[1]潘 玲.非小细胞肺癌EGFR-TKI耐药机制及治疗策略[J].医学信息,2021,34(07):1-5.[doi:10.3969/j.issn.1006-1959.2021.07.001]
 PAN Ling.Mechanisms and Treatment Strategies of EGFR-TKI Resistance in Non-small Cell Lung Cancer[J].Medical Information,2021,34(07):1-5.[doi:10.3969/j.issn.1006-1959.2021.07.001]
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非小细胞肺癌EGFR-TKI耐药机制及治疗策略()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年07期
页码:
1-5
栏目:
出版日期:
2021-04-01

文章信息/Info

Title:
Mechanisms and Treatment Strategies of EGFR-TKI Resistance in Non-small Cell Lung Cancer
文章编号:
1006-1959(2021)07-0001-05
作者:
潘 玲
(桂林市中医医院肿瘤科,广西 桂林 541002)
Author(s):
PAN Ling
(Department of Oncology,Guilin Traditional Chinese Medicine Hospital,Guilin 541002,Guangxi,China)
关键词:
非小细胞肺癌EGFR-TKI耐药
Keywords:
Non-small cell lung cancerEGFR-TKIDrug resistance
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2021.07.001
文献标志码:
A
摘要:
非小细胞肺癌(NSCLC)为常见恶性肿瘤之一,在所有类型的肺癌中占80%。很多NSCLC患者在确诊时已为晚期,含铂双药联合化疗成为了此类患者的标准治疗方案。但化疗药物对改善晚期NSCLC患者的生存期作用有限。表皮生长因子受体(EGFR)-酪氨酸激酶抑制剂(TKI)能够显著改善EGFR突变的NSCLC患者的生存,但大部分NSCLC患者经EGFR-TKI治疗后会产生耐药。本文综述了近年来NSCLC患者EGFR-TKI耐药的机制和治疗新策略。
Abstract:
Non-small cell lung cancer (NSCLC) is one of the common malignant tumors, accounting for 80% of all types of lung cancer.Many NSCLC patients are already at an advanced stage at the time of diagnosis, and platinum-containing dual-drug combination chemotherapy has become the standard treatment for such patients.However, chemotherapy drugs have limited effect on improving the survival of patients with advanced NSCLC. Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) can significantly improve the survival of NSCLC patients with EGFR mutations.However, most NSCLC patients will develop drug resistance after EGFR-TKI treatment.This article reviews the mechanisms and new treatment strategies of EGFR-TKI resistance in NSCLC patients in recent years.

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更新日期/Last Update: 1900-01-01