[1]刘革铭,马洪俊,刘 毅,等.紫杉醇药物涂层球囊治疗急性心肌梗死的临床疗效及对患者术后凝血状态的影响[J].医学信息,2022,35(14):113-115.[doi:10.3969/j.issn.1006-1959.2022.14.027]
　LIU Ge-ming,MA Hong-jun,LIU Yi,et al.The Clinical Efficacy of Paclitaxel Drug Coated Balloon in the Treatment of Acute Myocardial Infarction and its Influence on Postoperative Coagulation State of Patients[J].Medical Information,2022,35(14):113-115.[doi:10.3969/j.issn.1006-1959.2022.14.027]
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紫杉醇药物涂层球囊治疗急性心肌梗死的临床疗效及对患者术后凝血状态的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年14期
页码:
113-115
栏目:
临床研究
出版日期:
2022-07-15

文章信息/Info

Title:
The Clinical Efficacy of Paclitaxel Drug Coated Balloon in the Treatment of Acute Myocardial Infarction and its Influence on Postoperative Coagulation State of Patients
文章编号:
1006-1959（2022）14-0113-03
作者:
刘革铭; 马洪俊; 刘 毅; 等
（天津市滨海新区海滨人民医院心血管内科，天津 300280）
Author(s):
LIU Ge-ming; MA Hong-jun; LIU Yi; et al.
(Department of Cardiology,Haibin people’s Hospital,Binhai New Area,Tianjin 300280,China)
关键词:
急性心肌梗死; 紫杉醇药物涂层球囊; 凝血功能; 心血管事件
Keywords:
Acute myocardial infarction; Paclitaxel drug-coated balloon; Coagulation function; Cardiovascular events
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2022.14.027
文献标志码:
A
摘要:
目的 探讨紫杉醇药物涂层球囊（DCB）治疗急性心肌梗死（AMI）的疗效，以及对患者术后凝血状态影响。方法 选取2020年5月-2021年5月我院就诊的采取经皮冠脉介入手术（PCI）治疗的80例AMI患者作为研究对象，按照随机数字表法将其分为对照组和观察组，各40例，对照组手术过程中实施药物洗脱支架（DES）治疗，观察组则给予紫杉醇DCB治疗，比较两组治疗效果、凝血功能指标[凝血酶原时间（PT）、活化部分凝血酶时间（APTT）、凝血酶时间（TT）和纤维蛋白原（FIB）]、心血管事件发生率（MACE）、再通率和再闭塞率。结果 观察组总有效率为97.50%，高于对照组85.00%，差异有统计学意义（P＜0.05）；观察组PT、APTT 、TT和FIB水平均高于对照组，差异有统计学意义（P＜0.05）；观察组MACE发生率为5.00%，低于对照组的20.00%，差异有统计学意义（P＜0.05）；观察组再闭塞率为5.00%，低于对照组的22.50%，差异有统计学意义（P＜0.05）；两组再通率比较，差异无统计学意义（P＞0.05）。结论 紫杉醇DCB应用于AMI的效果良好，可改善患者凝血功能，降低心血管事件和再闭塞率，值得临床应用。
Abstract:
Objective To investigate the efficacy of paclitaxel drug coated balloon (DCB) in the treatment of acute myocardial infarction (AMI) and its influence on postoperative coagulation status.Methods A total of 80 patients with AMI who underwent percutaneous coronary intervention (PCI) in our hospital from May 2020 to May 2021 were selected as the research subjects. They were divided into control group and observation group according to the random number table method, with 40 cases in each group. The control group was treated with drug-eluting stent (DES) during the operation, and the observation group was treated with paclitaxel DCB. The therapeutic effect, coagulation function indexes [prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and Fibrinogen(FIB)], incidence of cardiovascular events (MACE), recanalization rate and reocclusion rate were compared between the two groups.Results The total effective rate of the observation group was 97.50%, which was higher than 85.00% of the control group, and the difference was statistically significant (P<0.05). The levels of PT, APTT, TT and FIB in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The incidence of MACE in the observation group was 5.00%, which was lower than 20.00% in the control group, and the difference was statistically significant (P<0.05). The reocclusion rate of the observation group was 5.00%, which was lower than 22.50% of the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the recanalization rate between the two groups (P>0.05).Conclusion The effect of paclitaxel DCB in AMI is good, which can improve the coagulation function of patients, reduce cardiovascular events and reocclusion rate, and is worthy of clinical application.

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更新日期/Last Update: 1900-01-01