[1]全 红,唐玉娟,王 然.血清TNF-α、CRP、IL-6指标在慢性肾功能衰竭患者中的检验价值分析[J].医学信息,2023,36(09):128-130,134.[doi:10.3969/j.issn.1006-1959.2023.09.026]
　QUAN Hong,TANG Yu-juan,WANG Ran.Analysis of the Test Value of Serum TNF-α,CRP and IL-6 in Patients with Chronic Renal Failure[J].Journal of Medical Information,2023,36(09):128-130,134.[doi:10.3969/j.issn.1006-1959.2023.09.026]
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血清TNF-α、CRP、IL-6指标在慢性肾功能衰竭患者中的检验价值分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年09期
页码:
128-130,134
栏目:
论著
出版日期:
2023-05-01

文章信息/Info

Title:
Analysis of the Test Value of Serum TNF-α,CRP and IL-6 in Patients with Chronic Renal Failure
文章编号:
1006-1959（2023）09-0128-04
作者:
全 红; 唐玉娟; 王 然
（佳木斯市中心医院检验科，黑龙江 佳木斯 154002）
Author(s):
QUAN Hong; TANG Yu-juan; WANG Ran
(Department of Laboratory,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
瘤坏死因子-α; C反应蛋白; 白细胞介素-6; 慢性肾功能衰竭; 血液透析
Keywords:
Tumor necrosis factor-α; C-reactive protein; Interleukin-6; Chronic renal failure; Hemodialysis
分类号:
R692.5
DOI:
10.3969/j.issn.1006-1959.2023.09.026
文献标志码:
A
摘要:
目的 分析血清瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）、白细胞介素-6（IL-6）在慢性肾功能衰竭（CRF）患者中的检验价值。方法 将2019年2月-2022年2月佳木斯市中心医院收治的80例CRF患者设为CRF组，其肾功能衰竭分期为：Ⅰ期12例、Ⅱ期24例，Ⅲ期25例，Ⅳ期19例。另选取同期80位健康体检者设为健康组，检测两组血清TNF-α、CRP、IL-6指标，比较CRF组与健康组、不同分期CRF患者、血液透析治疗前后CRF患者的血清TNF-α、CRP、IL-6水平。结果 CRF组血清TNF-α、CRP、IL-6指标水平高于健康组（P＜0.05）；CRF患者不同分期血清TNF-α、CRP、IL-6指标由高至低依次为Ⅳ期＞Ⅲ期＞Ⅱ期＞Ⅰ期（P＜0.05）；CRF组血液透析后的血清TNF-α、CRP、IL-6指标低于血液透析前（P＜0.05）。结论 血清TNF-α、CRP、IL-6指标在CRF患者中呈高表达，其含量水平随疾病分期进展而增加，经血液透析后下降。
Abstract:
Objective To analyze the test value of serum tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and interleukin-6 (IL-6) in patients with chronic renal failure (CRF).Methods A total of 80 CRF patients admitted to Jiamusi Central Hospital from February 2019 to February 2022 were set as CRF group, and their renal failure stages were: 12 cases of stageⅠ, 24 cases of stage Ⅱ, 25 cases of stage Ⅲ, 19 cases of stage Ⅳ. Another 80 healthy subjects in the same period were selected as the healthy group. The serum TNF-α, CRP and IL-6 indexes of the two groups were detected. The serum TNF-α, CRP and IL-6 levels of CRF group and healthy group, CRF patients with different stages, CRF patients before and after hemodialysis treatment were compared.Results The levels of serum TNF-α, CRP and IL-6 in CRF group were higher than those in healthy group (P<0.05). The levels of serum TNF-α, CRP and IL-6 in different stages of CRF patients were in the order of stage Ⅳ＞stage Ⅲ＞stage Ⅱ＞stage Ⅰ (P<0.05). The levels of serum TNF-α, CRP and IL-6 in CRF group after hemodialysis were lower than those before hemodialysis (P<0.05).Conclusion Serum TNF-α, CRP and IL-6 are highly expressed in CRF patients, and their levels increase with the progression of disease stage and decrease after hemodialysis.

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更新日期/Last Update: 1900-01-01