[1]郝晓明,王玉杰.基于数据挖掘对前列腺癌预后有预测价值的差异基因筛选[J].医学信息,2024,37(01):16-21.[doi:10.3969/j.issn.1006-1959.2024.01.003]
　HAO Xiao-ming,WANG Yu-jie.Screening of Differentially Expressed Genes with Predictive Value for Prognosis of Prostate Cancer Based on Data Mining[J].Journal of Medical Information,2024,37(01):16-21.[doi:10.3969/j.issn.1006-1959.2024.01.003]
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基于数据挖掘对前列腺癌预后有预测价值的差异基因筛选()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年01期
页码:
16-21
栏目:
生物信息学
出版日期:
2024-01-01

文章信息/Info

Title:
Screening of Differentially Expressed Genes with Predictive Value for Prognosis of Prostate Cancer Based on Data Mining
文章编号:
1006-1959（2024）01-0016-06
作者:
郝晓明; 王玉杰
（新疆医科大学第一附属医院泌尿外科，新疆 乌鲁木齐 830054）
Author(s):
HAO Xiao-ming; WANG Yu-jie
(Department of Urinary Surgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China)
关键词:
前列腺癌; 预后; 总生存期; 差异基因; 筛选
Keywords:
Prostate cancer; Prognosis; Overall survival; Differentially expressed genes; Screening
分类号:
R737.25
DOI:
10.3969/j.issn.1006-1959.2024.01.003
文献标志码:
A
摘要:
目的 通过数据挖掘筛选对前列腺癌总生存期（OS）及无疾病生存期（DFS）有预测价值的差异基因。方法 通过挖掘GEPIA2数据库中与前列腺癌OS、DFS有关的基因以及肿瘤差异基因信息，探讨上调基因和下调基因与OS、DFS的关系，最后筛选出对前列腺癌OS及DFS有预测价值的差异基因。结果 共筛选出在前列腺癌差异表达的基因3005个，其中上调基因681个、下调基因2324个。与OS有关的基因497个，从中筛选出差异表达的基因63个，其中上调基因6个，下调基因57个，UBE2SP2、RP11-627G23.1、RPL7P23、TK1的上调和前列腺癌较低的OS有关，而RNA5-8S5和ELOVL2高表达的患者前列腺癌OS高于低表达的患者。与DFS有关的基因499个，从中筛选出差异基因184个，其中上调基因9个，C2、FUCA1、C9orf152表达上调的前列腺癌患者DFS较高，而TK1、CDC20、BIRC5、TOP2A、UBE2SP2、FAM223A高表达与较低的DFS有关，下调基因175个。UBE2SP2和TK1存在正相关，且高表达与较差的OS和DFS均有关。结论 本次共筛选出15个与前列腺癌预后有关的上调基因，可为对前列腺癌OS和DFS有预测价值的基因靶点选择提供一定参考。
Abstract:
Objective o screen the differentially expressed genes with predictive value for overall survival (OS) and disease-free survival (DFS) of prostate cancer by data mining.Methods By mining the information of genes related to OS and DFS of prostate cancer and tumor differentially expressed genes in the GEPIA2 database, the relationship between up-regulated genes and down-regulated genes and OS and DFS was explored. Finally, differentially expressed genes with predictive value for OS and DFS of prostate cancer were screened.Results A total of 3005 differentially expressed genes in prostate cancer were screened, including 681 up-regulated genes and 2324 down-regulated genes. There were 497 genes related to OS, and 63 differentially expressed genes were screened out, including 6 up-regulated genes and 57 down-regulated genes. The up-regulation of UBE2SP2, RP11-627G23.1, RPL7P23 and TK1 was related to the lower OS of prostate cancer, while the OS of prostate cancer in patients with high expression of RNA5-8S5 and ELOVL2 was higher than that in patients with low expression. There were 499 genes related to DFS, and 184 differentially expressed genes were screened out, including 9 up-regulated genes. The DFS of prostate cancer patients with up-regulated expression of C2, FUCA1 and C9orf152 was higher, while the high expression of TK1, CDC20, BIRC5, TOP2A, UBE2SP2 and FAM223A was related to lower DFS, and 175 genes were down-regulated. There was a positive correlation between UBE2SP2 and TK1, and high expression was associated with poor OS and DFS.Conclusion A total of 15 up-regulated genes related to the prognosis of prostate cancer are screened, which can provide some reference for the selection of gene targets with predictive value for OS and DFS of prostate cancer.

参考文献/References:

[1]Ye DW,Zhu Y.Prostate cancer and prostatic diseases Best of China,2018[J].Prostate Cancer Prostatic Dis,2019,22(1):1-2.[2]郑燕军,汪云兴,徐秀娟.血清炎性标志物与前列腺癌预后的关系研究[J].中国卫生检验杂志,2022,32(17):2115-2118,2122.[3]谢张兴,高亮,王晨,等.循环肿瘤细胞在前列腺癌诊断及预后中的临床应用[J].现代泌尿外科杂志,2022,27(7):609-613.[4]张泉波,李玉莲,陈绮,等.基于TCGA数据库构建前列腺癌相关miRNA预后模型[J].浙江医学,2021,43(18):1971-1978,2049-2050.[5]Attard G,Parker C,Eeles RA,et al.Prostate cancer[J].Lancet,2016,387(10013):70-82.[6]Jiang P,Chamberlain CS,Vanderby R,et al.TimeMeter assesses temporal gene expression similarity and identifies differentially progressing genes[J].Nucleic Acids Res,2020,48(9):e51.[7]汪逊,陆雪强,侯传胜,等.前列腺癌差异基因标志物筛选有助于预后评价[J].现代泌尿外科杂志,2022,27(6):512-518.[8]Grasso CS,Wu YM,Robinson DR,et al.The mutational landscape of lethal castration-resistant prostate cancer[J].Nature,2012,487(7406):239-243.[9]McCartney A,Malorni L.Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors[J].British Journal of Cancer,2020,123(2):176-177.[10]李雪菲,张丁丁,董丹丹,等.BIRC5高表达在胃癌中增强细胞活力、抑制凋亡并与预后不良相关[J].中国病理生理杂志,2020,36(11):2013-2019.[11]张九国,袁智勇.母胚亮氨酸拉链激酶(MELK)在肺腺癌中的表达及其与预后的相关性研究[J].国际生物医学工程杂志,2021,44(3):202-206.[12]楼威洋.假基因来源的RNA在肝癌发生和进展中的作用及其机制[D].杭州:浙江大学,2020.[13]Jeong D,Ham J,Kim HW,et al.ELOVL2: a novel tumor suppressor attenuating tamoxifen resistance in breast cancer[J].Am J Cancer Res,2021,11(6):2568-2589.[14]Hu T,Zhang H,Du Y,et al.ELOVL2 restrains cell proliferation, migration, and invasion of prostate cancer via regulation of the tumor suppressor INPP4B[J].Cell Signal,2022,96:110373.[15]Herrera H,Dilday T,Uber A,et al.Core-Fucosylated Tetra-Antennary N-Glycan Containing A Single N-Acetyllactosamine Branch Is Associated with Poor Survival Outcome in Breast Cancer[J].Int J Mol Sci,2019,20(10):2528.[16]Zhang C,Liu J,Chao F,et al.Alpha-L-Fucosidase Has Diagnostic Value in Prostate Cancer With "Gray-Zone PSA" and Inhibits Cancer Progression via Regulating Glycosylation[J].Front Oncol,2021,11:742354.[17]Wu X,Lv D,Eftekhar M,et al.A new risk stratification system of prostate cancer to identifyhigh-risk biochemical recurrence patients[J].Transl Androl Urol,2020,9(6):2572-2586.[18]石峰,孙文功,刘增振,等.CDC20基因的表达对前列腺癌患者临床病理特征及预后的影响[J].解放军医学杂志,2021,46(11):1092-1097.[19]葛新国,原小斌.细胞分裂周期蛋白20、微小RNA-34a-5p在膀胱尿路上皮癌组织中的表达及与临床病理的相关性[J].临床外科杂志,2021,29(11):1075-1078.[20]朱延杰,尤平洪,唐良友,等.miR-142-5p靶向调控TOP2A基因对前列腺癌细胞增殖和侵袭的影响[J].山东医药,2020,60(14):13-16.[21]Fu M,Wang Q,Wang H,et al.Immune-Related Genes Are Prognostic Markers for Prostate Cancer Recurrence[J].Front Genet,2021,12:639642. [22]郑浩然,蒋爱民,史楚楚,等.BIRC5基因在非小细胞肺癌中的表达及与免疫细胞浸润和预后的关系[J].现代肿瘤医学,2022,30(4):634-640.

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更新日期/Last Update: 1900-01-01