[1]张培文.舍曲林治疗合并焦虑抑郁的慢性阻塞性肺疾病患者的效果研究[J].医学信息,2021,34(14):148-150.[doi:10.3969/j.issn.1006-1959.2021.14.041]
　ZHANG Pei-wen.Effect of Sertraline in the Treatment of Chronic Obstructive Pulmonary Disease Patients with Anxiety and Depression[J].Medical Information,2021,34(14):148-150.[doi:10.3969/j.issn.1006-1959.2021.14.041]
点击复制

舍曲林治疗合并焦虑抑郁的慢性阻塞性肺疾病患者的效果研究()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年14期
页码:
148-150
栏目:
药物与临床
出版日期:
2021-07-15

文章信息/Info

Title:
Effect of Sertraline in the Treatment of Chronic Obstructive Pulmonary Disease Patients with Anxiety and Depression
文章编号:
1006-1959（2021）14-0148-03
作者:
张培文
（济宁市精神病防治院躯体疾病合并精神疾病科，山东 济宁 272051）
Author(s):
ZHANG Pei-wen
(Department of Physical and Mental Diseases,Jining Psychiatric Hospital,Jining 272051,Shandong,China)
关键词:
舍曲林; 焦虑; 抑郁; 慢性阻塞性肺疾病
Keywords:
Sertraline; Anxiety; Depression; Chronic obstructive pulmonary disease
分类号:
R749.99
DOI:
10.3969/j.issn.1006-1959.2021.14.041
文献标志码:
A
摘要:
目的 观察舍曲林治疗合并焦虑抑郁的慢性阻塞性肺疾病患者临床治疗效果。方法 选取2018年2月~2020年8月在我院诊治的72例合并焦虑抑郁的慢性阻塞性肺疾病患者为研究对象，采用随机数字表法分为对照组和观察组，各36例。对照组采用常规治疗，观察组在常规治疗基础上联合舍曲林治疗，比较两组肺功能指标、焦虑和抑郁评分、血气指标、6 min步行试验距离、生活质量以及不良反应发生情况。结果 治疗后，两组FEV1、FVC、PEF均高于治疗前，且观察组高于对照组，差异有统计学意义（P＜0.05）；治疗后两组焦虑、抑郁评分均低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）；治疗后，两组PaCO2低于治疗前，PaO2、SaO2水平均高于治疗前，且观察组PaCO2低于对照组，PaO2、SaO2水平高于对照组，差异有统计学意义（P＜0.05）；干预后，两组6 min步行试验距离、生活质量评分均大于干预前，且观察组大于对照组（P＜0.05）；观察组不良反应发生率为8.33%，与对照组的11.11%比较，差异无统计学意义（P＞0.05）。结论 舍曲林治疗合并焦虑抑郁的慢性阻塞性肺疾病患者效果确切，可改善患者肺功能和血气指标，减轻抑郁和焦虑症状，提高患者运动功能，提升生活质量，且不会增加临床不良反应。
Abstract:
Objective To observe the clinical treatment of patients with chronic obstructive pulmonary diseases in the treatment of combined anxiety and depression. Methods 72 patients with chronic obstructive pulmonary disease combined with anxiety and depression were treated in our hospital from February 2018 to August 2020, Using random number table method, they were divided into control group and observation group, each with 36 cases.The control group was treated with conventional treatment, and the observation group was treated with sertraline on the basis of conventional treatment. The pulmonary function indexes, anxiety and depression scores, blood gas indexes, 6-min walk test distance, quality of life, and adverse reactions were compared between the two groups. Results After treatment, the FEV1, FVC, and PEF of the two groups were higher than before treatment, and the observation group was higher than the control group, the difference was statistically significant (P＜0.05);After treatment, the anxiety and depression scores of the two groups were lower than those before treatment, and the observation group was lower than the control group, the difference was statistically significant (P＜0.05);After treatment, PaCO2 in the two groups was lower than before treatment, PaO2 and SaO2 levels were higher than before treatment, PaCO2 in the observation group was lower than that in the control group, PaO2 and SaO2 levels were higher than in the control group, the difference was statistically significant (P＜0.05);After the intervention, the 6-min walking test distance and quality of life scores of the two groups were greater than those before the intervention, and the observation group was greater than the control group (P＜0.05);The incidence of adverse reactions in the observation group was 8.33%, compared with 11.11% in the control group, the difference was not statistically significant (P＞0.05). Conclusion Sertraline is effective in treating chronic obstructive pulmonary disease patients with anxiety and depression.It can improve patients’ lung function and blood gas indicators, reduce symptoms of depression and anxiety, improve patients’ motor function, improve quality of life, and will not increase clinical adverse reactions.

参考文献/References:

[1]齐佳华,李丽蕊,李文爽,等.慢阻肺合并高血压病患者特点及焦虑发生危险因素的调查[J].临床肺科杂志,2018,23(1):1767-1771. [2]尤再春,王关嵩.慢性阻塞性肺疾病合并焦虑抑郁判断及对策[J].中国实用内科杂志,2020,40(10):805-809. [3]郭欣,李玉超,刘震宇.氟哌噻吨美利曲辛片对慢性阻塞性肺疾病合并焦虑抑郁症状患者的临床影响[J].中华老年多器官疾病杂志,2019,18(7):523-526. [4]Kocakaya D,Yildizeli SO,Kocakaya O,et al.Anxiety and depression in patients with chronic obstructive pulmonary disease and their relation to serum vitamin D levels[J].Marmara Medical Journal,2018,31(1):33-40. [5]应少聪,周向东,刘益琼,等.康复训练结合健康教育对老年慢性阻塞性肺疾病患者生活质量及其心理健康状况的影响[J].中华物理医学与康复杂志,2014,36(5):333-336. [6]邹志,杨婵娟,陈开容,等.抗焦虑抑郁辅助治疗对慢性阻塞性肺疾病患者临床疗效观察[J].临床肺科杂志,2016,21(9):1627-1631. [7]林南生,周尧生,何深文,等.慢性阻塞性肺疾病患者抑郁和焦虑发生的危险因素分析[J].岭南急诊医学杂志,2015,20(4):290－293. [8]牛爽,杨谦,康蓓,等.舍曲林早期治疗对脑卒中患者焦虑、抑郁情绪和认知功能影响观察[J].国际精神病学杂志,2019,46(2):309-311. [9]郑丽梅,李田.抗抑郁剂治疗对伴有抑郁和焦虑症状的慢性阻塞性肺疾病患者肺功能的影响[J].南京医科大学学报,2018,38(2):247-250. [10]张焱,周勇杰.伴不同焦虑和(或)抑郁障碍的冠心病患者心率变异性情况及舍曲林的应用效果[J].广东医学,2017,38(14):2219-2223. [11]辛瑾琛,黄丽萍.慢性阻塞性肺疾病稳定期患者焦虑抑郁水平对机体状态的影响[J].新中医,2014,46(8):47-49. [12]周红平,曹栋,韩淑辉,等.草酸艾司西酞普兰联合黛力新对脑卒中后抑郁障碍患者的疗效及对血清指标的影响[J].国际精神病学杂志,2018,45(4):135-138. [13]陈义云,段胜稳.糖皮质激素对慢性阻塞性肺疾病患者焦虑抑郁症状的影响[J].社区医学杂志,2015,11(1):41-42. [14]袁雨来,鼓素华,王俊峰,等.中西医结合治疗慢性阻塞性肿疾病合并焦虑抑郁状态临床观察[J].山西中医,2015,30(12):23-24. [15]韩健,李友林.温润辛金培脾法对慢性阻塞性肺疾病合并焦虑抑郁(肺脾两虚型)患者的疗效观察[J].中医药杂志,2015,30(5):1648-1651.

相似文献/References:

[1]谢勇丽,苏晓清,张雅薇.糖尿病痛性周围神经病变患者情绪调查分析[J].医学信息,2018,31(05):14.[doi:10.3969/j.issn.1006-1959.2018.05.005]
　XIE Yong-li,SU Xiao-qing,ZHANG Ya-wei.Investigation and Analysis of Mood in Patients with Diabetic Peripheral Neuropathy[J].Medical Information,2018,31(14):14.[doi:10.3969/j.issn.1006-1959.2018.05.005]
[2]赵伟潭,朱祥路.焦虑在心血管内科的存在现况研究[J].医学信息,2018,31(05):53.[doi:10.3969/j.issn.1006-1959.2018.05.019]
　ZHAO Wei-tan,ZHU Xiang-lu.Research on the Current Status of Anxiety in Cardiovascular Medicine[J].Medical Information,2018,31(14):53.[doi:10.3969/j.issn.1006-1959.2018.05.019]
[3]任庆玲.聚焦解决模式对慢阻肺患者主要照顾者的 照顾负担及负性情绪影响的研究[J].医学信息,2018,31(07):162.[doi:10.3969/j.issn.1006-1959.2018.07.057]
　REN Qing-ling.Study on the Effect of Focus-resolving Model on the Burden of Care and Negative Emotions of Primary Caregivers in Patients with Chronic Obstructive Pulmonary Disease[J].Medical Information,2018,31(14):162.[doi:10.3969/j.issn.1006-1959.2018.07.057]
[4]陈功琦,梁道博.利培酮联合舍曲林治疗精神分裂症阴性症状 疗效和安全性的Meta分析[J].医学信息,2018,31(10):65.[doi:10.3969/j.issn.1006-1959.2018.10.020]
　CHEN Gong-qi,LIANG Dao-bo.Meta Analysis of Efficacy and Safety of Risperidone Combined with Sertraline in the Treatment of Schizophrenia with Negative Symptoms[J].Medical Information,2018,31(14):65.[doi:10.3969/j.issn.1006-1959.2018.10.020]
[5]范银燕.舍曲林联合丙戊酸钠对癫痫伴精神障碍的疗效评价[J].医学信息,2018,31(12):134.[doi:10.3969/j.issn.1006-1959.2018.12.041]
　FAN Yin-yan.Efficacy of Sertraline Combined with Sodium Valproate in the Treatment of Epilepsy with Mental Disorders[J].Medical Information,2018,31(14):134.[doi:10.3969/j.issn.1006-1959.2018.12.041]
[6]王鲁奎,高春梅.大学生焦虑与血压影响因素及相关性分析[J].医学信息,2018,31(14):133.[doi:10.3969/j.issn.1006-1959.2018.14.040]
　WANG Lu-kui,GAO Chun-mei.Influencing Factors and Correlation between Anxiety and Blood Pressure among College Students[J].Medical Information,2018,31(14):133.[doi:10.3969/j.issn.1006-1959.2018.14.040]
[7]田 野,徐桂娟,宋 震,等.沙盘游戏治疗对轻中度抑郁障碍患者 个人和社会功能的影响分析[J].医学信息,2018,31(17):86.[doi:10.3969/j.issn.1006-1959.2018.17.026]
　TIAN Ye,XU Gui-juan,SONG Zhen,et al.Analysis of the Influence of Sand Table Game Therapy on Personal and Social Function of Patients with Mild to Moderate Depressive Disorder[J].Medical Information,2018,31(14):86.[doi:10.3969/j.issn.1006-1959.2018.17.026]
[8]杨 慧.手术室细节护理改善手术患者负性情绪和并发症的临床观察[J].医学信息,2018,31(17):176.[doi:10.3969/j.issn.1006-1959.2018.17.056]
　YANG Hui.Clinical Observation of Operating Room Detail Nursing to Improve Negative Emotions and Complications in Patients undergoing Surgery[J].Medical Information,2018,31(14):176.[doi:10.3969/j.issn.1006-1959.2018.17.056]
[9]常丽苹.大学生睡眠质量与焦虑抑郁状况及其相关性分析[J].医学信息,2018,31(18):106.[doi:10.3969/j.issn.1006-1959.2018.18.033]
　CHANG Li-ping.Analysis of College Students' Sleep Quality,Anxiety and Depression Status and Their Correlation[J].Medical Information,2018,31(14):106.[doi:10.3969/j.issn.1006-1959.2018.18.033]
[10]蒋 薇.全程心理干预对前列腺癌根治术后患者焦虑抑郁情绪的影响研究[J].医学信息,2018,31(21):178.[doi:10.3969/j.issn.1006-1959.2018.21.053]
　JIANG Wei.Effect of Comprehensive Psychological Intervention on Anxiety and Depression in Patients with Prostate Cancer after Radical Prostatectomy[J].Medical Information,2018,31(14):178.[doi:10.3969/j.issn.1006-1959.2018.21.053]

更新日期/Last Update: 1900-01-01