[1]李 丹,黄艳丹,卢 艳.GSDMs家族在子宫内膜癌中的表达情况和预后价值[J].医学信息,2023,36(03):63-69.[doi:10.3969/j.issn.1006-1959.2023.03.014]
　LI Dan,HUANG Yan-dan,LU Yan.The Expression and Prognostic Value of GSDMs Family in Uterine Corpus Endometrial Cancer[J].Journal of Medical Information,2023,36(03):63-69.[doi:10.3969/j.issn.1006-1959.2023.03.014]
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GSDMs家族在子宫内膜癌中的表达情况和预后价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年03期
页码:
63-69
栏目:
生物信息学
出版日期:
2023-02-01

文章信息/Info

Title:
The Expression and Prognostic Value of GSDMs Family in Uterine Corpus Endometrial Cancer
文章编号:
1006-1959（2023）03-0063-07
作者:
李 丹; 黄艳丹; 卢 艳
（广西医科大学附属肿瘤医院妇瘤科，广西 南宁 530021）
Author(s):
LI Dan; HUANG Yan-dan; LU Yan
(Department of Gynecologic Oncology,Guangxi Medical University Cancer Hospital,Nanning 530021,Guangxi,China)
关键词:
子宫内膜癌; Gasdermin家族; 免疫浸润; 生物信息学分析
Keywords:
Uterine corpus endometrial cancer; Gasdermin family; Immune infiltration; Bioinformatics analysis
分类号:
R737.33
DOI:
10.3969/j.issn.1006-1959.2023.03.014
文献标志码:
A
摘要:
目的 分析Gasdermins（GSDMs）家族在子宫内膜癌（UCEC）中的表达水平、作用机制及预后价值。方法 通过ULACAN和cBioportal数据库综合分析GSDMs在UCEC中的表达情况；Kaplan-Meier Plotter数据库预测其预后价值；Cytoscape和Metascape探索其功能机制；TISIDB、TIMER分析免疫浸润水平。结果 相较于正常内膜组织，子宫内膜癌组织中GSDMA、GSDMB、GSDMC、GSDMD表达升高，GSDME和PJVK基因表达降低，差异有统计学意义（P＜0.05），且GSDMB和DFNA5的表达与肿瘤分期有关；GSDMD低表达患者OS和RFS下降（P＜0.05），而其他基因表达量与患者OS、RFS未见明显相关性（P＞0.05）；GO和KEGG通路富集分析显示，GSDMs家族参与调控细胞分裂周期、泛素依赖性蛋白质代谢过程、内体膜、鞘脂信号通路和AMPK信号通路等；Cox比例风险回归模型分析显示，CD4+T细胞（HR=0.000，P=0.005）、CD8+T细胞（HR=0.001，P=0.001）、GSDMB（HR=1.216，P=0.028）、GSDMD（HR=0.674，P=0.016）和GSDME（HR=1.330，P=0.026）可能是UCEC的独立预后因素；GSDMA、GSDMB、GSDMD与PD-1呈正相关（P＜0.05）；PD-L1与GSDMA、GSDMC呈正相关，与PJVK呈负相关（P＜0.05）；GSDMA、GSDMB、GSDMD与CTLA4呈正相关（P＜0.05）。结论 GSDMs家族与子宫内膜癌的致病机制、预后价值、免疫浸润相关，是子宫内膜癌诊断标志物以及免疫治疗的潜在靶点。
Abstract:
Objective To analyze the expression level, mechanism and prognostic value of Gasdermins (GSDMs) family in uterine corpus endometrial carcinoma (UCEC).Methods The expression of GSDMs in UCEC was analyzed by ULACAN and cBioportal database. Kaplan-Meier Plotter database was used to predict its prognostic value. Cytoscape and Metascape explored its functional mechanism; tISIDB and TIMER were used to analyze the level of immune infiltration.Results Compared with normal endometrial tissues, the expression of GSDMA, GSDMB, GSDMC and GSDMD in endometrial cancer tissues increased, and the expression of GSDME and PJVK genes decreased, the difference was statistically significant (P<0.05), and the expression of GSDMB and DFNA5 was related to tumor stage ; the OS and RFS of patients with low expression of GSDMD decreased (P<0.05), while the expression of other genes was not significantly correlated with OS and RFS (P>0.05). GO and KEGG pathway enrichment analysis showed that the GSDMs family was involved in regulating cell division cycle, ubiquitin-dependent protein metabolism, endosomal membrane, sphingolipid signaling pathway and AMPK signaling pathway. Cox proportional hazard regression model analysis showed that CD4+T cells (HR=0.000, P=0.005), CD8+ T cells (HR=0.001, P=0.001), GSDMB (HR=1.216, P=0.028), GSDMD (HR=0.674, P=0.016) and GSDME (HR=1.330, P=0.026) may be independent prognostic factors of UCEC. GSDMA, GSDMB and GSDMD were positively correlated with PD-1 (P<0.05); PD-L1 was positively correlated with GSDMA and GSDMC, and negatively correlated with PJVK (P<0.05); GSDMA, GSDMB and GSDMD were positively correlated with CTLA4 (P<0.05).Conclusion The GSDMs family is related to the pathogenesis, prognostic value and immune infiltration of endometrial cancer, and is a potential target for diagnostic markers and immunotherapy of endometrial cancer.

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更新日期/Last Update: 1900-01-01