[1]雷 锐,李 志.肌钙蛋白与心肌酶谱联合诊断冠心病的价值[J].医学信息,2022,35(22):154-156.[doi:10.3969/j.issn.1006-1959.2022.22.038]
　LEI Rui,LI Zhi.The Value of Combined Diagnosis of Cardiac Troponin and Myocardial Enzymes in Coronary Heart Disease[J].Journal of Medical Information,2022,35(22):154-156.[doi:10.3969/j.issn.1006-1959.2022.22.038]
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肌钙蛋白与心肌酶谱联合诊断冠心病的价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年22期
页码:
154-156
栏目:
诊疗技术
出版日期:
2022-11-15

文章信息/Info

Title:
The Value of Combined Diagnosis of Cardiac Troponin and Myocardial Enzymes in Coronary Heart Disease
文章编号:
1006-1959（2022）22-0154-03
作者:
雷 锐; 李 志
（佳木斯市中心医院心内三科1，心内二科2，黑龙江 佳木斯 154002）
Author(s):
LEI Rui; LI Zhi
(The Third Department of Cardiology1,the Second Department of Cardiology2,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
肌钙蛋白; 心肌酶谱; 冠心病; 空腹血糖
Keywords:
Cardiac troponin; Myocardial enzyme spectrum; Coronary heart disease; Fasting blood glucose
分类号:
R542.2
DOI:
10.3969/j.issn.1006-1959.2022.22.038
文献标志码:
A
摘要:
目的 分析肌钙蛋白Ⅰ（cTnⅠ）与心肌酶谱联合检测在冠心病诊断中的临床意义。方法 将我院2020年6月-2021年6月共126例冠心病患者作为研究组，另选取同期126例健康体检者作为对照组，均接受cTnⅠ以及心肌酶谱检测，比较两组空腹血糖（FPG）、血脂[总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）]、cTnⅠ、心肌酶谱水平[乳酸脱氢酶（LDH）、谷草转氨酶（AST）、磷酸肌酸激酶（CK）、α-羟丁酸脱氢酶（HBDH）、肌酸激酶同工酶（CK-MB）]以及cTnⅠ联合心肌酶谱诊断冠心病的效能。结果 研究组LDL-C、FPG高于对照组，差异有统计学意义（P＜0.05）；研究组TC、TG、HDL-C高于对照组，但差异无统计学意义（P＞0.05）；研究组cTnⅠ及心肌酶谱水平均高于对照组，差异有统计学意义（P＜0.05）；252例研究对象中，cTnⅠ检出阳性率48.41%，阴性率51.59%；心肌酶谱检出阳性率53.97%，阴性率46.03%；联合检测阳性率50.00%，阴性率50.00%；联合检测的灵敏度、特异度以及准确度均高于cTnⅠ与心肌酶谱单独检测，差异有统计学意义（P＜0.05）。结论 肌钙蛋白与心肌酶谱联合检测对冠心病的诊断具有重要意义，能够有效弥补单一检测的缺陷，提高诊断准确性，从而指导临床治疗，改善患者预后。
Abstract:
Objective To analyze the clinical significance of combined detection of cardiac troponin Ⅰ(cTnⅠ) and myocardial enzymes in the diagnosis of coronary heart disease.Methods A total of 126 patients with coronary heart disease in our hospital from June 2020 to June 2021 were selected as the study group, and 126 healthy subjects in the same period were selected as the control group. The fasting plasma glucose (FPG), blood lipids [total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C)], cTnⅠ, myocardial enzymes [lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK), α-hydroxybutyrate dehydrogenase (HBDH), creatine kinase isoenzyme (CK-MB)] and the efficacy of cTnⅠ combined with myocardial enzymes in the diagnosis of coronary heart disease were compared between the two groups.Results LDL-C and FPG in the study group were higher than those in the control group, and the difference was statistically significant (P<0.05). TC, TG and HDL-C in the study group were higher than those in the control group, but the difference was not statistically significant (P>0.05). The levels of cTnⅠ and myocardial enzymes in the study group were higher than those in the control group, and the differences were statistically significant (P<0.05). Among the 252 subjects, the positive rate of cTnⅠ was 48.41%, and the negative rate was 51.59%. The positive rate of myocardial enzymes was 53.97%, and the negative rate was 46.03%. The positive rate of combined detection was 50.00%, and the negative rate was 50.00%. The sensitivity, specificity and accuracy of combined detection were higher than those of cTnI and myocardial enzymes alone, and the difference was statistically significant (P<0.05).Conclusion The combined detection of troponin and myocardial enzymes is of great significance in the diagnosis of coronary heart disease, which can effectively make up for the defects of single detection and improve the diagnostic accuracy, so as to guide clinical treatment and improve the prognosis of patients.

参考文献/References:

[1]吴红丹,胡益蓉.心肌钙蛋白、肌酸激酶、总胆固醇及同型半胱氨酸的检测在心血管疾病诊断中的应用价值[J].标记免疫分析与临床,2019,26(4):671-674. [2]王蕾,王昌壁,朱玲,等.超敏肌钙蛋白T、血浆脂蛋白a和同型半胱氨酸联合检测在冠状动脉粥样硬化心脏病诊断中的应用价值[J].广西医科大学学报,2019,36(7):1152-1155. [3]武霞,杨清华,刘学键,等.24 h动态心电图联合心肌肌钙蛋白Ⅰ评价放射性心脏损伤的应用研究[J].中华放射肿瘤学杂志,2020,29(6):421-426. [4]庞阳,梁春,伍锋,等.冠心病患者血清肌腱蛋白C水平变化及临床意义[J].中国心血管杂志,2020,25(6):535-538. [5]朱思绮,朱敬轩,陈文娜.血脂检测联合心肌酶谱检测对气虚血瘀型冠心病的诊断价值[J].辽宁中医杂志,2021,48(7):8-10,后插3. [6]刘远友,曾金财,钟柳丹.冠心病患者血清胰岛素样生长因子结合蛋白-7浓度及其诊断价值[J].国际检验医学杂志,2019,40(21):2621-2624. [7]舒铭,金鹿,陈秋莹.血清铁调素检测对冠心病患者心肌损伤的诊断价值[J].检验医学,2019,34(9):783-786.[8]史菲,单伟超,张娜,等.血清hs-cTnT、Hcy、叶酸、维生素B12水平对冠心病患者冠状动脉病变严重程度的诊断价值[J].医学综述,2021,27(6):1244-1249. [9]苏彤,邵小南,杨玲,等.循环微小RNA-1对稳定性冠心病患者发生冠状动脉斑块破裂的早期诊断价值[J].中华危重病急救医学,2021,33(5):568-572. [10]曾伟雄,曾金财,方快发.冠心病患者血清NCAM-1、NT-proBNP和cTnI浓度及其诊断价值[J].海南医学,2020,31(23):3013-3016. [11]陈涛,孟祥平,余明,等.外周血成纤维细胞激活蛋白表达水平在冠心病诊断中的作用及临床意义[J].医学研究杂志,2019,48(12):32-35,107. [12]朱小慧,王长远,吉训明,等.急诊阵发性心房颤动患者血清肌钙蛋白水平升高的相关影响因素分析[J]. 现代生物医学进展,2019,19(11):2104-2107,2124. [13]张欢,夏豪,徐林,等.冠心病患者血浆富含半胱氨酸蛋白61表达水平及临床意义[J].广西医学,2019,41(18):2277-2280,2287.[14]Alghamry A,Hanna J,Pelecanos A,et al.Predictors of significant coronary artery disease in atrial fibrillation: Are cardiac troponins a useful measure[J].Int J Cardiol,2016,223:744-749.[15]陈强,张小威,姚蕾,等.血小板及心肌肌钙蛋白检测在冠心病患者临床诊治中的价值[J].检验医学与临床,2018,15(13):2002-2004.

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更新日期/Last Update: 1900-01-01