[1]陈星妤,闵海燕,陶鹏飞,等.炎症因子在艾滋病合并淋巴瘤中的作用研究现况[J].医学信息,2024,37(03):180-183,188.[doi:10.3969/j.issn.1006-1959.2024.03.038]
　CHEN Xing-yu,MIN Hai-yan,TAO Peng-fei,et al.Research Status of the Role of Inflammatory Factors in AIDS Complicated with Lymphoma[J].Journal of Medical Information,2024,37(03):180-183,188.[doi:10.3969/j.issn.1006-1959.2024.03.038]
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炎症因子在艾滋病合并淋巴瘤中的作用研究现况()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年03期
页码:
180-183,188
栏目:
综述
出版日期:
2024-02-01

文章信息/Info

Title:
Research Status of the Role of Inflammatory Factors in AIDS Complicated with Lymphoma
文章编号:
1006-1959（2024）03-0180-05
作者:
陈星妤; 闵海燕; 陶鹏飞; 等
（1.大理大学公共卫生学院，云南 大理 671003；2.云南省传染病医院感染科，云南 昆明 650301）
Author(s):
CHEN Xing-yu; MIN Hai-yan; TAO Peng-fei; et al.
(1.School of Public Health,Dali University,Dali 671003,Yunnan,China;2.Department of Infectious Diseases,Yunnan Provincial Infectious Disease Hospital,Kunming 650301,Yunnan,China)
关键词:
艾滋病; 淋巴瘤; 白介素6; C反应蛋白; 降钙素原; D二聚体
Keywords:
AIDS; Lymphoma; Interleukin-6; C-reactive protein; Procalcitonin; D-dimer
分类号:
R512.91；R733.1
DOI:
10.3969/j.issn.1006-1959.2024.03.038
文献标志码:
A
摘要:
艾滋病相关淋巴瘤（ARL）是当今HIV/AIDS患者最常见的恶性肿瘤之一。IL-6是一种多效免疫调节活性的细胞因子，IL-6与肿瘤的发生发展、侵袭、转移及预后有密切关系。CRP是一个敏感的炎症指标，在感染发生早期就可升高，其在肝细胞中合成，主要是由于机体发生感染后通过IL-6、TNF-α等细胞因子诱导而合成。PCT可以作为一种全身炎症反应的生物标志物，临床上常用于鉴别细菌性感染和其他炎症感染。D-二聚体（D-D）是纤维蛋白形成和降解的敏感指标，手术、恶性肿瘤及肾功能不全等因素都可导致D-D升高。本文对IL-6、CRP、PCT和D-D对肿瘤特别是淋巴瘤作用的研究现况做一综述，以期为探讨上述炎症因子在艾滋病合并淋巴瘤中的作用提供参考。
Abstract:
AIDS-related lymphoma (ARL) is one of the most common malignant tumors in HIV/AIDS patients. IL-6 is a cytokine with pleiotropic immunomodulatory activity, which is closely related to the occurrence, development, invasion, metastasis and prognosis of tumors. CRP is a sensitive inflammatory marker, which can be increased in the early stage of infection, and is synthesized in hepatocytes, mainly due to the induction of cytokines such as IL-6 and TNF-α after infection. PCT can be used as a biomarker of systemic inflammatory response, which is commonly used to identify bacterial infections and other inflammatory infections. D-dimer(D-D) is a sensitive indicator of fibrin formation and degradation. Factors such as surgery, malignant tumors and renal insufficiency can lead to an increase in D-dimer. This article reviews the effects of IL-6, CRP, PCT and D-D on tumors, especially lymphoma, in order to provide a reference for exploring the role of the above inflammatory factors in AIDS complicated with lymphoma.

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更新日期/Last Update: 1900-01-01