节与疾病[J].生理科学进展,2017,48(1):37-41.[8]刘霞.子痫前期孕妇sEng、VEGF、PLGF、sFlt-1水平与脐动脉血流变化[J].海南医学院学报,2016,22(8):774-776.[9]吴瑞凤,杨琦芳,田晓艳.硫酸镁对子痫前期模型大鼠胎盘功能以及子代发育性高血压和肠系膜动脉功能障碍的影响[J].临床和实验医学杂志,2022,21(21):2253-2257.[10]白莹,孙静莉.母鼠子痫前期炎症刺激致子鼠肾脏发育不良的作用机制研究[J].解放军医药杂志,2022,34(7):16-20.[11]俎维华.CsA对L-NAME诱导的子痫前期小鼠模型治疗作用的初步探讨[D].海口:海南医学院,2022. [12]刘雨.HO-1-hPMSCs改善L-NAME诱导的子痫前期大鼠模型症状和妊娠结局的动物实验研究[D].武汉:华中科技大学,2021.[13]肖学红.子痫前期患者血脂代谢、外周血sFlt-1、sEng水平变化及其相关性[J].中国计划生育学杂志,2022,30(7):1631-1634.[14]郭红霞,高冰心,陈绍云,等.子痫前期小鼠肾脏Perlecan蛋白表达对血管内皮生成的影响研究[J].中国实用妇科与产科杂志,2021,37(5):592-594.[15]Okwudire EG,Atalabi OM,Ezenwugo UM.The use of uterine artery doppler indices for prediction of pre-eclampsia in Port-Harcourt,Nigeria[J].Niger Postgrad Med J,2019,26(4):223-229.[16]王芙蓉,严谨,贺丰杰.普伐他汀激活子痫前期小鼠MAP K抗凋亡信号通路[J].基础医学与临床,2021,41(8):1109-1113.[17]王志尹.普伐他汀抑制LPS诱导的人绒毛外滋养细胞miR-155表达并改善滋养细胞功能[D].南京:南京医科大学,2018. [18]郑雯娜,邓星梅,唐淞源.不同孕周使用小剂量阿司匹林预防子痫前期的临床应用[J].昆明医科大学学报,2020,41(10):134-137.[19]冯小丹,单委.低剂量阿司匹林对轻度子痫前期孕妇凝血功能及血清IL-6、TNF-α、COX-2、TXA2水平的影响[J] 新疆医科大学学报,2022,45(8):863-866,879.[20]魏清敏,米阳,程百茹.低分子肝素钙联合阿司匹林治疗早发型重度子痫前期的临床效果研究[J].延安大学学报(医学科学版),2018,16(4):31-34,48.[21]李帆,徐佳,闫晋琪.小剂量阿司匹林联合维生素E预防子痫前期高危孕妇临床效果[J].中国计划生育学杂志,2022,30(7):1555-1559.[22]马玲,马荣虎,樊杨.阿司匹林用于预防子痫前期及改善母儿结局的临床研究[J].甘肃科技,2022,38(12):88-91.[23]张璐.子痫前期高危人群阿司匹林精准治疗策略探讨[D].天津:天津医科大学,2020.[24]张琚芳,吴菲菲,朱启英.小剂量阿司匹林在子痫前期高危患者中的应用效果及可能机制探讨[J].中国计划生育和妇产科,2022,14(3):26-30.[25]李仲均,黄丽珊,曾带娣,等.孕妇维生素A、E水平与子痫前期的相关性[J].实用医学杂志,2018,34(24):4076-4079.[26]郑福利,杨静,张娜,等.妊娠中期血清维生素水平与子痫前期及不良妊娠结局的关系[J].中国医药,2022,17(12):1832-1836. [27]李金波,李汪俊,任庆文,等.孕期膳食维生素C摄入与子痫前期及其临床亚型的关系[J].中华疾病控制杂志,2022,26(9):1023-1029,1096.[28]余敏,王娜,胡丽,等.阿司匹林+低分子肝素对子痫前期孕妇妊娠结局胎盘血流灌注及内皮损伤的临床研究[J].中国妇幼保健,2022,37(13):2377-2380.[29]徐畅,王秋实.低分子量肝素对子痫前期产妇产后凝血指标的影响[J].临床输血与检验,2022,24(1):28-32.[30]郭玉惠,徐巍.早发型子痫前期患者再次妊娠预防性应用低分子肝素的临床效果[J].临床医学,2022,42(1):111-113.[31]吴惠珍,吴惠子,杨力,等.25-羟维生素D及钙离子与子痫前期的相关性研究[J].右江医学,2018,46(4):393-396.[32]王璐婕,孟柳.血清25-羟基维生素D钙离子水平对子痫前期发生及发展程度的预测价值[J].中国药物与临床,2022,22(4):350-352.[33]樊凌云,张华,杨玉侠,等.硫酸镁负荷疗法治疗子痫前期对血液流变学的影响[J].河北医药,2022,44(9):1375-1377,1381.[34]陈春玲,邓艳浓,陈锦玉.活血化瘀法对子痫前期的治疗作用及其凝血功能的影响[J].中医临床研究,2016,8(20):15-18.[35]贾锐,李建武,刘丽霞,等.滋肾清肝化淤方联合阿司匹林治疗子痫前期疗效及安全性研究[J].陕西中医,2019,40(6):749-752.[36]陈蓉,尧小云.丹参川芎嗪注射液联合常规治疗对妊娠期高血压－子痫前期患者的临床疗效[J].中成药,2019,41(11):2637-2642.

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更新日期/Last Update: 1900-01-01