[1]李宇鑫,周 露,郭 旦,等.沙利度胺预防鼻咽癌放射性口腔粘膜炎的效果及对患者血清TNF-α的影响[J].医学信息,2021,34(01):149-151,154.[doi:10.3969/j.issn.1006-1959.2021.01.040]
　LI Yu-xin,ZHOU Lu,GUO Dan,et al.The Effect of Thalidomide in Preventing Radiation-induced Oral Mucositis of Nasopharyngeal Carcinoma and Its Influence on Patients’ Serum TNF-α[J].Medical Information,2021,34(01):149-151,154.[doi:10.3969/j.issn.1006-1959.2021.01.040]
点击复制

沙利度胺预防鼻咽癌放射性口腔粘膜炎的效果及对患者血清TNF-α的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年01期
页码:
149-151,154
栏目:
药物与临床
出版日期:
2021-01-01

文章信息/Info

Title:
The Effect of Thalidomide in Preventing Radiation-induced Oral Mucositis of Nasopharyngeal Carcinoma and Its Influence on Patients’ Serum TNF-α
文章编号:
1006-1959（2021）01-0149-04
作者:
李宇鑫; 周 露; 郭 旦; 等
（南华大学附属邵阳医院血液肿瘤科，湖南 邵阳 422000）
Author(s):
LI Yu-xin; ZHOU Lu; GUO Dan; et al.
(Department of Hematology and Oncology,Shaoyang Hospital Affiliated to University of South China, Shaoyang 422000,Hunan,China)
关键词:
沙利度胺; 鼻咽癌; 放射性口腔黏膜炎; TNF-α
Keywords:
Thalidomide; Nasopharyngeal carcinoma; Radiation-induced oral mucositis; TNF-α
分类号:
R739.6
DOI:
10.3969/j.issn.1006-1959.2021.01.040
文献标志码:
A
摘要:
目的 观察沙利度胺预防鼻咽癌（NPC）急性放射性口腔黏膜炎（RIOM）的疗效及对患者血清肿瘤坏死因子-α（TNF-α）的影响。方法 选取2019年1月~2020年4月南华大学附属邵阳医院72例初次行根治性放疗的鼻咽癌患者，随机将其分为对照组和试验组，各36例，对照组从放疗期间予以碳酸氢钠漱口，试验组在对照组的基础上口服沙利度胺。比较两组急性放射性口腔黏膜炎发生时间、程度及不良反应，评估两组患者放疗前后卡氏（KPS）评分并检测放疗前后血清TNF-α水平。结果 试验组RIOM的发生率及发生程度低于对照组，差异有统计学意义（P＜0.05）；试验组首次发生RIOM的时间晚于对照组，差异有统计学意义（P＜0.05）；放疗后，两组血清TNF-α水平均较放疗前升高，且对照组高于试验组，差异有统计学意义（P＜0.05）；两组不良反应发生情况比较，差异无统计学意义 （P＞0.05）；放疗后两组KPS评分较放疗前均降低，且对照组低于试验组，差异有统计学意义（P＜0.05）。结论 沙利度胺可降低鼻咽癌患者急性放射性口腔黏膜炎的发生率及严重程度，推迟其发生时间，降低患者血清TNF-α的水平，减轻炎症反应，改善鼻咽癌患者放疗后的体力状态。
Abstract:
Objective To observe the efficacy of thalidomide in preventing nasopharyngeal carcinoma (NPC) acute radiation-induced oral mucositis (RIOM) and its effect on serum tumor necrosis factor-α (TNF-α). Methods From January 2019 to April 2020, 72 patients with nasopharyngeal carcinoma who received radical radiotherapy at the Shaoyang Hospital of University of South China were selected and randomly divided into a control group and a test group, with 36 cases in each group. The control group received treatment from the radiotherapy period. Sodium bicarbonate was used to gargle, and the test group was given thalidomide orally on the basis of the control group. The occurrence time, degree and adverse reactions of acute radiation oral mucositis between the two groups were compared, the Karnofsky (KPS) scores before and after radiotherapy were evaluated and the serum TNF-α levels were detected before and after radiotherapy. Results The incidence and extent of RIOM in the test group were lower than those in the control group,the difference was statistically significant (P＜0.05); the first occurrence of RIOM in the test group was later than the control group,the difference was statistically significant (P＜0.05); after radiotherapy,levels of serum TNF-α in the two groups were higher than those before radiotherapy, and the control group was higher than the test group, the difference was statistically significant (P<0.05); the difference in the occurrence of adverse reactions between the two groups was not statistically significant (P>0.05); KPS scores in the two groups after radiotherapy were lower than before radiotherapy, and the control group was lower than the test group, the difference was statistically significant (P<0.05). Conclusion Thalidomide can reduce the incidence and severity of acute radiation-induced oral mucositis in patients with nasopharyngeal carcinoma, delay its occurrence, reduce the level of serum TNF-α, reduce inflammation, and improve the physical strength of patients with nasopharyngeal carcinoma after radiotherapy status.

参考文献/References:

[1]付振涛,郭晓雷,张思维,等.2014年中国鼻咽癌发病与死亡分析[J].中华肿瘤杂志,2018,40(8):566-571. [2]丁静华,苏法仁,薄琳.鼻咽癌研究进展[J].国际耳鼻咽喉头颈外科杂志,2017,41(1):43-46. [3]De Sanctis V,Bossi P,Sanguineti G,et al.Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies：literature review and consensus statements[J].Critical Reviews in Oncology/Hematology,2016(100):147-166. [4]中华医学会放射肿瘤治疗学分会.放射性口腔黏膜炎防治策略专家共识(2019)[J].中华放射肿瘤学杂志,2019,28(9):641-647. [5]中国鼻咽癌临床分期工作委员会.2010鼻咽癌调强放疗靶区及剂量设计指引专家共识[J].中华放射肿瘤学杂志,2011,20(4):267-269. [6]Muhammad MO,Nicoletta E,Thierry M.Radiation-Induced Oral Mucositis[J].Frontiers in Oncology,2017(7):89. [7]Sonis ST,Peterson RL,Edwards LJ,et al.Defining mechanisms of action of interleukin-11 on the progression of radiation-induced oral mucositis in hamsters[J].Oral Oncology,2000,36(4):373-381. [8]Frings K,Gruber S,Kuess P,et al.Modulation of radiation-induced oral mucositis by thalidomide[J].Strahlentherapie und Onkologie,2016,192(8):561-568. [9]Lima V,Brito GAC,Cunha FQ,et al.Effects of the tumour necrosis factor-αinhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters[J].European Journal of Oral Sciences,2010,113(3):210-217. [10]梁雷锋,衷敬华,严浩林,等.沙利度胺防治鼻咽癌放射性口腔黏膜炎的疗效观察[J].中国肿瘤临床,2017,44(23):1189-1193. [11]Song T,Ma X,Gu K,et al.Thalidomide represses inflammatory response and reduces radiculopathic pain by inhibiting IRAK-1 and NF-κB/p38/JNK signaling[J].Journal of Neuroimmunology,2016(290):1-8. [12]Hiramatsu T,Yoshizawa J,Miyaguni K,et al.Thalidomide potentiates etoposide-induced apoptosis in murine neuroblastoma through suppression of NF-κB activation[J].Pediatric Surgery International,2018,34(4):443-450. [13]王希方,秦思达,任宏,等.沙利度胺对晚期肺腺癌并恶液质综合征的疗效研究[J].现代肿瘤医学,2019,27(24):4359-4362.

相似文献/References:

[1]施雨南,陈志平,肖秋香,等.KAI1、Snail、Slug、E-cadherin在鼻咽癌中的表达及其与患者预后的关系[J].医学信息,2022,35(11):77.[doi:10.3969/j.issn.1006-1959.2022.11.021]
　SHI Yu-nan,CHEN Zhi-ping,XIAO Qiu-xiang,et al.The Expression of KAI1, Snail, Slug, and E-cadherin in Nasopharyngeal Carcinoma and its Relationship with the Prognosis of patients[J].Medical Information,2022,35(01):77.[doi:10.3969/j.issn.1006-1959.2022.11.021]
[2]林康杰,杨小敏.影响鼻咽癌放疗敏感性相关基因研究进展[J].医学信息,2018,31(22):26.[doi:10.3969/j.issn.1006-1959.2018.22.009]
　LIN Kang-jie,YANG Xiao-min.Advances in Research on Genes Related to Radiotherapy Sensitivity of Nasopharyngeal Carcinoma[J].Medical Information,2018,31(01):26.[doi:10.3969/j.issn.1006-1959.2018.22.009]
[3]龚建忠,韦 燕,潘琦津,等.锌剂防治鼻咽癌同步放化疗患者放射性口咽炎的效果分析[J].医学信息,2019,32(17):63.[doi:10.3969/j.issn.1006-1959.2019.17.020]
　GONG Jian-zhong,WEI Yan,PAN Qi-jin,et al.Effect of Zinc on Prevention and Treatment of Radiation Oropharyngeal Mucositis in Patients with Nasopharyngeal Carcinoma Treated with Concurrent Chemoradiotherapy[J].Medical Information,2019,32(01):63.[doi:10.3969/j.issn.1006-1959.2019.17.020]
[4]潘兴喜,杨 文,李飞龙,等.鼻咽癌咽后淋巴结转移规律对放疗靶区设计的影响[J].医学信息,2019,32(23):107.[doi:10.3969/j.issn.1006-1959.2019.23.029]
　PAN Xing-xi,YANG Wen,LI Fei-long,et al.Effect of Post-Pharyngeal Lymph Node Metastasis on the Design of Radiotherapy Target Area in Nasopharyngeal Carcinoma[J].Medical Information,2019,32(01):107.[doi:10.3969/j.issn.1006-1959.2019.23.029]
[5]周 梅,赵 刚,禤瑞霞,等.鼻咽癌中IKKβ和Ki-67的表达与肿瘤侵袭转移的关系[J].医学信息,2022,35(17):22.[doi:10.3969/j.issn.1006-1959.2022.17.005]
　ZHOU Mei,ZHAO Gang,XUN Rui-xia,et al.Expression of IKKβ and Ki-67 in Nasopharyngeal Carcinoma and its Relationship with Tumor Invasion and Metastasis[J].Medical Information,2022,35(01):22.[doi:10.3969/j.issn.1006-1959.2022.17.005]
[6]杨 柳,余忠华.鼻咽癌放疗所致口腔黏膜反应的防治研究[J].医学信息,2020,33(05):56.[doi:10.3969/j.issn.1006-1959.2020.05.017]
　YANG Liu,YU Zhong-hua.Study on Prevention and Treatment of Oral Mucosa Reaction Caused by Nasopharyngeal Carcinoma Radiotherapy[J].Medical Information,2020,33(01):56.[doi:10.3969/j.issn.1006-1959.2020.05.017]
[7]罗艳红,张 颖,郑春艳,等.沙利度胺预防宫颈癌放疗所致急性放射性肠炎的效果及对IL-6水平的影响[J].医学信息,2020,33(21):143.[doi:10.3969/j.issn.1006-1959.2020.21.044]
　LUO Yan-hong,ZHANG Ying,ZHENG Chun-yan,et al.The Effect of Thalidomide in Preventing Acute Radiation Enteritis Caused by Radiotherapy of Cervical Cancer and Its Effect on IL-6 Level[J].Medical Information,2020,33(01):143.[doi:10.3969/j.issn.1006-1959.2020.21.044]
[8]陈 雪,张海龙.沙利度胺联合白芍总苷胶囊治疗复发性口腔溃疡的疗效[J].医学信息,2021,34(02):155.[doi:10.3969/j.issn.1006-1959.2021.02.043]
　CHEN Xue,ZHANG Hai-long.Therapeutic Effect of Thalidomide Combined with Total Glucosides of Paeony Capsules in the Treatment of Recurrent Oral Ulcer[J].Medical Information,2021,34(01):155.[doi:10.3969/j.issn.1006-1959.2021.02.043]
[9]陆柔凤,葛 微.鼻咽癌影响因素研究热点与前沿分析[J].医学信息,2022,35(22):34.[doi:10.3969/j.issn.1006-1959.2022.22.006]
　LU Rou-feng,GE Wei.Research Focus and Frontier Analysis of Influencing Factors of Nasopharyngeal Carcinoma[J].Medical Information,2022,35(01):34.[doi:10.3969/j.issn.1006-1959.2022.22.006]
[10]林彩星,陈 罡,杨振东,等.汉黄芩素抑制鼻咽癌细胞增殖、迁移和侵袭能力的研究[J].医学信息,2023,36(10):71.[doi:10.3969/j.issn.1006-1959.2023.10.017]
　LIN Cai-xing,CHEN Gang,YANG Zhen-dong,et al.Effects of Wogonin on Proliferation, Migration and Invasion of Nasopharyngeal Carcinoma Cells[J].Medical Information,2023,36(01):71.[doi:10.3969/j.issn.1006-1959.2023.10.017]

更新日期/Last Update: 1900-01-01