[1]许凤姣.凝血功能检验在心脑血管疾病患者预后评估中的价值[J].医学信息,2023,36(11):138-141.[doi:10.3969/j.issn.1006-1959.2023.11.028]
　XU Feng-jiao.Value of Coagulation Function Test in the Prognosis Evaluation of Patients with Cardiovascular and Cerebrovascular Diseases[J].Journal of Medical Information,2023,36(11):138-141.[doi:10.3969/j.issn.1006-1959.2023.11.028]
点击复制

凝血功能检验在心脑血管疾病患者预后评估中的价值()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年11期
页码:
138-141
栏目:
诊疗技术
出版日期:
2023-06-01

文章信息/Info

Title:
Value of Coagulation Function Test in the Prognosis Evaluation of Patients with Cardiovascular and Cerebrovascular Diseases
文章编号:
1006-1959（2023）11-0138-04
作者:
许凤姣
（宜兴市中医医院检验科，江苏 宜兴 214200）
Author(s):
XU Feng-jiao
(Department of Laboratory Medicine,Yixing Hospital of Traditional Chinese Medicine,Yixing 214200,Jiangsu,China)
关键词:
凝血功能; 心脑血管疾病; 预后
Keywords:
Coagulation function; Cardiovascular and cerebrovascular diseases; Prognosis
分类号:
R743；R543
DOI:
10.3969/j.issn.1006-1959.2023.11.028
文献标志码:
A
摘要:
目的 研究凝血功能检验在心脑血管疾病患者预后中的判断价值。方法 回顾性分析2021年6月-2022年6月我院诊治的100例心脑血管疾病患者设为观察组，另选取同期在我院体检健康者100例设为对照组，均进行凝血功能检验[活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）、血浆凝血酶原时间（PT）、血浆凝血酶时间（TT）、D-二聚体（D-D）、抗凝血酶-Ⅲ（AT-Ⅲ）]，比较两组凝血功能各指标水平、不同预后患者凝血功能各指标水平。同时依据凝血功能指标异常情况，将观察组患者分为研究A组（＜3个指标比正常值增加或降低＜30%）和研究B组（≥3个指标低于或高于正常值30%），观察两组患者不同时间点凝血功能各指标水平及预后情况。结果 观察组APTT、PT、TT、D-D高于对照组，AT-Ⅲ、FIB低于对照组（P＜0.05）；预后良好者APTT、PT、TT、D-D低于病残者，AT-Ⅲ、FIB高于病残者（P＜0.05）；入院时及出血6、24 h，研究A组APTT、TT、FIB与研究B组比较，差异无统计学意义（P＞0.05）；而出血6、24 h，研究A组PT、AT-Ⅲ高于研究B组，D-D低于研究B组（P＜0.05）；研究A组致残、致死率均低于研究B组，良好率高于研究B组（P＜0.05）。结论 凝血功能检验在心脑血管疾病患者预后中具有重要的价值，心血管疾病患者均存在凝血功能异常，且预后较差。同时凝血功能指标异常情况越严重，患者出血风险越大，尤其是PT、D-D、AT-Ⅲ指标变化对出血风险具有一定的预测价值。
Abstract:
Objective To study the prognostic value of coagulation function test in patients with cardiovascular and cerebrovascular diseases. Methods A retrospective analysis of 100 patients with cardiovascular and cerebrovascular diseases diagnosed and treated in our hospital from June 2021 to June 2022 was set as the observation group, and 100 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. Coagulation function tests [activated partial thromboplastin time (APTT), fibrinogen (FIB), plasma prothrombin time (PT), plasma thrombin time (TT), D-dimer (D-D), antithrombin-Ⅲ (AT-Ⅲ)] were performed. The levels of coagulation function indexes and coagulation function indexes in patients with different prognosis were compared between the two groups. At the same time, according to the abnormal situation of coagulation function indexes, the patients in the observation group were divided into study group A (<3 indexes increased or decreased by <30% compared with the normal value) and study group B (≥3 indexes were lower or higher than the normal value by 30%). The levels of coagulation function indexes and prognosis of the two groups at different time points were observed.Results APTT, PT, TT and D-D in the observation group were higher than those in the control group, and AT-Ⅲ and FIB were lower than those in the control group (P<0.05). APTT, PT, TT and D-D in patients with good prognosis were lower than those in patients with disability, while AT-(P<0.05) and FIB were higher than those in patients with disability (P<0.05). There was no significant difference in APTT, TT and FIB between study group A and study group B at admission, 6 h and 24 h after bleeding (P>0.05). At 6 and 24 hours after bleeding, PT and AT-III in the study group A were higher than those in the study group B, and D-D was lower than that in the study group B (P<0.05). The disability and mortality rates of group A were lower than those of group B, and the good rate was higher than that of group B (P<0.05).Conclusion Coagulation function test has important value in the prognosis of patients with cardiovascular and cerebrovascular diseases. Patients with cardiovascular diseases have abnormal coagulation function and poor prognosis. At the same time, the more serious the abnormality of coagulation function indexes, the greater the risk of bleeding, especially the changes of PT, D-D and AT-Ⅲ indexes have certain predictive value for bleeding risk.

参考文献/References:

[1]史云光,张志刚,张瑞英,等.多发伤患者凝血功能指标在病情程度和预后判断中的作用研究[J].海军医学杂志,2017,38(2):170-174.[2]赵帅,张玉婷,崔艳姬,等.脑梗死患者同型半胱氨酸、血小板参数、凝血功能指标的临床检测意义[J].心脑血管病防治,2017,17(6):483-485.[3]沈华,马明洲,张铮,等.脂蛋白相关磷脂酶-A2对危重症心脑血管病患者预后的评估价值[J].内科急危重症杂志,2018,24(1):58-59.[4]廖娟.血常规和凝血功能检测在急性心肌梗死转归期的价值和确诊率评价[J].吉林医学,2021,15(7):46-49.[5]赖寒光,李勇,江峰,等.心脑血管疾病患者预后中凝血功能检验的判断价值[J].心血管病防治知识,2017,5(4):78-80.[6]Chen SX,Bao YW,Emergency DO.Evaluation value of calcitonin original and blood coagulation function for the prognosis of patients with sepsis[J].Journal of Molecular Imaging,2017,40(4):460-462.[7]刘婷.凝血指标对急性冠脉综合征患者PCI术中慢/无复流现象预测的研究[D].重庆:中国人民解放军陆军军医大学,2019.[8]腾龙.心脑血管疾病患者预后中凝血功能检验的应用价值分析[J].中国卫生标准管理,2016,7(22):142-143.[9]刘佳佳.心脑血管疾病患者预后中凝血功能检验的实施价值意见[J].血管与腔内血管外科杂志,2018,4(2):139-142,146. [10]汪波.凝血功能在急性重症创伤患者病情严重程度及预后中的价值研究[J].创伤外科杂志,2018,20(7):551-552.[11]王小卫,张婉琼,王荣辉,等.中重型创伤性颅脑损伤患者凝血功能变化及对预后的影响[J].实用医院临床杂志,2018,15(6):64-67.[12]常盼盼,刘畅,崇巍.严重创伤性脑损伤后凝血功能障碍与预后的关系[J].中国医科大学学报,2019,48(5):425-429.[13]陈鑫.损伤严重度评分联合D-二聚体对创伤患者死亡率的预测价值研究[D].广州:南方医科大学,2018.[14]马涛,郭少春,李立宏.急性期血栓弹力图与常规凝血功能检测在预测颅脑创伤患者预后中的作用[J].中华神经外科杂志,2020,36(3):278-280.[15]郭力鹏,梁滨,许青宗.氯吡格雷与替格瑞洛对经皮冠状动脉介入治疗术后患者凝血功能及心脑血管的影响[J].检验医学与临床,2018,15(5):654-656.[16]王刚.早期凝血功能检测对中重型颅脑损伤患者损伤程度及预后判断的临床价值[J].立体定向和功能性神经外科杂志,2019,32(1):38-41.[17]赵明学,陈涛,王艳秋,等.凝血检验指标对心脑血管疾病临床应用价值及预后分析[J].兰州大学学报(医学版),2020,46(6):62-66.[18]徐佳.血栓弹力图联合血小板聚集率试验检测冠脉慢血流患者抗血小板治疗的有效性及安全性[D].昆明:昆明医科大学,2019. [19]朱玲,伍晓梅,吴琳娜.凝血功能在心脑血管疾病患者检验中的参考意义[J].实用临床医药杂志,2018,22(4):13-15.

相似文献/References:

[1]刘方睿,余泽波.血栓弹力图对肝病患者凝血功能的评估及输血指导研究进展[J].医学信息,2018,31(08):42.[doi:10.3969/j.issn.1006-1959.2018.08.014]
　LIU Fang-rui,YU Ze-bo.Evaluation of Blood Coagulation in Patients with Liver Disease by Thromboelastogram and Research Progress on Blood Transfusion[J].Journal of Medical Information,2018,31(11):42.[doi:10.3969/j.issn.1006-1959.2018.08.014]
[2]金 英.维甲酸联合亚砷酸治疗急性早幼粒细胞白血病的疗效及对患者血清TAT、TM、PIC水平的影响[J].医学信息,2022,35(10):126.[doi:10.3969/j.issn.1006-1959.2022.10.030]
　JIN Ying.The Curative Effect of Retinoic Acid Combined with Arsenic Acid in the Treatment of Acute Promyelocytic Leukemia and its Effect on Serum TAT, TM and PIC Levels[J].Journal of Medical Information,2022,35(11):126.[doi:10.3969/j.issn.1006-1959.2022.10.030]
[3]李 靖.非高密度脂蛋白胆固醇与心脑血管疾病的关系研究[J].医学信息,2022,35(12):100.[doi:10.3969/j.issn.1006-1959.2022.12.024]
　LI Jing.Study on the Relationship Between Non-high Density Lipoprotein Cholesterol and Cardiovascular and Cerebrovascular Diseases[J].Journal of Medical Information,2022,35(11):100.[doi:10.3969/j.issn.1006-1959.2022.12.024]
[4]张恺悦,陈幼琼.乌司他丁联合血必净对烧伤后脓毒症患者凝血功能及全身炎性反应的影响研究[J].医学信息,2019,32(04):138.[doi:10.3969/j.issn.1006-1959.2019.04.044]
　ZHANG Kai-yue,CHEN You-qiong.Effect of Ulinastatin Combined with Xuebijing on Coagulation Function and Systemic Inflammatory Response in Patients with Sepsis after Burn[J].Journal of Medical Information,2019,32(11):138.[doi:10.3969/j.issn.1006-1959.2019.04.044]
[5]陈志萍.阿托伐他汀联合低分子肝素治疗短暂性脑缺血临床疗效[J].医学信息,2019,32(09):153.[doi:10.3969/j.issn.1006-1959.2019.09.051]
　CHEN Zhi-ping.Clinical Efficacy of Atorvastatin Combined with Low Molecular Weight Heparin in the Treatment of Transient Cerebral Ischemia[J].Journal of Medical Information,2019,32(11):153.[doi:10.3969/j.issn.1006-1959.2019.09.051]
[6]刘革铭,马洪俊,刘 毅,等.紫杉醇药物涂层球囊治疗急性心肌梗死的临床疗效及对患者术后凝血状态的影响[J].医学信息,2022,35(14):113.[doi:10.3969/j.issn.1006-1959.2022.14.027]
　LIU Ge-ming,MA Hong-jun,LIU Yi,et al.The Clinical Efficacy of Paclitaxel Drug Coated Balloon in the Treatment of Acute Myocardial Infarction and its Influence on Postoperative Coagulation State of Patients[J].Journal of Medical Information,2022,35(11):113.[doi:10.3969/j.issn.1006-1959.2022.14.027]
[7]吴 飞,余 路.尿毒清颗粒及前列地尔联合丹参酮治疗糖尿病肾病的疗效[J].医学信息,2019,32(13):153.[doi:10.3969/j.issn.1006-1959.2019.13.048]
　WU Fei,YU Lu.Therapeutic Effect of Urinary Granules and Alprostadil Combined with Tanshinone on Diabetic Nephropathy[J].Journal of Medical Information,2019,32(11):153.[doi:10.3969/j.issn.1006-1959.2019.13.048]
[8]关利平,李建文.凝血相关指标与乳腺癌新辅助化疗疗效预测的相关性研究[J].医学信息,2022,35(16):159.[doi:10.3969/j.issn.1006-1959.2022.16.041]
　GUAN Li-ping,LI Jian-wen.Study on Correlation Between Coagulation- related Indexes and Efficacy Prediction of Neoadjuvant Chemotherapy for Breast Cancer[J].Journal of Medical Information,2022,35(11):159.[doi:10.3969/j.issn.1006-1959.2022.16.041]
[9]曹 璐.机采血小板联合冷沉淀输注对颅脑外伤大出血患者凝血功能的影响[J].医学信息,2020,33(01):113.[doi:10.3969/j.issn.1006-1959.2020.01.034]
　CAO Lu.Effect of Mechanical Platelet Collection Combined with Cold Precipitation Infusion on Coagulation Function in Patients with Craniocerebral Trauma[J].Journal of Medical Information,2020,33(11):113.[doi:10.3969/j.issn.1006-1959.2020.01.034]
[10]胡可纯,张强惠子,刘海飞,等.抗凝药物预防PICC导管相关性血栓形成的Meta分析[J].医学信息,2023,36(19):23.[doi:10.3969/j.issn.1006-1959.2023.19.006]
　HU Ke-chun,ZHANG Qiang-hui-zi,LIU Hai-fei,et al.Meta-analysis of Anticoagulant Drugs for Prevention of PICC Catheter-related Thrombosis[J].Journal of Medical Information,2023,36(11):23.[doi:10.3969/j.issn.1006-1959.2023.19.006]

更新日期/Last Update: 1900-01-01