[1]汪 琴,方长太,陈园园.N/LP对脓毒症AKI患者预后的评估价值及其与罗氏AKI评分的相关性[J].医学信息,2021,34(19):113-115,119.[doi:10.3969/j.issn.1006-1959.2021.19.029]
　WANG Qin,FANG Chang-tai,CHEN Yuan-yuan.Prognostic Value of N/LP in Septic AKI Patients and its Correlation with Roche AKI Score[J].Medical Information,2021,34(19):113-115,119.[doi:10.3969/j.issn.1006-1959.2021.19.029]
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N/LP对脓毒症AKI患者预后的评估价值及其与罗氏AKI评分的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年19期
页码:
113-115,119
栏目:
论著
出版日期:
2021-10-01

文章信息/Info

Title:
Prognostic Value of N/LP in Septic AKI Patients and its Correlation with Roche AKI Score
文章编号:
1006-1959（2021）19-0113-04
作者:
汪 琴; 方长太; 陈园园
安徽医科大学附属安庆医院重症医学科，安徽 安庆 246000
Author(s):
WANG Qin; FANG Chang-tai; CHEN Yuan-yuan
Intensive Care Unit,Anqing Hospital Affiliated to Anhui Medical University,Anqing 246000,Anhui,China
关键词:
中性粒细胞; 淋巴细胞; 血小板; 脓毒症; 急性肾损伤; 罗氏AKI评分
Keywords:
Neutrophils; Lymphocytes; Platelets; Sepsis; Acute kidney injury; Roche AKI score
分类号:
R692
DOI:
10.3969/j.issn.1006-1959.2021.19.029
文献标志码:
A
摘要:
目的 探讨中性粒细胞与淋巴细胞和血小板比值（N/LP）评估脓毒症急性肾损伤（AKI）患者预后的价值，分析其与罗氏AKI评分的相关性。方法 回顾性分析安徽医科大学附属安庆医院重症医学科2017年1月-2020年 5月住院的脓毒症并发AKI患者137例，根据患者预后分为存活组（51例）和死亡组（86例），比较两组入院24 h内中性粒细胞计数、淋巴细胞计数、血小板计数、N/LP比值、序贯器官功能衰竭（SOFA）评分及罗氏AKI评分，评价N/LP评估脓毒症AKI患者预后的价值，分析其与罗氏AKI评分的相关性。结果 两组性别及SOFA评分比较，差异无统计学意义（P＞0.05）；死亡组年龄、入院24 h内N/LP、罗氏AKI评分高于存活组，差异有统计学意义（P＜0.05）；Spearman 相关分析显示，N/LP与罗氏AKI评分呈正相关性（r=0.342，P=0.000）；N/LP诊断脓毒症AKI患者的AUC为0.619（95%CI：0.522~0.716），敏感度为65.10%，特异度为58.80%，截断值为16.14%；罗氏AKI评分诊断脓毒症AKI患者的AUC为0.647（95%CI：0.551~0.744），敏感度为69.80%，特异度为60.80%，截断值为9.50分；N/LP联合罗氏AKI评分诊断脓毒症AKI患者的AUC为0.655（95%CI：0.559~0.751），敏感度为77.90%，特异度为52.90%。结论 患者入院24 h内N/LP与罗氏AKI评分呈正相关，且N/LP联合罗氏AKI评分可用于脓毒症AKI患者预后的评估。
Abstract:
Objective To investigate the prognostic value of neutrophil/lymphocyte and platelet ratio(N/LP) in patients with septic acute kidney injury(AKI), and to analyze its relationship with the Roche AKI score correlation.Methods A retrospective analysis method was used to select 137 patients with septic AKI who were hospitalized in the Intensive Care Unit of Anqing Hospital Affiliated to Anhui Medical University from January 2017 to May 2020. According to the prognosis of patients, they were divided into the survival group (n=51) and the death group (n=86), the neutrophil count, lymphocyte count, platelet count, N/LP ratio, sequential organ failure (SOFA) score and Roche AKI score were compared between the two groups within 24 h after admission, the value of N/LP in evaluating the prognosis of patients with septic AKI was evaluated, and its correlation with Roche AKI score was analyzed.Results There was no statistically significant difference in gender and SOFA score between the two groups (P>0.05). The age, N/LP and Roche AKI scores within 24 h after admission in the death group were higher than those in the survival group, and the differences were statistically significant (P<0.05 ). Spearman correlation analysis showed that N/LP was positively correlated with Roche AKI score (r=0.342, P=0.000). The area under AUC curve of N/LP in patients with sepsis AKI was 0.619 (95%CI:0.522-0.716), the sensitivity was 65.10%, the specificity was 58.80%, and the cut-off value was 16.14%. The area under AUC curve of patients with sepsis AKI diagnosed by Roche AKI score was 0.647 (95%CI:0.551-0.744), the sensitivity was 69.80%, the specificity was 60.80%, and the cutoff value was 9.50. The area under AUC curve of N/LP combined with Roche AKI score in the diagnosis of sepsis AKI patients was 0.655(95%CI:0.559-0.751), the sensitivity was 77.90%, and the specificity was 52.90 %.Conclusion The ratio of neutrophils to lymphocytes and platelets within 24 h after admission are positively correlated with Roche AKI score, and N/LP combined with Roche AKI score could be used to evaluate the prognosis of patients with septic AKI.

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更新日期/Last Update: 1900-01-01