[1]吴忠军,林 涛,胡 彬.兰索拉唑、奥曲肽、凝血酶三联治疗重症上消化道出血的临床疗效及并发症观察[J].医学信息,2021,(24):64-67.[doi:10.3969/j.issn.1006-1959.2021.24.013]
 WU Zhong-jun,LIN Tao,HU Bin.Clinical Effects and Complications of Lansoprazole, Octreotide and Thrombin in the Treatment of Severe Upper Gastrointestinal Hemorrhage[J].Medical Information,2021,(24):64-67.[doi:10.3969/j.issn.1006-1959.2021.24.013]
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兰索拉唑、奥曲肽、凝血酶三联治疗重症上消化道出血的临床疗效及并发症观察()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2021年24期
页码:
64-67
栏目:
论著
出版日期:
2021-12-15

文章信息/Info

Title:
Clinical Effects and Complications of Lansoprazole, Octreotide and Thrombin in the Treatment of Severe Upper Gastrointestinal Hemorrhage
文章编号:
1006-1959(2021)24-0064-04
作者:
吴忠军林 涛胡 彬
(上饶市广信区中医院重症ICU,江西 上饶 334100)
Author(s):
WU Zhong-junLIN TaoHU Bin
(Intensive ICU,Shangrao Guangxin District Hospital of Traditional Chinese Medicine,Shangrao 334100,Jiangxi,China)
关键词:
上消化道出血胃泌素兰索拉唑凝血酶奥曲肽炎性反应
Keywords:
Upper gastrointestinal hemorrhageGastrinLansoprazoleThrombinOctreotideInflammatory reaction
分类号:
R573.2
DOI:
10.3969/j.issn.1006-1959.2021.24.013
文献标志码:
A
摘要:
目的 观察兰索拉唑、奥曲肽、凝血酶三联治疗重症上消化道出血的临床疗效及并发症情况。方法 选取2018年2月-2021年6月我院收治的60例重症上消化道出血患者,按照随机数字表法分为对照组与观察组,各30例。对照组应用兰索拉唑联合凝血酶治疗,观察组应用兰索拉唑、奥曲肽、凝血酶三联治疗,比较两组止血疗效、止血时间、输血量、再出血率、炎性应激指标[超敏-C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、皮质醇(COR)]、胃液pH值、血清胃泌素水平、全血血红蛋白水平、并发症发生情况。结果 观察组止血总有效率为96.67%,高于对照组的80.00%,差异有统计学意义(P<0.05);观察组止血时间短于对照组,输血量、再出血率小于对照组,差异有统计学意义(P<0.05);观察组hs-CRP、TNF-α、COR水平低于对照组,差异有统计学意义(P<0.05);观察组胃液pH值、血红蛋白高于对照组,胃泌素水平低于对照组,差异有统计学意义(P<0.05);两组并发症总发生率比较,差异无统计学意义(P>0.05)。结论 兰索拉唑、奥曲肽、凝血酶三联治疗重症上消化道出血疗效肯定,可缩短患者止血时间,减少输血量及再出血风险,缓解机体炎性应激反应,同时改善其胃液pH值及胃泌素、血红蛋白指标,且不增加并发症发生风险。
Abstract:
Objective To observe the clinical efficacy and complications of lansoprazole, octreotide and thrombin in the treatment of severe upper gastrointestinal hemorrhage.Methods Sixty patients with severe upper gastrointestinal hemorrhage admitted to our hospital from February 2018 to June 2021 were selected and randomly divided into the control group and the observation group, with 30 cases in each group. The control group was treated with lansoprazole combined with thrombin, and the observation group was treated with lansoprazole, octreotide and thrombin. The hemostatic efficacy, hemostatic time, blood transfusion volume, rebleeding rate, inflammatory stress indexes [high sensitivity-C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), cortisol (COR)], gastric pH value, serum gastrin level, whole blood hemoglobin level, and complications were compared between the two groups.Results The total effective rate of hemostasis in the observation group was 96.67%, which was higher than 80.00% in the control group, and the difference was statistically significant (P<0.05). The hemostasis time of the observation group was shorter than that of the control group, and the amount of blood transfusion and rebleeding rate were less than those of the control group, the difference was statistically significant (P<0.05). The levels of hs-CRP, TNF-α and COR in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The gastric juice pH value and hemoglobin in the observation group were higher than those in the control group, and the gastrin level was lower than that in the control group, the difference was statistically significant (P<0.05). There was no significant difference in the total incidence of complications between the two groups (P>0.05).Conclusion The triple combination of lansoprazole, octreotide and thrombin has a positive effect in the treatment of severe upper gastrointestinal hemorrhage, which can shorten the time of hemostasis, reduce the amount of blood transfusion and the risk of rebleeding, alleviate the body’s inflammatory stress response, and improve the gastric juice pH value, gastrin and hemoglobin indicators, and do not increase the risk of complications.

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更新日期/Last Update: 1900-01-01