[1]李晓君.麦角新碱联合米索前列醇、缩宫素在胎盘早剥产后大出血的临床效果及对应激反应的影响[J].医学信息,2023,36(19):141-143,147.[doi:10.3969/j.issn.1006-1959.2023.19.031]
　LI Xiao-jun.Clinical Effect of Ergometrine Combined with Misoprostol and Oxytocin in Postpartum Hemorrhage of Placental Abruption and its Effect on Stress Response[J].Journal of Medical Information,2023,36(19):141-143,147.[doi:10.3969/j.issn.1006-1959.2023.19.031]
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麦角新碱联合米索前列醇、缩宫素在胎盘早剥产后大出血的临床效果及对应激反应的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年19期
页码:
141-143,147
栏目:
药物与临床
出版日期:
2023-10-01

文章信息/Info

Title:
Clinical Effect of Ergometrine Combined with Misoprostol and Oxytocin in Postpartum Hemorrhage of Placental Abruption and its Effect on Stress Response
文章编号:
1006-1959（2023）19-0141-04
作者:
李晓君
（永丰县人民医院妇产科，江西 永丰 331500）
Author(s):
LI Xiao-jun
(Department of Obstetrics and Gynecology,Yongfeng County People’s Hospital,Yongfeng 331500,Jiangxi,China)
关键词:
麦角新碱; 米索前列醇; 缩宫素; 胎盘早剥; 产后大出血; 应激反应
Keywords:
Ergometrine; Misoprostol; Oxytocin; Placental abruption; Postpartum hemorrhage; Stress reaction
分类号:
R714.46+1
DOI:
10.3969/j.issn.1006-1959.2023.19.031
文献标志码:
A
摘要:
目的 观察麦角新碱联合米索前列醇、缩宫素在胎盘早剥产后大出血中的临床效果及对应激反应的影响。方法 选取2019年1月-2022年3月我院诊治的60例胎盘早剥产后大出血产妇为研究对象，采用随机数字表法分为对照组（n=30）和观察组（n=30）。对照组采用缩宫素+米索前列醇治疗，观察组在对照组基础上联合麦角新碱治疗，比较两组临床效果、止血指标（出血量、出血持续时间、血红蛋白水平）、应激反应指标（收缩压、舒张压、心率）、不良反应发生率、母婴不良事件发生率。结果 观察组治疗总有效率为93.33%，高于对照组的80.00%（P＜0.05）；观察组出血量、出血持续时间均小于对照组，血红蛋白水平高于对照组（P＜0.05）；两组治疗后收缩压、舒张压、心率均高于治疗前（P＜0.05），但观察组与对照组比较，差异无统计学意义（P＞0.05）；观察组不良反应发生率与对照组比较，差异无统计学意义（P＞0.05）；观察组母婴不良事件发生率低于对照组（P＜0.05）。结论 麦角新碱联合米索前列醇、缩宫素在胎盘早剥产后大出血中的临床效果确切，可提升止血效果，降低母婴不良事件发生率，且对血压和心率影响较小，安全性较高。
Abstract:
Objective To observe the clinical effect of ergometrine combined with misoprostol and oxytocin in postpartum hemorrhage of placental abruption and its effect on stress response.Methods From January 2019 to March 2022, 60 parturients with postpartum hemorrhage of placental abruption diagnosed and treated in our hospital were selected as the research objects. They were divided into control group (n=30) and observation group (n=30) by random number table method. The control group was treated with oxytocin+misoprostol, and the observation group was treated with ergometrine on the basis of the control group. The clinical effect, hemostatic index (bleeding volume, bleeding duration, hemoglobin level), stress response index (systolic blood pressure, diastolic blood pressure, heart rate), incidence of adverse reactions, incidence of maternal and infant adverse events were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33%, which was higher than 80.00% in the control group (P<0.05). The amount of bleeding and the duration of bleeding in the observation group were less than those in the control group, and the hemoglobin level was higher than that in the control group (P<0.05). The systolic blood pressure, diastolic blood pressure and heart rate of the two groups after treatment were higher than those before treatment (P<0.05), but there was no significant difference between the observation group and the control group (P>0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). The incidence of maternal and infant adverse events in the observation group was lower than that in the control group (P<0.05).Conclusion Ergometrine combined with misoprostol and oxytocin has a definite clinical effect in postpartum hemorrhage of placental abruption, which can improve the hemostatic effect and reduce the incidence of maternal and infant adverse events. Meanwhile, it has little effect on blood pressure and heart rate, and has high safety in clinical treatment.

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更新日期/Last Update: 1900-01-01