[1]韩佳妮.参芪地黄汤治疗早期糖尿病肾病的疗效[J].医学信息,2019,32(22):139-141.[doi:10.3969/j.issn.1006-1959.2019.22.047]
　HAN Jia-ni.Effect of Shenqi Dihuang Decoction in Treating Early Diabetic Nephropathy[J].Journal of Medical Information,2019,32(22):139-141.[doi:10.3969/j.issn.1006-1959.2019.22.047]
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参芪地黄汤治疗早期糖尿病肾病的疗效()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年22期
页码:
139-141
栏目:
中医中药
出版日期:
2019-11-15

文章信息/Info

Title:
Effect of Shenqi Dihuang Decoction in Treating Early Diabetic Nephropathy
文章编号:
1006-1959（2019）22-0139-03
作者:
韩佳妮
（常熟市中医院内分泌科，江苏 常熟 215500）
Author(s):
HAN Jia-ni
(Department of Endocrinology,Changshu Traditional Chinese Medicine Hospital,Changshu 215500, Jiangsu,China)
关键词:
糖尿病肾病; 参芪地黄汤; 胱抑素C; 尿蛋白
Keywords:
Diabetic nephropathy; Shenqi Dihuang Decoction; Cystatin C; Urine protein
分类号:
R587
DOI:
10.3969/j.issn.1006-1959.2019.22.047
文献标志码:
A
摘要:
目的 观察参芪地黄汤治疗早期糖尿病肾病的疗效。方法 选择2018年1月~12月我院收治的早期糖尿病肾病患者60例，按照随机数字表法分为治疗组和对照组，每组30例。两组均进行基础降糖降压治疗，对照组予缬沙坦治疗，治疗组在对照组治疗基础上加用参芪地黄汤治疗，比较两组治疗前后中医临床证候积分、肌酐（Scr）、尿素氮（BUN）、胱抑素C（Cys-C）、24h尿蛋白定量、临床疗效及安全性情况。结果 治疗后，两组中医临床证候积分较治疗前降低，治疗组中医临床证候积分低于对照组，差异有统计学意义（P＜0.05）。两组Scr、BUN、24h尿蛋白定量、Cys-C较治疗前降低，治疗组Scr、BUN、24h尿蛋白定量、Cys-C低于对照组，差异有统计学意义（P＜0.05）。治疗组总有效率为86.67%，高于对照组的63.33%，差异有统计学意义（P＜0.05）。结论 参芪地黄汤联合缬沙坦相比单用缬沙坦能更有效降低早期糖尿病肾病患者Scr、BUN、Cys-C水平，减少24h尿蛋白定量，降低中医临床证候积分，改善临床症状，疗效确切。
Abstract:
Objective To observe the efficacy of Shenqi Dihuang Decoction in the treatment of early diabetic nephropathy. Methods 60 patients with early diabetic nephropathy admitted to our hospital from January to December 2018 were enrolled. The patients were divided into treatment group and control group according to the random number table method, 30 cases in each group. The two groups were treated with basal hypoglycemic and hypotensive treatment. The control group was treated with valsartan. The treatment group was treated with Shenqi Dihuang Decoction on the basis of the control group. The TCM clinical syndrome scores and serum creatinine (Scr) were compared before and after treatment, urea nitrogen (BUN), cystatin C (Cys-C), 24h urine protein quantification, clinical efficacy and safety. Results After treatment, the scores of TCM clinical syndromes in the two groups were lower than those before treatment. The scores of TCM clinical syndromes in the treatment group were lower than those in the control group,the difference was statistically significant (P<0.05). The Scr, BUN, 24h urine protein and Cys-C were lower than those before treatment. The Scr, BUN, 24h urine protein and Cys-C in the treatment group were lower than the control group, the difference was statistically significant (P<0.05). The total effective rate of the treatment group was 86.67%, which was higher than that of the control group 63.33%,the difference was statistically significant (P<0.05). Conclusion Shenqi Dihuang Decoction combined with valsartan can effectively reduce the levels of Scr, BUN and Cys-C in patients with early diabetic nephropathy, reduce the quantification of 24h urine protein, reduce the clinical syndrome score of TCM, and improve clinical symptoms. The effect is exact.

参考文献/References:

[1]王莹莹,王文革,邓蓉蓉,等.甘肃省1828例肾活检病理资料及流行病学特点[J].中华肾脏病杂志,2019,35(3):212-214. [2]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中华糖尿病杂志,2018,10(1):4-67. [3]Mogensen CE.Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes [J].New England Joumal of Medicine,1984,310(6):356-360. [4]周鑫,陆俊峰,温泉.益气补肾化瘀方治疗早期糖尿病肾病临床观察[J].安徽中医药大学学报,2019,38(3):30-34. [5]吴仁凯,王杰,徐清喜.黄葵胶囊联合缬沙坦治疗糖尿病肾病临床疗效探讨[J].中国生化药物杂志,2017,37(6):236-237. [6]钱雅玉,朱玲,王世荣.二参益气补肾胶囊治疗糖尿病肾病辨证思路[J].中国民间疗法,2017,25(8):63-64. [7]宋高峰,郑义侯,孙惠力,等.2型糖尿病肾病患者不同分期中医证候特点分析[J].江西中医药,2019,50(7):27-30. [8]徐爱华.黄芪注射液在糖尿病肾病治疗中的应用效果及价值研究[J].实用中西医结合临床,2019,19(3):73-75. [9]易婷婷,栗萍,张明慧,等.黄芪对糖尿病肾病小鼠内质网应激中蛋白激酶R样内质网激酶通路的影响[J].中国临床药理学杂志,2019,35(8):785-787. [10]傅亮,李玉杰,来媛媛,等.黄芪注射液联合葛根素注射液对HK-2细胞TGF-β1/Smads及BMP-7/Smad5信号通路的影响[J].环球中医药,2019,12(3):343-347. [11]刘美霞,戚进,余伯阳.党参药理作用研究进展[J].海峡药学,2018,30(11):36-37. [12]曾艳,贾正平,张汝学.地黄化学成分及药理研究进展[J].中成药,2006,28(4):609-611. [13]徐硕,姜文清,邝咏梅,等.茯苓的化学成分及生物活性研究进展[J].西北药学杂志,2016,31(3):327-329. [14]田婷,陈华,冯亚龙,等.泽泻药理与毒理作用的研究进展[J].中药材,2014,37(11):2103-2108. [15]段煜,裴科,蔡皓,等.以黄芪-山茱萸治疗糖尿病肾病为例探究药对研究的新策略[J].中国中药杂志,2016,41(21):3919-3926. [16]邵礼梅,许世伟.山药化学成分及现代药理研究进展[J].中医药学报,2017,45(2):125-127.

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更新日期/Last Update: 2019-11-15