[1]李平保.喹诺酮类药物联合盐酸氨溴索治疗慢阻肺对患者肺功能和生活质量的影响[J].医学信息,2025,38(06):139-142,146.[doi:10.3969/j.issn.1006-1959.2025.06.025]
　Li Pingbao.Effect of Quinolones Combined with Ambroxol Hydrochloride on Lung Function and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease[J].Journal of Medical Information,2025,38(06):139-142,146.[doi:10.3969/j.issn.1006-1959.2025.06.025]
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喹诺酮类药物联合盐酸氨溴索治疗慢阻肺对患者肺功能和生活质量的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年06期
页码:
139-142,146
栏目:
论著
出版日期:
2025-03-15

文章信息/Info

Title:
Effect of Quinolones Combined with Ambroxol Hydrochloride on Lung Function and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
文章编号:
1006-1959（2025）06-0139-05
作者:
李平保
乐安县中医院内科，江西 乐安 344300
Author(s):
Li Pingbao
Department of Internal Medicine, Le’an County Hospital of Traditional Chinese Medicine, Le’an 344300, Jiangxi, China
关键词:
喹诺酮类药物; 盐酸氨溴索; 慢阻肺; 肺功能; 生活质量
Keywords:
Quinolones;  Ambroxol hydrochloride;  Chronic obstructive pulmonary disease;  Lung function;  Quality of life
分类号:
R563
DOI:
10.3969/j.issn.1006-1959.2025.06.025
文献标志码:
A
摘要:
目的 分析喹诺酮类药物联合盐酸氨溴索治疗慢阻肺对患者肺功能和生活质量的影响。方法 选取2021年3月-2023年12月乐安县中医院收治的76例慢阻肺患者作为研究对象，按照随机数字表法将其分为对照组和研究组，每组各38例。对照组应用盐酸氨溴索注射液治疗，研究组在对照组基础上给予喹诺酮类药物盐酸左氧氟沙星治疗。比较两组治疗效果、肺功能[每分钟最大通气量（MVV）、用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、FEV1/FVC]、炎症因子指标水平[C-反应蛋白（CRP）、白细胞介素-2（IL-2）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）]及生活质量（生理机能、生理职能、躯体疼痛、一般健康状况、精力、社会功能、情感职能、精神健康）。结果 与对照组比较，研究组治疗总有效率更高（P＜0.05）。与对照组比较，研究组治疗后肺功能指标水平更高（P＜0.05），炎症因子指标水平更低（P＜0.05）。与对照组比较，研究组治疗后生活质量评分更高（P＜0.05）。结论 喹诺酮类药物联合盐酸氨溴索治疗慢阻肺患者的临床疗效确切，可有效改善患者的肺功能，减轻炎症反应，提高患者生活质量，建议临床应用。
Abstract:
Objective To analyze the effect of quinolones combined with ambroxol hydrochloride on lung function and quality of life in patients with chronic obstructive pulmonary disease.Methods A total of 76 patients with chronic obstructive pulmonary disease admitted to Le’an County Hospital of Traditional Chinese Medicine from March 2021 to December 2023 were selected as the research objects. According to the random number table method, they were divided into control group and study group, with 38 patients in each group. The control group was treated with ambroxol hydrochloride injection, and the study group was treated with quinolones levofloxacin hydrochloride on the basis of the control group. The therapeutic effect, lung function [maximum ventilation volume per minute (MVV), forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC ], inflammatory factor index levels [C-reactive protein (CRP), interleukin-2 (IL-2), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α)] and quality of life (physiological function, physiological function, physical pain, general health status, energy, social function, emotional function, mental health) were compared between the two groups.Results Compared with the control group, the total effective rate of the study group was higher (P<0.05). Compared with the control group, the level of lung function index in the study group was higher after treatment (P<0.05), and the level of inflammatory factor index was lower (P<0.05). Compared with the control group, the quality of life score of the study group was higher after treatment (P<0.05).Conclusion Quinolones combined with ambroxol hydrochloride is effective in the treatment of patients with chronic obstructive pulmonary disease, which can effectively improve the lung function of patients, reduce the inflammatory response, and improve the quality of life of patients. It is recommended for clinical application.

参考文献/References:

[1]徐辉,吴正霞,张和平,等.晚期肺癌合并慢阻肺化疗后肺部感染的病原菌耐药情况及干预对策[J].中国肿瘤临床与康复,2019,26(7):826-829.[2]唐火焰,刘虎,赵赟,等.慢性阻塞性肺疾病急性加重期患者痰培养菌种分布及耐药性分析[J].中国实用内科杂志,2019,39(5):447-451.[3]冯雄,吴坤亮,郑友彬,等.肺结核患者耐药性、危险因素及氟喹诺酮类药物联合治疗效果的研究[J].中国医院用药评价与分析,2020,20(9):1044-1048.[4]郑雅芳,袁林,苏德泉,等.喹诺酮类药物联合纤维支气管镜治疗儿童难治性肺炎支原体肺炎的体会[J].中国小儿急救医学,2020,27(11):871-873.[5]蔡水苗,陈珊珊,陈绵军,等.喹诺酮类治疗肺炎克雷伯菌感染的疗效及血清炎性因子变化[J].中华医院感染学杂志,2020,30(13):1992-1995.[6]张绍塘,陈伦,叶健.多索茶碱联合盐酸氨溴索对老年稳定期慢阻肺患者血清IL-33/sST2轴表达的影响[J].中国临床药理学杂志,2022,38(4):291-295.[7]王辉,张庆军,李小丽.盐酸氨溴索联合康复训练对慢阻肺的临床疗效及其对患者肺功能的影响研究[J].海南医学院学报,2020,26(5):351-354.[8]号素然,武巧玲,曹雪玲.千金苇茎汤联合可必特、氨溴索雾化吸入对老年慢性阻塞性肺疾病急性加重期的临床观察[J].河北医药,2018,40(24):3708-3711.[9]戚春辉,施国华,于佩雯.盐酸氨溴索注射液治疗老年慢性阻塞性肺疾病伴肺部感染的临床疗效及安全性[J].老年医学与保健,2022,28(6):1211-1213,1219.[10]马立敏.盐酸氨溴索治疗老年慢性阻塞性肺疾病合并肺部感染临床效果评价[J].中国药物与临床,2021,21(9):1536-1538.[11]武焕龙.盐酸氨溴索治疗老年慢性阻塞性肺疾病合并肺部感染疗效与药物不良反应[J].山西医药杂志,2021,50(6):966-968.[12]苏凝,王晋利,赵素霞,等.盐酸氨溴索在治疗慢性阻塞性肺疾病合并肺部感染患者中的效果分析[J].中国药物与临床,2021,21(14):2500-2501.[13]张帅,张虹霞,林蕊艳.硫酸沙丁胺醇联合盐酸氨溴索治疗慢性阻塞性肺疾病急性加重期患者的临床研究[J].中国临床药理学杂志,2023,39(14):1987-1991.[14]黄志龙,郭宝红,赵君.布地奈德联合氨溴索治疗慢性阻塞性肺疾病急性加重期临床疗效研究[J].临床军医杂志,2023,51(2):214-216.[15]路聪哲,陈洪,常艳,等.倍氯米松联合盐酸氨溴索对老年慢性阻塞性肺疾病患者肺功能及血气指标的影响[J].中华保健医学杂志,2020,22(4):441-444.[16]武玉斌,徐晓玲,吴祖凤,等.氧气驱动联合雾化吸入阿米卡星、布地奈德、氨溴索治疗慢性阻塞性肺病急性加重期的效果[J].中国老年学杂志,2020,40(7):1430-1432.[17]杨丽辉,卢宁,焦斌.脾多肽注射液联合盐酸氨溴索治疗慢性阻塞性肺疾病急性加重期临床观察[J].中国药业,2020,29(2):67-69.[18]王超,陈晓君,宋晓莉,等.莫西沙星左氧氟沙星序贯给药对老年重症慢性阻塞性肺疾病急性加重期患者呼吸功能微炎症的影响研究[J].河北医学,2023,29(4):685-689.[19]任佳荣,任登华.大剂量氨溴索联合左氧氟沙星治疗老年慢性阻塞性肺疾病伴重症肺炎患者的临床效果[J].临床与病理杂志,2020,40(10):2565-2568.[20]蔡丹磊,黄中伟,蔡琦,等.左氧氟沙星联合舒利迭对慢性阻塞性肺疾病急性加重期患者血清SAA、TGF-β1、copeptin、sICAM-1水平的影响[J].现代生物医学进展,2018,18(4):709-712,717.

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更新日期/Last Update: 1900-01-01