[1]李名洪,刘 俊,陈玉萍.早期预警评分联合CRP在高脂血症性胰腺炎严重程度及预后中的临床价值[J].医学信息,2025,38(07):105-108.[doi:10.3969/j.issn.1006-1959.2025.07.019]
　LI Minghong,LIU Jun,CHEN Yuping.Clinical Value of Early Warning Score Combined with CRP in the Severity and Prognosis of Hyperlipidemic Pancreatitis[J].Journal of Medical Information,2025,38(07):105-108.[doi:10.3969/j.issn.1006-1959.2025.07.019]
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早期预警评分联合CRP在高脂血症性胰腺炎严重程度及预后中的临床价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年07期
页码:
105-108
栏目:
论著
出版日期:
2025-04-01

文章信息/Info

Title:
Clinical Value of Early Warning Score Combined with CRP in the Severity and Prognosis of Hyperlipidemic Pancreatitis
文章编号:
1006-1959（2025）07-0105-04
作者:
李名洪; 刘 俊; 陈玉萍
上犹县人民医院急诊科，江西 上犹 341200
Author(s):
LI Minghong;  LIU Jun;  CHEN Yuping
Emergency Department of Shangyou County People’s Hospital, Shangyou 341200, Jiangxi, China
关键词:
高脂血症性胰腺炎; C反应蛋白; 早期预警评分; 预后不良; 预测价值; 敏感度
Keywords:
Hyperlipidemic pancreatitis;  C-reactive protein;  Early warning score;  Poor prognosis;  Predictive value;  Sensitivity
分类号:
R657.5+1
DOI:
10.3969/j.issn.1006-1959.2025.07.019
文献标志码:
A
摘要:
目的 探究早期预警（NEWS）评分联合C反应蛋白（CRP）对高脂血症性胰腺炎（HLP）病情严重程度及预后的评估价值。方法 纳入2020年5月-2023年7月上犹县人民医院收治的66例HLP患者，依据其病情严重程度分为轻度组（32例）、中度组（20例）、重度组（14例），检测其血清CRP水平，完成NEWS量表评分，并进行预后观察，比较轻度组、中度组、重度组的CRP水平及NEWS评分，分析CRP、NEWS评分与HLP病情严重程度的相关性，比较预后不良与预后良好患者的CRP和NEWS评分，分析CRP联合NEWS评分对HLP患者预后不良的预测价值。结果 三组CRP水平及NEWS评分比较，差异有统计学意义（P＜0.05），其中CRP水平及NEWS评分由低到高依次为轻度组＜中度组＜重度组。Spearman相关性分析显示，CRP水平、NEWS评分与HLP病情严重程度呈正相关（P＜0.05）。预后不良组CRP水平、NEWS评分高于预后良好组（P＜0.05）。ROC曲线显示，CRP联合NEWS评分预测HLP预后不良的AUC、敏感度、特异度大于二者单独检测（P＜0.05）。结论 CRP水平、NEWS评分与HLP病情严重程度存在相关性，二者联合检测对HLP预后结局具有较高的预测价值。
Abstract:
Objective To explore the value of early warning (NEWS) score combined with C-reactive protein (CRP) in evaluating the severity and prognosis of hyperlipidemic pancreatitis (HLP). Methods A total of 66 patients with HLP admitted to Shangyou County People’s Hospital from May 2020 to July 2023 were divided into mild group (32 patients), moderate group (20 patients) and severe group (14 patients) according to the severity of the disease. The serum CRP level was detected, the NEWS scale score was completed, and the prognosis was observed. The CRP level and NEWS score of mild group, moderate group and severe group were compared. The correlation between CRP and NEWS score and the severity of HLP was analyzed. The CRP and NEWS scores of patients with poor prognosis and good prognosis were compared. The predictive value of CRP combined with NEWS score for poor prognosis in patients with HLP was analyzed. Results There were statistically significant differences in CRP level and NEWS score among the three groups (P<0.05). The CRP level and NEWS score from low to high were mild group

参考文献/References:

[1]王建强,李迎敏,杨小庆.高脂血症性胰腺炎患者血浆中Ca2+、C-反应蛋白及纤维蛋白原水平变化及其临床意义[J].川北医学院学报,2023,38(12):1693-1696.[2]刘娜,邹爱民,韩双,等.血清SAA、CRP、PCT、IL-6水平与急性胰腺炎患者病情严重程度及预后的相关性分析[J].检验医学与临床,2023,20(3):379-382.[3]汪海平,李贺.CRP、NLR对不同病因引起的重症急性胰腺炎预测价值研究[J].中国急救复苏与灾害医学杂志,2023,18(8):1069-1073.[4]李歌,田霞.血清hs-CRP PCT RDW和NRBC水平在重症急性胰腺炎患者中的表达水平及意义[J].河北医学,2023,29(5):762-767.[5]李静,孟文勤,张江英,等.炎症因子表达水平与重症急性胰腺炎预后及肠道屏障损伤的相关性[J].现代生物医学进展,2023,23(9):1726-1730. [6]章勤,王莉,徐帅帅.妊娠合并急性胰腺炎患者血清降钙素原 C-反应蛋白水平变化及NEWS早期预警评分的临床意义[J].中国妇幼保健,2023,38(8):1373-1378. [7]Lahan K,Sonowal N,Teli BA,et al.C-reactive protein and modified computed tomography severity index in assessing severity of acute pancreatitis[J].Asian Journal of Medical Sciences,2023,14(2):202-207.[8]李非,曹锋.中国急性胰腺炎诊治指南（2021）[J].中国实用外科杂志,2021,41(7):739-746.[9]金秋,杨婧,马红琳,等.不同评分系统预测高脂血症性急性胰腺炎严重程度及预后的价值分析[J].临床肝胆病杂志,2022,38(11):2551-2557.[10]郭振科,李新.HAP评分联合BISAP评分及D-二聚体检测对重症急性胰腺炎有较高的预后评估价值[J].内科急危重症杂志,2022,28(1):58-60.[11]则学英,安春霞,刘磊,等.重症急性胰腺炎合并腹腔感染患者血清Ghrelin、AMS、hs-CRP的表达水平及预后价值分析[J].中国现代医学杂志,2021,31(24):42-49.[12]高亚洲,徐之超,殷国志.CT评分联合CRP检测评估重症急性胰腺炎的预后价值分析[J].中国CT和MRI杂志,2022,20(1):122-124.[13]陈梦婷,余清萍,李雨,等.血清PCT、NLR及CRP水平与急性胰腺炎严重程度的相关性[J].西部医学,2021,33(12):1849-1853.[14]李彬龙,师娜,刘婷.重症急性胰腺炎患者血清SAA、CRP、ACE2水平变化及临床意义[J].海南医学,2021,32(15):1942-1945.[15]安文慧,何旭昶,杨婧,等.入院早期评分系统对急性胰腺炎严重程度及预后的预测价值[J].临床肝胆病杂志,2020,36(6):1342-1346.[16]刘胜,唐豪佑,胡程郡,等.早期评分系统联合CRP对急性胰腺炎合并肺部感染早期诊断及预后的预测价值[J].中国普外基础与临床杂志,2021,28(6):737-742.[17]任盼盼,姚喜庆,周伟,等.影响高脂血症性胰腺炎病情程度的因素分析[J].蚌埠医学院学报,2020,45(10):1367-1369,1374.[18]李小锋,曹小平,龚君佐,等.血清PCT、CRP、IL-6对急性胰腺炎病情严重性及预后判断[J].湖南师范大学学报(医学版),2020,17(4):106-109.[19]赵凯,章阳.血清淀粉样蛋白A、CRP和PCT水平预测高脂血症性急性胰腺炎严重程度及预后的临床价值[J].标记免疫分析与临床,2021,28(2):268-272.[20]徐霞,黄象维,赖媚媚.降钙素原、C-反应蛋白、中性粒细胞与淋巴细胞比值在评估急性胰腺炎严重程度和预后中的临床价值[J].中国卫生检验杂志,2022,32(24):3032-3035,3042.[21]张贵真.血清PCT、CRP检测对重症急性胰腺炎合并细菌感染的诊断价值[J].肝胆外科杂志,2020,28(1):49-52.[22]陈辉,兰涛,张培君,等.BISAP、Ranson和APACHEⅡ评分系统对高脂血症性急性胰腺炎患者病情和预后的评估价值[J].现代生物医学进展,2020,20(2):361-365,396. [23]李莉,宁华英,刘晖,等.重症急性胰腺炎患者营养风险筛查与临床结局的相关性及价值探讨[J].重庆医学,2020,49(9):1413-1416.[24]左艳艳,李云伟,康焰.三种评分系统对重症急性胰腺炎患者预后预测价值的比较[J].华西医学,2019,34(11):1233-1238.[25]陈秋星,王高生,赵涛,等.改良早期预警评分对重症急性胰腺炎并发急性肺损伤患者病情评估和预后的预测价值[J].临床急诊杂志,2019,20(7):513-516.[26]王勇,刘志.英国国家早期预警评分对急性胰腺炎的早期评估[J].中国医师进修杂志,2019,42(1):54-57.

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更新日期/Last Update: 1900-01-01