[1]胡旭颖.氯吡格雷联合阿司匹林治疗老年冠心病的临床疗效及对血清D-二聚体、NT-proBNP水平的影响[J].医学信息,2025,38(18):91-94.[doi:10.3969/j.issn.1006-1959.2025.18.020]
　HU Xuying.Clinical Efficacy of Clopidogrel Combined with Aspirin in the Treatment of Elderly Patientswith Coronary Heart Disease and its Effect on Serum D-dimer and NT-proBNP Levels[J].Journal of Medical Information,2025,38(18):91-94.[doi:10.3969/j.issn.1006-1959.2025.18.020]
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氯吡格雷联合阿司匹林治疗老年冠心病的临床疗效及对血清D-二聚体、NT-proBNP水平的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年18期
页码:
91-94
栏目:
论著
出版日期:
2025-09-15

文章信息/Info

Title:
Clinical Efficacy of Clopidogrel Combined with Aspirin in the Treatment of Elderly Patientswith Coronary Heart Disease and its Effect on Serum D-dimer and NT-proBNP Levels
文章编号:
1006-1959（2025）18-0091-04
作者:
胡旭颖
定南县第一人民医院药剂科，江西 定南 341900
Author(s):
HU Xuying
Department of Pharmacy, Dingnan County First People’s Hospital, Dingnan 341900, Jiangxi, China
关键词:
冠心病; 老年; 双联抗血小板; 氯吡格雷; 阿司匹林; D-二聚体; NT-proBNP; 血液流变学; 心功能
Keywords:
Coronary heart disease;  The elderly;  Dual antiplatelet therapy;  Clopidogrel;  Aspirin;  D-dimer;  NT-proBNP;  Hemorheology;  Cardiac function
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2025.18.020
文献标志码:
A
摘要:
目的 探究氯吡格雷联合阿司匹林治疗老年冠心病（CHD）的临床价值。方法 以2021年1月-2023年12月定南县第一人民医院收治的60例老年CHD患者为研究对象，经随机数字表法分为单抗组（30例）与双抗组（30例），两组均给予常规治疗，在此基础上，单抗组采用阿司匹林抗血小板治疗，双抗组采用氯吡格雷联合阿司匹林抗血小板治疗，比较两组临床疗效、血液流变学指标[血细胞比容（HCT）、血小板压积（PCT）]、心功能指标[左心室射血分数（LVEF）、左室舒张末内径（LVDD）]、血清D-二聚体（D-D）、氨基末端-B 型利钠肽前体（NT-proBNP）水平、不良反应。结果 双抗组临床改善率高于单抗组（P＜0.05）。两组治疗后HCT、PCT指标低于治疗前，且双抗组HCT、PCT指标低于单抗组（P＜0.05）。两组治疗后LVEF大于治疗前、LVDD小于治疗前，且双抗组LVEF大于单抗组、LVDD小于单抗组（P＜0.05）。两组治疗后血清D-D、NT-proBNP水平低于治疗前，且双抗组血清D-D、NT-proBNP水平低于单抗组（P＜0.05）。两组不良反应发生率对比，差异无统计学意义（P＞0.05）。结论 氯吡格雷联合阿司匹林在老年CHD患者中具有确切应用效果，可提升其临床疗效，改善患者血液流变学与心功能指标，下调血清D-D、NT-proBNP水平，安全性佳。
Abstract:
Objective To explore the clinical value of clopidogrel combined with aspirin in the treatment of elderly patients with coronary heart disease (CHD). Methods Sixty elderly patients with CHD admitted to Dingnan County First People’s Hospital from January 2021 to December 2023 were enrolled in the study. They were divided into monoclonal antibody group (30 patients) and double antibody group (30 patients) by random number table method. Both groups were given conventional treatment. On this basis, the monoclonal antibody group was treated with aspirin antiplatelet therapy, and the double antibody group was treated with clopidogrel combined with aspirin antiplatelet therapy. The clinical efficacy, hemorheology indexes [hematocrit (HCT), plateletcrit (PCT)], cardiac function indexes [left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVDD)], serum D-dimer (D-D), N-terminal B-type natriuretic peptide precursor (NT-proBNP) levels and adverse reactions were compared between the two groups. Results The clinical improvement rate of the double antibody group was higher than that of the monoclonal antibody group (P<0.05). The HCT and PCT indexes of the two groups after treatment were lower than those before treatment, and the HCT and PCT indexes of the double antibody group were lower than those of the monoclonal antibody group (P<0.05). After treatment, LVEF in the two groups was higher than that before treatment, LVDD was lower than that before treatment, and LVEF in the double antibody group was higher than that in the monoclonal antibody group, LVDD was lower than that in the monoclonal antibody group (P<0.05). After treatment, the levels of serum D-D and NT-proBNP in the two groups were lower than those before treatment, and the levels of serum D-D and NT-proBNP in the double antibody group were lower than those in the monoclonal antibody group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Clopidogrel combined with aspirin has a definite application effect in elderly patients with CHD, which can improve its clinical efficacy, improve hemorheology and cardiac function indexes, and down-regulate serum D-D and NT-proBNP levels, with good safety.

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更新日期/Last Update: 1900-01-01