[1]李清河,廖玲玲,汪红艳.凝血指标对食管鳞癌预后的影响因素分析[J].医学信息,2021,34(24):33-38.[doi:10.3969/j.issn.1006-1959.2021.24.007]
　LI Qing-he,LIAO Ling-ling,WANG Hong-yan.Analysis of Influencing Factors of Coagulation Indexes on Prognosis of Esophageal Squamous Cell Carcinoma[J].Medical Information,2021,34(24):33-38.[doi:10.3969/j.issn.1006-1959.2021.24.007]
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凝血指标对食管鳞癌预后的影响因素分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年24期
页码:
33-38
栏目:
论著
出版日期:
2021-12-15

文章信息/Info

Title:
Analysis of Influencing Factors of Coagulation Indexes on Prognosis of Esophageal Squamous Cell Carcinoma
文章编号:
1006-1959（2021）24-0033-06
作者:
李清河; 廖玲玲; 汪红艳
（安徽医科大学第一附属医院肿瘤放疗科，安徽 合肥 230000）
Author(s):
LI Qing-he; LIAO Ling-ling; WANG Hong-yan
(Department of Oncology and Radiotherapy,the First Affiliated Hospital of Anhui Medical University,Hefei 230000,Anhui,China)
关键词:
食管鳞癌; D-二聚体; 纤维蛋白原; 凝血指标
Keywords:
Esophageal squamous cell carcinoma; D-dimer; Fibrinogen; Coagulation indicators
分类号:
R735.1
DOI:
10.3969/j.issn.1006-1959.2021.24.007
文献标志码:
A
摘要:
目的 探讨凝血指标和食管鳞癌患者预后之间的关系。方法 从病例系统收集2015年12月1日-2019年7月1日在我院治疗的食管鳞癌患者140例，并收集同期在我院体检的健康人103名，比较两组受试者凝血指标，分析食管鳞癌组凝血指标与临床资料的关系，食管鳞癌患者不同年龄（≤70岁组，＞70岁组）、性别（男性，女性）、TNM分期（非晚期组，晚期组）以及不同病灶长度（＜5 cm组，≥5 cm组）的凝血指标；并进行生存分析，分析食管鳞癌患者预后的独立危险因素。结果 食管鳞癌患者PT、PT-INR、APTT较健康人缩短，PT-%、FIB、TT、D-D较健康人水平高，差异有统计学意义（P＜0.05）；不同年龄、性别、TNM分期及病灶长度PT、PT-%、PT-INR、APTT、TT比较，差异无统计学意义（P＞0.05）；晚期组的FIB、D-D水平高于非晚期组，差异有统计学意义（P＜0.05）；病灶长度＜5 cm组FIB水平低于病灶≥5 cm组，差异有统计学意义（P＜0.05）；单因素分析显示，TNM分期、纤维蛋白原、D-二聚体与食管鳞癌患者无进展生存期缩短存在相关性（P＜0.05）；TNM分期、凝血酶原时间活动度、D-二聚体、纤维蛋白原与食管鳞癌患者总生存时间缩短存在相关性（P＜0.05）；COX多因素分析结果显示，纤维蛋白原（HR=1.269，95%CI=1.043~1.544，P＜0.05）和TNM分期（HR=1.803，95%CI=1.143~2.842，P＜0.05）是无进展生存期的独立预后因素：TNM分期（HR=2.12，95%CI=1.331~3.377，P＜0.05），D-二聚体（HR=1.095，95%CI=1.01~1.187，P＜0.05）和FIB水平（HR=1.294，95%CI=1.058~1.583，P＜0.05）是总生存期的独立预后因素。结论 高水平的纤维蛋白原与食管鳞癌患者的不良预后之间存在相关性，纤维蛋白原可作为预测食管鳞癌预后的独立危险因素。
Abstract:
Objective To investigate the relationship between coagulation indexes and prognosis of patients with esophageal squamous cell carcinoma.Methods A total of 140 patients with esophageal squamous cell carcinoma treated in our hospital from December 1,2015 to July 1,2019 were collected from the case system, and 103 healthy people who underwent physical examination in our hospital at the same time were collected. The coagulation indexes of the two groups were compared. The relationship between coagulation indexes and clinical data in esophageal squamous cell carcinoma group was analyzed. The coagulation indexes of esophageal squamous cell carcinoma patients with different ages (≤70 years old group, >70 years old group ), gender (male, female), TNM stage (non-advanced group, advanced group) and different lesion lengths (<5 cm group, ≥5 cm group) were analyzed. Survival analysis was performed to analyze the independent risk factors of prognosis in patients with esophageal squamous cell carcinoma.Results PT, PT-INR and APTT in patients with esophageal squamous cell carcinoma were shorter than those in healthy people, PT-%, FIB, TT and D-D were higher than those in healthy people, and the difference was statistically significant (P<0.05). There were no significant differences in PT, PT-%, PT-INR, APTT and TT among different age, gender, TNM stage and lesion length (P>0.05). The levels of FIB and D-D in the advanced group were higher than those in the non-advanced group, and the difference was statistically significant (P<0.05). The level of FIB in the lesion length <5 cm group was lower than that in the lesion length ≥5 cm group, and the difference was statistically significant (P<0.05). Univariate analysis showed that TNM staging, fibrinogen and D-dimer were correlated with the shortening of progression-free survival (P<0.05); TNM stage, prothrombin time activity, D-dimer and fibrinogen were correlated with the shortening of total survival time in patients with esophageal squamous cell carcinoma (P<0.05). COX multivariate analysis showed that fibrinogen (HR=1.269, 95%CI=1.043-1.544,P<0.05) and TNM stage (HR=1.803, 95%CI=1.143-2.842, P<0.05 ) were independent prognostic factors for progression-free survival; TNM stage (HR=2.12, 95%CI=1.331-3.377, P<0.05), D-dimer (HR=1.095, 95%CI=1.01-1.187,P<0.05) and FIB (HR=1.294, 95%CI=1.058-1.583,P<0.05) were independent prognostic factors for overall survival.Conclusion There is a correlation between high level of fibrinogen and poor prognosis in patients with esophageal squamous cell carcinoma, fibrinogen can be used as an independent risk factor for predicting the prognosis of esophageal squamous cell carcinoma.

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更新日期/Last Update: 1900-01-01