[1]黄美英,符 奇.奥氮平与阿立哌唑治疗首发精神分裂症的效果及其对患者认知功能的影响[J].医学信息,2020,33(21):149-151.[doi:10.3969/j.issn.1006-1959.2020.21.046]
　HUANG Mei-ying,FU Qi.The Effect of Olanzapine and Aripiprazole in the Treatment of First-episode Schizophrenia and Its Influence on Patients’ Cognitive Function[J].Medical Information,2020,33(21):149-151.[doi:10.3969/j.issn.1006-1959.2020.21.046]
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奥氮平与阿立哌唑治疗首发精神分裂症的效果及其对患者认知功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年21期
页码:
149-151
栏目:
药物与临床
出版日期:
2020-11-01

文章信息/Info

Title:
The Effect of Olanzapine and Aripiprazole in the Treatment of First-episode Schizophrenia and Its Influence on Patients’ Cognitive Function
文章编号:
1006-1959（2020）21-0149-03
作者:
黄美英; 符 奇
（上饶市第三人民医院精神一科1，精神四科2，江西 上饶 334000）
Author(s):
HUANG Mei-ying; FU Qi
(Department of Psychiatry,Subject One1,Subject Four2,Shangrao Third People’s Hospital,Shangrao 334000,Jiangxi,China)
关键词:
奥氮平; 阿立哌唑; 首发精神分裂症; 认知功能
Keywords:
Olanzapine; Aripiprazole; First-episode schizophrenia; Cognitive function
分类号:
R749.3
DOI:
10.3969/j.issn.1006-1959.2020.21.046
文献标志码:
A
摘要:
目的 观察奥氮平联合阿立哌唑治疗首发精神分裂症的效果及对患者认知功能的影响。方法 选取我院2017年12月~2019年12月收治的76例精神分裂症患者作为研究对象，根据随机数字表法分为A组（n=39）和B组（n=37），A组采用奥氮平治疗，B组采用阿立哌唑治疗。比较两组精神症状评分（阴性症状评分、阳性症状评分、一般病理症状、PANSS总分）、临床疗效及认知功能。结果 两组治疗前及治疗后精神症状评分比较，差异无统计学意义（P＞0.05）；治疗后两组精神症状评分均低于治疗前（P＜0.05）。A组治疗总有效率为82.05%，与B组的81.08%比较，差异无统计学意义（P＞0.05）；治疗后，A组记忆能力及词语学习（HVLT-R）、记忆能力及视觉学习（BVMT-R）、非词语工作记忆能力（SSS顺行、SSS逆行）认知评分均低于B组，DST评分高于B组(P＜0.05)；两组选择性注意领域（SCT、SWT、SCWT）、VF认知评分比较，差异无统计学意义（P＞0.05）。结论 奥氮平与阿立哌唑均可改善患者的精神症状，阿立哌唑侧重于改善患者的词语学习及记忆能力、视觉学习及记忆能力及非词语工作记忆能力，奥氮平侧重于改善患者信息处理速度，建议临床根据患者实际情况酌情用药。
Abstract:
Objective To observe the effect of olanzapine combined with aripiprazole in the treatment of first-episode schizophrenia and its influence on patients’ cognitive function.Methods A total of 76 patients with schizophrenia admitted to our hospital from December 2017 to December 2019 were selected as the research objects. According to the random number table method, they were divided into group A(n=39) and group B(n=37), group A Olanzapine was used for treatment, and group B was treated with aripiprazole. The psychiatric symptom scores (negative symptom score, positive symptom score, general pathological symptoms, PANSS total score), clinical efficacy and cognitive function were compared between the two groups.Results There was no significant difference in the scores of psychiatric symptoms between the two groups before and after treatment (P＞0.05); the scores of psychiatric symptoms in the two groups after treatment were lower than those before treatment(P＜0.05). The total effective rate of treatment in group A was 82.05%, compared with 81.08% in group B, the difference was not statistically significant (P＞0.05); after treatment, memory ability and word learning (HVLT-R), memory ability and visual learning in group A (BVMT-R), non-verbal working memory (SSS anterograde and SSS retrograde) cognitive scores were lower than group B, DST score was higher than group B(P＜0.05); There was no statistically significant difference between the two groups of selective attention areas (SCT, SWT, SCWT) and VF cognitive scores (P＞0.05).Conclusion Both olanzapine and aripiprazole could improve the mental symptoms of patients. Aripiprazole focused on improving the patient’s vocabulary learning and memory ability, visual learning and memory ability, and non-verbal working memory ability, while olanzapine focused on improvement For the speed of patient information processing, it was recommended that the clinic use drugs according to the actual situation of the patient.

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更新日期/Last Update: 1900-01-01