[1]曹鸣菲,雷德财,董秋月,等.NSCLC患者外周血血小板相关参数与临床病理特征的关系[J].医学信息,2023,36(18):90-93.[doi:10.3969/j.issn.1006-1959.2023.18.016]
　CAO Ming-fei,LEI De-cai,DONG Qiu-yue,et al.The Relationship Between Peripheral Blood Platelet Related Parameters and Clinicopathological Features in NSCLC Patients[J].Journal of Medical Information,2023,36(18):90-93.[doi:10.3969/j.issn.1006-1959.2023.18.016]
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NSCLC患者外周血血小板相关参数与临床病理特征的关系()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年18期
页码:
90-93
栏目:
论著
出版日期:
2023-09-15

文章信息/Info

Title:
The Relationship Between Peripheral Blood Platelet Related Parameters and Clinicopathological Features in NSCLC Patients
文章编号:
1006-1959（2023）18-0090-04
作者:
曹鸣菲; 雷德财; 董秋月; 等
（1.简阳市空分医院检验科，四川 简阳 641400；2.乐山市市中区肿瘤医院检验科，四川 乐山 641400；3.四川省肿瘤医院检验科，四川 成都 610041）
Author(s):
CAO Ming-fei; LEI De-cai; DONG Qiu-yue; et al.
(1.Department of Clinical Laboratoty,Kongfen Hispital,Jianyang 641400,Sichuan,China;2.Department of Clinical Laboratoty,Leshan Cancer Hospital,Leshan 614000,Sichuan,China;3.Department of Clinical Laboratoty,Sichuan Cancer Hospital,Chengdu 610041,Sichuan,China)
关键词:
非小细胞肺癌; 中性粒细胞与淋巴细胞比值; 血小板与淋巴细胞比值; 淋巴细胞与单核细胞比值
Keywords:
Non-small cell lung cancer; Neutrophil-lymphocyte ratio; Platelet-lymphocyte ratio; Lymphocyte-monocyte ratio
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2023.18.016
文献标志码:
A
摘要:
目的 探索NSCLC患者外周血血小板相关参数与临床病理特征的相关性，以及血小板相关参数在NSCLC诊治中的应用价值。方法 选取四川省肿瘤医院2021年1月-10月收治的300例NSCLC患者设为肺癌组，另收集同期健康体检人群100例设为对照组，比较两组外周血血小板相关参数表达水平，分析NSCLC患者外周血血小板相关参数与其临床病理特征的关系，另通过ROC曲线分析外周血血小板相关参数在NSCLC中的诊断价值。结果 肺癌组中PLR、NLR、MPV、PCT高于对照组，LMR低于对照组（P＜0.05），而两组PDW比较，差异无统计学意义（P＞0.05）；PLT与肿瘤直径有关，MPV与肿瘤分期、远端转移有关，PLR与病理类型、肿瘤分期以及远端转移有关，LMR与性别有关（P＜0.05）；ROC曲线显示，MPV和LMR诊断NSCLC的曲线下面积高于血小板其他参数。结论 NSCLC患者外周血血小板相关参数表达异常，与其临床病理特征密切相关，在NSCLC的诊断中具有重要价值。
Abstract:
Objective To explore the correlation between peripheral blood platelet-related parameters and clinicopathological features in patients with NSCLC, and the application value of platelet-related parameters in the diagnosis and treatment of NSCLC.Methods A total of 300 NSCLC patients admitted to Sichuan Cancer Hospital from January to October 2021 were selected as the lung cancer group, and 100 healthy people in the same period were collected as the control group. The expression levels of platelet-related parameters in peripheral blood of the two groups were compared, and the relationship between platelet-related parameters in peripheral blood of NSCLC patients and their clinicopathological characteristics was analyzed. In addition, the diagnostic value of platelet-related parameters in peripheral blood in NSCLC was analyzed by ROC curve.Results The PLR, NLR, MPV and PCT in the lung cancer group were higher than those in the control group, and the LMR was lower than that in the control group (P<0.05), while there was no significant difference in PDW between the two groups (P>0.05). PLT was related to tumor diameter, MPV was related to tumor stage and distant metastasis, PLR was related to pathological type, tumor stage and distant metastasis, and LMR was related to gender (P<0.05). ROC curve analysis showed that the area under the curve of MPV and LMR in NSCLC was higher than that of other platelet parameters.Conclusion The abnormal expression of platelet-related parameters in peripheral blood of NSCLC patients is closely related to their clinicopathological features and has important value in the diagnosis of NSCLC.

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更新日期/Last Update: 1900-01-01