[1]吴碧兰,孔秀莲,朱云中,等.基于网络药理学探讨桃红大将逐瘀汤加减治疗便秘的作用机制[J].医学信息,2023,36(09):30-34.[doi:10.3969/j.issn.1006-1959.2023.09.005]
　WU Bi-lan,KONG Xiu-lian,ZHU Yun-zhong,et al.Mechanism of Modified Taohong Dajiang Zhuyu Decoction in the Treatment of Constipation Based on Network Pharmacology[J].Journal of Medical Information,2023,36(09):30-34.[doi:10.3969/j.issn.1006-1959.2023.09.005]
点击复制

基于网络药理学探讨桃红大将逐瘀汤加减治疗便秘的作用机制()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年09期
页码:
30-34
栏目:
中医药信息学
出版日期:
2023-05-01

文章信息/Info

Title:
Mechanism of Modified Taohong Dajiang Zhuyu Decoction in the Treatment of Constipation Based on Network Pharmacology
文章编号:
1006-1959（2023）09-0030-05
作者:
吴碧兰; 孔秀莲; 朱云中; 等
（广西中医药大学第一附属医院神经外科，广西 南宁 530023）
Author(s):
WU Bi-lan; KONG Xiu-lian; ZHU Yun-zhong; et al.
(Department of Neurosurgery,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi,China)
关键词:
便秘; 桃红大将逐瘀汤; 信号通路; 活性化合物
Keywords:
Constipation; Taohong Dajiang Zhuyu decoction; Signal pathway; Active compounds
分类号:
R256.35
DOI:
10.3969/j.issn.1006-1959.2023.09.005
文献标志码:
A
摘要:
目的 基于网络药理学探讨桃红大将逐瘀汤加减治疗便秘的作用机制。方法 采用TCMSP数据库检索和筛选桃红大将逐瘀汤加减的中药活性化合物及其靶点；运用GeneGards和OMIM数据库筛选出与便秘相关的基因，将其与药物靶点交集获得靶基因并构建活性化合物-靶基因网络。利用String数据库构建靶基因的PPI网络，并筛选出关键基因；再对靶基因进行GO和KEGG富集分析。结果 桃红大将逐瘀汤加减有82个活性化合物作用于227个基因，与疾病相关的基因有4663个，通过交集得到177靶基因；其中ALB、AKT1、IL6、JUN、CASP3、VEGFA、IL1B、EGFR、PTGS2、MYC等10个基因是关键基因，主要富集在169个GO条目以及IL-17信号通路、TNF信号通路等158个KEGG通路中。结论 桃红大将逐瘀汤加减主要通过ALB、AKT1、IL6等基因及IL-17信号通路和TNF信号通路调节肠道蠕动功能，达到治疗便秘目的。
Abstract:
Objective To investigation the mechanism of modified Taohong Dajiang Zhuyu decoction in the treatment of constipation based on network pharmacology.Methods TCMSP database was used to search and screen the active compound and target of modified Taohong Dajiang Zhuyu decoction. Genes related to constipation were screened by GeneGards and OMIM database, and target genes were obtained by intersection with drug targets, and active compound target gene network was constructed. PPI network of target genes was constructed using String database, and key genes were selected out. GO and KEGG enrichment analysis was done for target genes.Results There were 82 active compounds acting on 227 genes, 4663 genes related to disease, 177 target genes were delivered by intersection. Ten genes including ALB, AKT1, IL6, JUN, CASP3, VEGFA, IL1B, EGFR, PTGS2 and MYC were key genes, which were mainly enriched in 169 GO items and 158 KEGG pathways including IL-17 signaling pathway and TNF signaling pathway.Conclusion Modified Taohong Dajiang Zhuyu decoction mainly regulates intestinal peristalsis through ALB, AKT1, IL6 and OTHER genes as well as IL-17 signaling pathway and TNF signaling pathway, thus achieving the objective of treating constipation.

参考文献/References:

[1]许秀芬,李金萍,杨敏,等.中西药合用治疗老年慢性便秘临床观察[J].实用中医药杂志,2020,36(7):879-880.[2]Naseer M,Poola S,Uraz S,et al.Therapeutic Effects of Prebiotics on Constipation: A Schematic Review[J].Curr Clin Pharmacol,2020,15(3):207-215.[3]Zhu L,Ma Y,Deng X.Comparison of acupuncture and other drugs for chronic constipation: A network meta-analysis[J].PLoS One,2018,13(4):e0196128.[4]林琳,陈颖.慢性便秘治疗药物临床试验设计和评价考虑要点[J].中国临床药理学杂志,2022,38(11):1287-1292.[5]钟远鸣,李智斐,许建文,等.桃红大将逐瘀汤对急性腰痛症疼痛缓解及便秘预防的疗效观察[J].广西中医学院学报,2009,12(1):3-5.[6]黎启福,黄志锋,冼海庭,等.桃红大将逐瘀汤加减方治疗胸腰椎骨折早期并发症73例[J].实用中医药杂志,2018,34(6):664-665.[7]陈萌,于永铎,张斯瑶,等.化瘀通便汤对慢传输型便秘大鼠结肠Cajal间质细胞及相关蛋白表达调节作用的实验研究[J].时珍国医国药,2022,33(5):1056-1059.[8]陈霞,温伟波,张鹏.理气导滞法对慢传输型便秘小鼠结肠动力的促进作用[J].中成药,2019,41(7):1717-1720.[9]王亮,王鹏达,齐玉珍,等.健脾通便汤治疗慢传输型便秘的临床观察[J].宁夏医学杂志,2019,41(12):1095-1097.[10]Kim JE,Lee MR,Park JJ,et al.Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal[J].Pharm Biol,2018,56(1):309-317. [11]卞艺斐.马齿苋对实验性肠炎大鼠的保护作用及其机制研究[D].北京:中国农业大学,2018.[12]Rakariyatham K,Wu X,Tang Z,et al.Synergism between luteolin and sulforaphane in anti-inflammation[J].Food Funct,2018,9(10):5115-5123. [13]张喻然,王波.济川煎加味联合腹针对慢传输型便秘(脾肾阳虚型)疗效及对血清SP和NO水平的干预影响[J].中国中西医结合消化杂志,2018,26(3):238-242．[14]Bteich M,Poulin P,Haddad S.The potential protein-mediated hepatic uptake: discussion on the molecular interactions between albumin and the hepatocyte cell surface and their implications for the in vitro-to-in vivo extrapolations of hepatic clearance of drugs[J].Expert Opin Drug Metab Toxicol,2019,15(8):633-658. [15]Liang Y,Wang Y,Wen P,et al.The Anti-Constipation Effects of Raffino-Oligosaccharide on Gut Function in Mice Using Neurotransmitter Analyses, 16S rRNA Sequencing and Targeted Screening[J].Molecules,2022,27(7):2235. [16]Chen R,Yin W,Gao H,et al.The effects of early enteral nutrition on the nutritional statuses, gastrointestinal functions, and inflammatory responses of gastrointestinal tumor patients[J].Am J Transl Res,2021,13(6):6260-6269. [17]Manning BD,Toker A.AKT/PKB Signaling: Navigating the Network[J].Cell,2017,169(3):381-405.[18]Cole PA,Chu N,Salguero AL,et al.AKTivation mechanisms[J].Curr Opin Struct Biol,2019,59:47-53. [19]Zhou J,Peng Y,Gao YC,et al.Targeting DNAJC19 overcomes tumor growth and lung metastasis in NSCLC by regulating PI3K/AKT signaling[J].Cancer Cell Int,2021,21(1):338. [20]Chen Y,Huang L,Dong Y,et al.Effect of AKT1 (p. E17K) Hotspot Mutation on Malignant Tumorigenesis and Prognosis[J].Front Cell Dev Biol,2020,8:573599. [21]梁红宝,李蕊,姚景春,等.基于网络药理学和分子对接方法研究首荟通便胶囊治疗便秘的作用机制[J].中国中药杂志,2021,46(3):511-519.[22]范文涛,王攀红,王倩.马齿苋多糖对溃疡性结肠炎大鼠肠组织IL-6/STAT3及NF-κB的影响[J].中国应用生理学杂志,2018,34(3):263-267.

相似文献/References:

[1]夏友光,令狐庆.运脾化湿法治疗脾虚气滞型便秘的临床疗效观察[J].医学信息,2018,31(21):158.[doi:10.3969/j.issn.1006-1959.2018.21.046]
　XIA You-guang,LINHU Qing.Clinical Observation on the Treatment of Constipation with Spleen Deficiency and Qi Stagnation Type by Removing Spleen and Removing Dampness[J].Journal of Medical Information,2018,31(09):158.[doi:10.3969/j.issn.1006-1959.2018.21.046]
[2]付满玲,庞 艳,杨树娟,等.肠通对小鼠便秘的有效性研究[J].医学信息,2019,32(09):74.[doi:10.3969/j.issn.1006-1959.2019.09.024]
　FU Man-ling,PANG Yan,YANG Shu-juan,et al.Effect of Changtong on Constipation in Mice[J].Journal of Medical Information,2019,32(09):74.[doi:10.3969/j.issn.1006-1959.2019.09.024]
[3]朱 婷,曹永一,李玉芝,等.中药脐疗袋治疗阿片类药物相关性便秘的疗效[J].医学信息,2020,33(10):167.[doi:10.3969/j.issn.1006-1959.2020.10.051]
　ZHU Ting,CAO Yong-yi,LI Yu-zhi,et al.Therapeutic Effect of Traditional Chinese Medicine Umbilical Therapy Bag on Opioid-related Constipation[J].Journal of Medical Information,2020,33(09):167.[doi:10.3969/j.issn.1006-1959.2020.10.051]
[4]苏 晶,丁 劲,葸英博,等.天枢穴穴位贴敷治疗骨科患者卧床相关便秘疗效的Meta分析[J].医学信息,2021,34(18):106.[doi:10.3969/j.issn.1006-1959.2021.18.027]
　SU Jing,DING Jin,XI Ying-bo,et al.Meta-analysis of Therapeutic Effects of Tianshu Acupoint Application on Orthopedic Patientswith Bed-related Constipation[J].Journal of Medical Information,2021,34(09):106.[doi:10.3969/j.issn.1006-1959.2021.18.027]
[5]杨丽红,杨雪芳,屠冬英,等.慢性便秘患者结肠镜检查肠道准备的文献计量学分析[J].医学信息,2021,34(20):20.[doi:10.3969/j.issn.1006-1959.2021.20.005]
　YANG Li-hong,YANG Xue-fang,TU Dong-ying,et al.Bibliometric Analysis of Bowel Preparations for Colonoscopy in Patients with Chronic Constipation[J].Journal of Medical Information,2021,34(09):20.[doi:10.3969/j.issn.1006-1959.2021.20.005]
[6]王艳霞.中药灌肠对尿毒症血液透析患者便秘、食欲减退及呕吐等不良反应的影响[J].医学信息,2022,35(17):88.[doi:10.3969/j.issn.1006-1959.2022.17.023]
　WANG Yan-xia.Effect of Traditional Chinese Herb Enema on Adverse Reactions of Constipation,Loss of Appetite and Vomiting in Uremic Hemodialysis Patients[J].Journal of Medical Information,2022,35(09):88.[doi:10.3969/j.issn.1006-1959.2022.17.023]
[7]丁葵花,潘龙娥.健康教育路径在择期剖宫产护理质量中的应用[J].医学信息,2022,35(19):183.[doi:10.3969/j.issn.1006-1959.2022.19.052]
　DING Kui-hua,PAN Long-e.Application of Health Education Pathway in Nursing Quality of Elective Cesarean Section[J].Journal of Medical Information,2022,35(09):183.[doi:10.3969/j.issn.1006-1959.2022.19.052]
[8]严 莲,黄 卫,宋玲毅,等.中药贴敷在胸腰椎术后腹胀及便秘应用研究的Meta分析[J].医学信息,2022,35(21):34.[doi:10.3969/j.issn.1006-1959.2022.21.007]
　YAN Lian,HUANG Wei,SONG Ling-yi,et al.Meta Analysis of Application of Chinese Herbal Paste in Abdominal Distension and Constipation After Thoracolumbar Surgery[J].Journal of Medical Information,2022,35(09):34.[doi:10.3969/j.issn.1006-1959.2022.21.007]

更新日期/Last Update: 1900-01-01