[1]宋澜澜,付文金.外泌体在糖尿病肾病中的作用机制[J].医学信息,2023,36(24):178-182.[doi:10.3969/j.issn.1006-1959.2023.24.042]
 SONG Lan-lan,FU Wen-jin.The Mechanism of Exosomes in Diabetic Nephropathy[J].Journal of Medical Information,2023,36(24):178-182.[doi:10.3969/j.issn.1006-1959.2023.24.042]
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外泌体在糖尿病肾病中的作用机制()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年24期
页码:
178-182
栏目:
综述
出版日期:
2023-12-15

文章信息/Info

Title:
The Mechanism of Exosomes in Diabetic Nephropathy
文章编号:
1006-1959(2023)24-0178-05
作者:
宋澜澜付文金
(1.广东医科大学研究生院,广东 湛江 524000;2.广东医科大学附属厚街人民医院检验科,广东 东莞 523945)
Author(s):
SONG Lan-lanFU Wen-jin
(1.Graduate School of Guangdong Medical University,Zhanjiang 524000,Guangdong,China;2.Laboratory of Houjie People’s Hospital Affiliated to Guangdong Medical University,Dongguan 523945,Guangdong,China)
关键词:
外泌体糖尿病肾病病理机制
Keywords:
ExosomesDiabetes nephropathyPathological mechanism
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2023.24.042
文献标志码:
A
摘要:
糖尿病肾病(DN)是2型糖尿病最常见的并发症,也是全球终末期肾病(ESRD)发生的主要原因之一。目前DN的发病机制尚未明确,对其机制的深入研究有利于疾病的早期诊断、严重性评估和针对性治疗。外泌体在细胞间通讯发挥重要作用,其含有特定细胞类型的核酸、蛋白质等生物活性分子,使其具有成为高度特异性和敏感性生物标志物的潜力。外泌体参与了DN发生发展,然而其病理机制尚未完全阐明,因此本综述重点关注外泌体在DN中的病理生理学机制,以期为DN的早期诊断和精准治疗提供新方向。
Abstract:
Diabetic nephropathy (DN) is the most common complication of type 2 diabetes mellitus and one of the leading causes of end-stage renal disease (ESRD) worldwide. At present, the pathogenesis of DN has not been clarified. In-depth study of the mechanism is conducive to early diagnosis, severity assessment and targeted treatment of the disease. Exosomes play an important role in cell-to-cell communication, containing specific cell types of nucleic acids, proteins and other biologically active molecules, making them have the potential to become highly specific and sensitive biomarkers. Exosomes are involved in the occurrence and development of DN, but its pathological mechanism has not been fully elucidated. Therefore, this review focuses on the pathophysiological mechanism of exosomes in DN, in order to provide a new direction for the early diagnosis and precise treatment of DN.

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更新日期/Last Update: 1900-01-01