[1]贾鹏飞,崔海燕,胡宝荣.中性粒细胞与淋巴细胞和血小板乘积的比值对重症肺炎患者短期生存状态的预测价值[J].医学信息,2022,35(15):79-82.[doi:10.3969/j.issn.1006-1959.2022.15.017]
　JIA Peng-fei,CUI Hai-yan,HU Bao-rong.The Predictive Value of Neutrophil to Lymphocyte and Platelet Ratio for Short-term Survival in Patients with Severe Pneumonia[J].Journal of Medical Information,2022,35(15):79-82.[doi:10.3969/j.issn.1006-1959.2022.15.017]
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中性粒细胞与淋巴细胞和血小板乘积的比值对重症肺炎患者短期生存状态的预测价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年15期
页码:
79-82
栏目:
论著
出版日期:
2022-08-01

文章信息/Info

Title:
The Predictive Value of Neutrophil to Lymphocyte and Platelet Ratio for Short-term Survival in Patients with Severe Pneumonia
文章编号:
1006-1959（2022）15-0079-04
作者:
贾鹏飞; 崔海燕; 胡宝荣
（陇南市武都区第一人民医院重症医学科，甘肃 陇南 746000）
Author(s):
JIA Peng-fei; CUI Hai-yan; HU Bao-rong
(Department of Intensive Care Unit,the First People’s Hospital of Wudu District,Longnan 746000,Gansu,China)
关键词:
重症肺炎; 中性粒细胞; 淋巴细胞; 血小板; 生存状态
Keywords:
Serve pneumonia; Neutrophil; Lymphocytes; Platelet; Survival state
分类号:
R563.1
DOI:
10.3969/j.issn.1006-1959.2022.15.017
文献标志码:
A
摘要:
目的 评估重症肺炎患者中性粒细胞计数与淋巴细胞和血小板乘积的比值对其短期生存状态的预测价值。方法 回顾性分析我院2018年1月-2021年1月271例重症肺炎患者的临床资料，依据28 d后的生存状态分为死亡组（191例）和存活组（80例），采用倾向评分匹配法（PSM）减少两组一般资料的差异，比较PSM后两组入院3 d内的中性粒细胞计数（NEU）、淋巴细胞计数（LYM）、血小板计数（PLT）、NEU与LYM比值（NLR）和NEU与LYM和PLT乘积的比值（NLPR），采用ROC曲线分析NLR和NLPR对重症肺炎28 d后生存状态预测的最佳截断值，分析NLPR对重症肺炎患者术28 d生存状态的预测价值。结果 PSM后两组性别、COPD、高血压、心力衰竭、冠心病、吸烟、脑梗死及胸部手术史比较，差异无统计学意义（P＞0.05）；死亡组WBC、NEU、NLR和NLPR高于存活组，LYM和PLT低于存活组，差异有统计学意义（P＜0.05）；ROC曲线显示，NLR对重症肺炎患者28 d后的生存状态预测的曲线下面积（AUC）为0.808，约登指数为6.410；NLPR对重症肺炎患者28 d后的生存状态预测的AUC为0.916，约登指数为8.050；NLR≥6.41的重症肺炎患者28 d病死率高于NLR＜6.41的患者，NLPR≥8.05的重症肺炎患者28 d病死率高于NLPR＜8.05的患者，差异均有统计学意义（P＜0.05）。结论 重症肺炎死亡患者的NLPR水平高于存活患者，NLPR对重症肺炎患者28 d的生存状态有一定的预测价值。
Abstract:
Objective To evaluate the predictive value of neutrophil to lymphocyte and platelet ratio for short-term survival in patients with severe pneumonia.Methods The clinical data of 271 patients with severe pneumonia in our hospital from January 2018 to January 2021 were retrospectively analyzed. According to the survival status after 28 days, they were divided into death group (191 cases) and survival group (80 cases). The propensity score matching (PSM) was used to reduce the difference in general data between the two groups. The neutrophil count (NEU), lymphocyte count (LYM), platelet count (PLT), NEU/LYM ratio (NLR) and NEU/LYM/PLT product ratio (NLPR) were compared between the two groups within 3 days of admission after PSM. ROC curve was used to analyze the optimal cut-off value of NLR and NLPR for predicting the survival status of patients with severe pneumonia after 28-day of operation. The predictive value of NLPR for the survival status of patients with severe pneumonia after 28 days of operation was analyzed.Results There was no significant difference in gender, COPD, hypertension, heart failure, coronary heart disease, smoking, cerebral infarction and chest operation history between the two groups after PSM (P>0.05). WBC, NEU, NLR and NLPR in the death group were higher than those in the survival group, LYM and PLT were lower than those in the survival group, and the difference was statistically significant (P<0.05). ROC curve showed that the area under the curve (AUC) of NLR for predicting the survival status of patients with severe pneumonia after 28 d was 0.808, and the Joden index was 6.410; the AUC of NLPR for predicting the survival status of patients with severe pneumonia after 28 d was 0.916, and the Yordon index was 8.050; the 28-day mortality rate of severe pneumonia patients with NLR≥6.41 was higher than that of patients with NLR<6.41, and the 28-day mortality rate of severe pneumonia patients with NLPR≥8.05 was higher than that of patients with NLPR<8.05, and the differences were statistically significant (P<0.05).Conclusion The NLPR level of death patients with severe pneumonia is higher than that of survival patients, and NLPR has certain predictive value for 28-day survival status of patients with severe pneumonia.

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更新日期/Last Update: 1900-01-01