[1]李瑞珍.血浆cTn-T、ME和NT-proBNP水平在急性胸痛患者主要心血管不良事件中的预测价值[J].医学信息,2024,37(07):135-138,142.[doi:10.3969/j.issn.1006-1959.2024.07.027]
　LI Rui-zhen.Predictive Value of Plasma cTn-T, ME and NT-proBNP Levels in Major Adverse Cardiovascular Events for Patients with Acute Chest Pain[J].Journal of Medical Information,2024,37(07):135-138,142.[doi:10.3969/j.issn.1006-1959.2024.07.027]
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血浆cTn-T、ME和NT-proBNP水平在急性胸痛患者主要心血管不良事件中的预测价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年07期
页码:
135-138,142
栏目:
论著
出版日期:
2024-04-01

文章信息/Info

Title:
Predictive Value of Plasma cTn-T, ME and NT-proBNP Levels in Major Adverse Cardiovascular Events for Patients with Acute Chest Pain
文章编号:
1006-1959（2024）07-0135-05
作者:
李瑞珍
（都江堰市妇幼保健院检验科，四川 都江堰 611830）
Author(s):
LI Rui-zhen
(Department of Clinical Laboratory,Maternal and Child Health Care Hospital of Dujiangyan,Dujiangyan 611830,Sichuan,China）
关键词:
急性胸痛; 肌钙蛋白; 甲氧基雌二醇; N-端脑钠肽前体; 主要心血管不良事件
Keywords:
Acute chest pain; Troponin; Methoxyestradiol; N-terminal pro-brain natriuretic peptide; Major adverse cardiovascular events
分类号:
R541
DOI:
10.3969/j.issn.1006-1959.2024.07.027
文献标志码:
A
摘要:
目的 探究血浆肌钙蛋白（cTn-T）、甲氧基雌二醇（ME）以及N-端脑钠肽前体（NT-proBNP）水平在急性胸痛患者主要心血管不良事件（MACE）中的预测价值。方法 选取2021年7月-2022年7月都江堰市妇幼保健院收治96例急性胸痛患者作为胸痛组，另将同期体检的90名健康者作为对照组；另依据胸痛组患者是否发生MACE分为MACE组与非MACE组，比较胸痛组与对照组、MACE组与非MACE组血浆cTn-T、ME和NT-proBNP水平，另分析影响急性胸痛患者MACE发生的危险因素，以及血浆cTn-T、ME和NT-proBNP水平预测急性胸痛患者MACE发生的价值。结果 胸痛组血浆cTn-T、NT-proBNP水平高于对照组，血浆ME水平低于对照组，差异有统计学意义（P＜0.05）；胸痛组患者出院后90 d出现紧急血运重建3例、脑卒中4例、心肌梗死5例、心源性休克3例、室颤/心室骤停3例、全因死亡1例，MACE发生率为19.79%（19/96）；MACE组血浆cTn-T、NT-proBNP水平高于非MACE组，血浆ME水平低于非MACE组，差异有统计学意义（P＜0.05）；多元Logictic回归分析显示，cTn-T水平上升、ME水平下降、NT-proBNP水平上升是急性胸痛患者MACE发生的独立危险因素；ROC曲线分析显示，血浆cTn-T、ME和NT-proBNP水平用于预测急性胸痛患者MACE发生AUC值分别为0.923、0.695和0.803。结论 急性胸痛患者血浆cTn-T、ME和NT-proBNP水平异常，其指标可有效预测MACE发生风险。
Abstract:
Objective To explore the predictive value of plasma troponin (cTn-T), methoxyestradiol (ME) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in major adverse cardiovascular events (MACE) for patients with acute chest pain.Methods A total of 96 patients with acute chest pain admitted to the emergency department of Dujiangyan Maternal and Child Health Hospital from July 2021 to July 2022 were selected as the chest pain group, and 90 healthy people who underwent physical examination during the same period were selected as the control group. According to the occurrence of MACE, the patients in the chest pain group were divided into MACE group and non-MACE group. The levels of plasma cTn-T, ME and NT-proBNP were compared between the chest pain group and the control group, the MACE group and the non-MACE group. The risk factors affecting the occurrence of MACE in patients with acute chest pain and the value of plasma cTn-T, ME and NT-proBNP levels in predicting the occurrence of MACE in patients with acute chest pain were analyzed.Results The levels of plasma cTn-T and NT-proBNP in the chest pain group were higher than those in the control group, and the level of plasma ME was lower than that in the control group (P<0.05). In the chest pain group, there were 3 cases of emergency revascularization, 4 cases of stroke, 5 cases of myocardial infarction, 3 cases of cardiogenic shock, 3 cases of ventricular fibrillation/ventricular arrest and 1 case of all-cause death 90 days after discharge, the incidence of MACE was 19.79% (19/96). The levels of plasma cTn-T and NT-proBNP in MACE group were higher than those in non-MACE group, and the level of plasma ME was lower than that in non-MACE group (P<0.05). Multivariate Logistic regression analysis showed that the increase of cTn-T level, the decrease of ME level and the increase of NT-proBNP level were independent risk factors for MACE in patients with acute chest pain. ROC curve analysis showed that the AUC values of plasma cTn-T, ME and NT-proBNP levels for predicting MACE in patients with acute chest pain were 0.923, 0.695 and 0.803, respectively.Conclusion The levels of plasma cTn-T, ME and NT-proBNP in patients with acute chest pain are abnormal, which can effectively predict the risk of MACE.

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更新日期/Last Update: 1900-01-01