[1]李 颖,张再伟.miRNA在急性心肌梗死早期诊断中的作用及其机制研究[J].医学信息,2022,35(05):40-43.[doi:10.3969/j.issn.1006-1959.2022.05.010]
 LI Ying,ZHANG Zai-wei.The Role and Mechanism of miRNA in Early Diagnosis of Acute Myocardial Infarction[J].Medical Information,2022,35(05):40-43.[doi:10.3969/j.issn.1006-1959.2022.05.010]
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miRNA在急性心肌梗死早期诊断中的作用及其机制研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年05期
页码:
40-43
栏目:
综述
出版日期:
2022-03-01

文章信息/Info

Title:
The Role and Mechanism of miRNA in Early Diagnosis of Acute Myocardial Infarction
文章编号:
1006-1959(2022)05-0040-04
作者:
李 颖张再伟
(1.济宁医学院临床医学院,山东 济宁 272000;2.济宁市第一人民医院心内科,山东 济宁 272002;3.济宁市第一人民医院心血管病研究所,山东 济宁 272002)
Author(s):
LI YingZHANG Zai-wei
(1.Clinical Medical College,Jining Medical University,Jining 272000,Shandong,China;2.Department of Cardiology,Jining No.1 People’s Hospital,Jining 272002,Shandong,China;3.Cardiovascular Research Institute,Jining No.1 People’s Hospital,Jining 272002,Shandong,China)
关键词:
miRNA急性心肌梗死早期诊断炎症反应新生血管形成纤维化
Keywords:
microRNAAcute myocardial infarctionEarly diagnosisInflammatory responseNeovascularizationFibrosis
分类号:
R542.22
DOI:
10.3969/j.issn.1006-1959.2022.05.010
文献标志码:
A
摘要:
近年来,急性心肌梗死(AMI)在全球范围内的发病率逐年增加,已成为严重威胁人类健康的疾病之一。虽然临床上已有完善的AMI诊断及治疗方法,且已极大程度的挽救了患者的生命,但全球范围内AMI的发病率和死亡率仍不断上升,因此亟需寻找早期可检测该病的,无创、高灵敏度、高特异性的生物标志物。研究认为,微小RNA(microRNA)在转录后水平调节基因表达,在细胞的生理病理过程中发挥重要作用,其有可能成为诊断及治疗AMI的新的生物标志物。为此,本文主要综述miRNA在AMI的早期诊断及发生炎症反应、新生血管形成和纤维化等方面的部分作用及机制,以期为临床早期诊治AMI提供帮助。
Abstract:
In recent years, the incidence of acute myocardial infarction (AMI) has increased year by year worldwide, and it has become one of the diseases that seriously threaten human health. Although the clinical diagnosis and treatment of AMI have been improved, and the patient’s life has been saved to a great extent, the incidence and mortality of AMI are still rising worldwide. Therefore, it is urgent to find early, noninvasive, highly sensitive and highly specific biomarkers for the disease. Studies have shown that microRNAs regulate gene expression at the post-transcriptional level and play an important role in the physiological and pathological process of cells, which may become a new biomarker for the diagnosis and treatment of AMI. Therefore, this paper mainly reviews the role and mechanism of miRNA in the early diagnosis of AMI and the occurrence of inflammatory reactions, angiogenesis and fibrosis, so as to provide help for the early diagnosis and treatment of AMI in clinic.

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更新日期/Last Update: 1900-01-01