[1]季 磊,单慧敏,王银香,等.基于网络药理学研究鸡血藤治疗胃癌的作用机制[J].医学信息,2024,37(16):7-11.[doi:10.3969/j.issn.1006-1959.2024.16.002]
　JI Lei,SHAN Hui-min,WANG Yin-xiang,et al.Study on the Mechanism of Suberect Spatholobus Stem in the Treatment of Gastric CancerBased on Network Pharmacology[J].Journal of Medical Information,2024,37(16):7-11.[doi:10.3969/j.issn.1006-1959.2024.16.002]
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基于网络药理学研究鸡血藤治疗胃癌的作用机制()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年16期
页码:
7-11
栏目:
中医药信息学
出版日期:
2024-08-15

文章信息/Info

Title:
Study on the Mechanism of Suberect Spatholobus Stem in the Treatment of Gastric CancerBased on Network Pharmacology
文章编号:
1006-1959（2024）16-0007-05
作者:
季 磊1; 单慧敏2; 王银香1; 孙志勤1; 翟长云1; 王晋秋1
盐城市大丰人民医院/扬州大学医学院大丰临床学院肿瘤科1，病理科2，江苏 盐城 224005
Author(s):
JI Lei1; SHAN Hui-min2; WANG Yin-xiang1; SUN Zhi-qin1; ZHAI Chang-yun1; WANG Jin-qiu1
Department of Oncology1,Department of Pathology2,Yancheng Dafeng People’s Hospital/Dafeng Clinical College,Yangzhou University School of Medicine,Yancheng 224005,Jiangsu,China
关键词:
网络药理学; 鸡血藤; 胃癌
Keywords:
Network pharmacology; Suberect Spatholobus Stem; Gastric cancer
分类号:
R273
DOI:
10.3969/j.issn.1006-1959.2024.16.002
文献标志码:
A
摘要:
目的 借助网络药理学预测鸡血藤治疗胃癌的潜在作用机制。方法 通过TCMSP数据库获得鸡血藤的活性成分及对应靶点，同时利用GeneCards、TTD和OMIM等数据库收集胃癌靶点。采用韦恩图得到药物和疾病交集靶点，通过STRING数据库构建交集靶点蛋白相互作用网络（PPI）。运用DAVID在线工具对交集靶点进行GO功能和KEGG通路富集分析。结果 获得鸡血藤有效活性成分共24个，对应靶点104个，收集胃癌靶点共1639个，通过Venn图得到鸡血藤-胃癌交集靶点共66个。蛋白相互作用网络分析得到TP53、STAT3、AKT1、CASP3和TNF等关键靶点。GO富集分析得到生物过程条目489个、细胞组成条目45个和分子功能条目89个；KEGG通路富集分析得到159条信号通路，其中通路主要与PIK3-Akt信号通路、IL-17信号通路和HIF-1信号通路等密切相关。结论 基于网络药理学初步揭示鸡血藤抗肿瘤可能通过调节TP53、STAT3、AKT1、CASP3和TNF等关键蛋白，干扰PIK3-Akt信号通路、IL-17信号通路和HIF-1信号通路等发挥作用。
Abstract:
Objective To predict the potential mechanism of Suberect Spatholobus Stem in the treatment of gastric cancer by network pharmacology.Methods The active components and corresponding targets of Suberect Spatholobus Stem were obtained by TCMSP database, and the gastric cancer targets were collected by GeneCards, TTD and OMIM databases. The intersection targets of drugs and diseases were obtained by Wayne diagram, and the intersection target protein interaction network (PPI) was constructed by STRING database. The GO function and KEGG pathway enrichment analysis of the intersection targets were performed using the DAVID online tool.Results A total of 24 active components of Suberect Spatholobus Stem were obtained, corresponding to 104 targets, and a total of 1639 gastric cancer targets were collected. A total of 66 intersection targets of Suberect Spatholobus Stem-gastric cancer were obtained by Venn diagram. Key targets such as TP53, STAT3, AKT1, CASP3 and TNF were obtained by protein interaction network analysis. GO enrichment analysis obtained 489 biological process items, 45 cell composition items and 89 molecular function items. KEGG pathway enrichment analysis obtained 159 signaling pathways, among which the pathways were mainly closely related to PIK3-Akt signaling pathway, IL-17 signaling pathway and HIF-1 signaling pathway.Conclusion Based on network pharmacology, it is preliminarily revealed that Suberect Spatholobus Stem anti-tumor may play a role by regulating key proteins such as TP53, STAT3, AKT1, CASP3 and TNF, and interfering with PIK3-Akt signaling pathway, IL-17 signaling pathway and HIF-1 signaling pathway.

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更新日期/Last Update: 1900-01-01