[1]谢桃李,孙礼宾.血清25-羟维生素D在过敏性紫癜中的研究[J].医学信息,2019,32(09):116-118.[doi:10.3969/j.issn.1006-1959.2019.09.038]
　XIE Tao-li,SUN Li-bin.Study on Serum 25-hydroxyvitamin D in Henoch-Sch?觟nlein Purpura[J].Journal of Medical Information,2019,32(09):116-118.[doi:10.3969/j.issn.1006-1959.2019.09.038]
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血清25-羟维生素D在过敏性紫癜中的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年09期
页码:
116-118
栏目:
临床研究
出版日期:
2019-05-01

文章信息/Info

Title:
Study on Serum 25-hydroxyvitamin D in Henoch-Sch?觟nlein Purpura
文章编号:
1006-1959（2019）09-0116-03
作者:
谢桃李; 孙礼宾
（安徽省安徽医科大学附属巢湖医院儿科，安徽 合肥 238000）
Author(s):
XIE Tao-li; SUN Li-bin
(Department of Pediatrics,Chaohu Hospital,Anhui Medical University,Anhui 238000,Hefei,China)
关键词:
过敏性紫癜; 25-羟维生素D; 补体; 免疫球蛋白
Keywords:
Henoch-Sch?觟nlein purpura; 25-hydroxyvitamin D; Complement; Immunoglobulin
分类号:
R725.5
DOI:
10.3969/j.issn.1006-1959.2019.09.038
文献标志码:
A
摘要:
目的 探讨血清25-羟维生素D[25-（OH）D] 维生素D水平与HSP发病的关系。方法 选择2017年12月~2018年12月至我院就诊的过敏性紫癜患儿49例设为实验组，另选取40例健康儿童设为健康对照组，采用化学发光法测定两组血清25-羟维生素D水平，免疫浊度法测定补体、免疫球蛋白并进行比较，分析其相关性。结果 实验组血清25-（OH）D水平为（19.061±6.572）ng/ml，低于健康对照组的（30.789±1.880）ng/ml，差异有统计学意义（t=-11.628，P＜0.05）；Pearson相关分析或Spearman秩相关分析示，实验组血清25-羟维生素D水平与免疫球蛋白IgA水平呈负相关（r=-0.352，P＜0.05），与补体（C3、C4）、免疫球蛋白（IgG、IgM）水平间无明显相关性（r=0.199、0.248、-0.165、-0.204，均P＞0.05）。结论 过敏性紫癜患儿中25羟维生素D可能参与了过敏性紫癜的发病过程。
Abstract:
Objective To investigate the relationship between serum 25-hydroxyvitamin D [25-(OH)D] vitamin D levels and the pathogenesis of HSP. Methods A total of 49 children with Henoch-Sch?觟nlein purpura who were admitted to our hospital from December 2017 to December 2018 were selected as the experimental group, and 40 healthy children were selected as the healthy control group. The serum of the two groups was determined by chemiluminescence method. - Hydroxyvitamin D levels, immunoturbidimetric assays for complement and immunoglobulin were compared and analyzed for correlation. Results The serum 25-(OH) D level in the experimental group was (19.061±6.572) ng/ml, which was lower than that in the healthy control group (30.789±1.880) ng/ml,the difference was statistically significant (t=-11.628, P<0.05); Pearson correlation analysis or Spearman rank correlation analysis showed that serum 25-hydroxyvitamin D levels in the experimental group were negatively correlated with immunoglobulin IgA levels (r=-0.352, P<0.05), and complement (C3, C4), There was no significant correlation between immunoglobulin (IgG, IgM) levels (r=0.199, 0.248, -0.165, -0.204, both P>0.05). Conclusion 25-hydroxyvitamin D may be involved in the pathogenesis of Henoch-Sch?nlein purpura in children with Henoch-Sch?觟nlein purpura.

参考文献/References:

[1]中华医学会儿科学分会免疫学组.儿童过敏性紫癜循证诊治建议[J].中华儿科杂志,2013,51(7):502-507.
[2]Colotta F,Jansson B,Bonelli F.Modulaton of inflammatoryand immune responses by vitamin D[J].J Autoimmun,2017(85):78-97.
[3]雷丽.维生素D缺乏的过敏性紫癜患儿外周血T细胞亚群、NK细胞计数变化[J].山东医药,2018,58(19):67-69.
[4]尹薇,陈晶.儿童过敏性紫癜免疫机制研究[J].中华实用儿科临床杂志,2017,32(21):287-290.
[5]Lau KK,Suzuki H,Novak J,et al.Pathogenesis of henoch-SchSnleinpurpura nephritis[J].Pediatr Nephrol,2010(25):19-26.
[6]王颖,苏娟.维生素D在自身免疫性疾病中的研究进展[J].风湿病与关节炎,2017,6(2):76-80.
[7]黄树平,钟涛,黄郁波,等.过敏性紫癜复发与血清25羟维生素D水平的相关性探讨[J].中国医学创新,2017,14(21):42-45.
[8]董显燕,钟涛,黄郁波,等.血清25-羟维生素D与过敏性紫癜发病风险关系的病例对照研究[J].重庆医学,2017,46(8):1076-1078,1081.
[9]张婷婷,吉晓菲,李少遊,等.过敏性紫癜患儿Th17、Treg细胞及IL-17、IL-23水平的测定[J].中国免疫学杂志,2016,32(12):1801-1804,1814.
[10]李海园,刘志伟.维生素D的免疫调节作用与儿童疾病[J].临床儿科杂志,2012,30(8):792-794.
[11]Fawaz L,Mrad MF,Kazan JM,et al.Comparative effect of 25(OH)D3 and 1,25(OH)2D3 on Th17 cell differentiation[J].Clin Immunol,2016(166-167):59-71.
[12]邹敏书,宋秋菊,聂国明,等.维生素D对过敏性紫癜患儿免疫功能的调节作用[J].解放军药学学报,2017,33(4):307-310.
[13]Chen S,Sims GP,Chen XX,et al.Modulatory effects of 1,25-dihydroxy vitamin D3 on human B cell differentiation[J] J Immunol,2007,179(3):1634-1647.
[14]张远达,董青伟,李荣敏,等.过敏性紫癜患儿25-羟基维生素D3水平变化及意义[J].中国当代儿科杂志,2017,19(3):292-295.
[15]范丽,刘衡,王予川,等.血清维生素D水平与过敏性紫癜患儿病情及治疗的关系[J].中国当代儿科杂志,2017,19(7):796-799.
[16]郑荣浩,刘冬蕾,黄力,等.过敏性紫癜患儿25-羟维生素D的表达及与免疫功能的关系[J].中国妇幼健康研究,2018,29(11):1392-1396.

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更新日期/Last Update: 2019-05-01