[1]李 龙,汪莲开.沙库巴曲缬沙坦在心力衰竭治疗中的应用[J].医学信息,2020,33(02):58-60.[doi:10.3969/j.issn.1006-1959.2020.02.016]
 LI Long,WANG Lian-kai.Application of Shakubatrivasartan in the Treatment of Heart Failure[J].Medical Information,2020,33(02):58-60.[doi:10.3969/j.issn.1006-1959.2020.02.016]
点击复制

沙库巴曲缬沙坦在心力衰竭治疗中的应用()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年02期
页码:
58-60
栏目:
综述
出版日期:
2020-01-15

文章信息/Info

Title:
Application of Shakubatrivasartan in the Treatment of Heart Failure
文章编号:
1006-1959(2020)02-0058-03
作者:
李 龙1汪莲开2
(1.湖北民族大学,湖北 恩施 445000;2.湖北民族大学附属民大医院心血管内科,湖北 恩施 445000)
Author(s):
LI Long1WANG Lian-kai2
(1.Hubei Minzu University,Enshi 445000,Hubei,China;2.Department of Internal Medicine-cardiovascular,Minda Hospital Affliated to Hubei Minzu University,Enshi 445000,Hubei,China)
关键词:
心力衰竭血管紧张素受体脑啡肽酶抑制剂沙库巴曲缬沙坦
Keywords:
Heart failureAngiotensin receptor enkephalinase inhibitorShakubatrivasartan
分类号:
R57
DOI:
10.3969/j.issn.1006-1959.2020.02.016
文献标志码:
A
摘要:
心力衰竭是一种慢性疾病,是心脏无法泵出足够的血液为其他身体器官提供氧气,从而引发呼吸短促、疲劳和水肿等症状。目前其治疗包括病因治疗、一般治疗、药物治疗及非药物治疗等,其中血管紧张素受体脑啡肽酶抑制剂(ARNI)是当前新研发出的一类抗心衰药物,沙库巴曲缬沙坦是其代表药物,具有阻断肾素-血管紧张-醛固酮系统(RAAS)及抑制脑啡肽酶(NEP)的双重作用,新的欧美指南均推荐用于射血分数降低心力衰竭(HFrEF)的治疗。本文现就沙库巴曲缬沙坦在心力衰竭治疗中的作用机理、临床试验、药物安全性作一综述,旨在为该病的临床治疗提供参考。
Abstract:
Heart failure is a chronic disease in which the heart cannot pump enough blood to provide oxygen to other body organs, which can cause shortness of breath, fatigue, and edema. At present, its treatment includes etiology treatment, general treatment, drug treatment, and non-drug treatment. Among them, angiotensin receptor enkephalinase inhibitor (ARNI) is a newly developed class of anti-heart failure drugs,Shakubatrivasartanis its representative drug. It has the dual effects of blocking the renin-angiotensin-aldosterone system (RAAS) and inhibiting enkephalinase (NEP). New European and American guidelines are recommended for ejection fraction. Treatment to reduce heart failure (HFrEF).This article reviews the mechanism, clinical trials, and drug safety of Shakubatrivasartan in the treatment of heart failure in order to provide a reference for the clinical treatment of the disease.

参考文献/References:

[1]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志,2014,42(2):98-122. [2]Benjamin EJ,Blaha MJ,Chiuve SE,et al.Heart Disease and Stroke Statistics-2017 Update:A Report From the American Heart Association[J].Circulation,2017,135(10):e196. [3]Yancy CW,Jessup M,Bozkurt B,et al.2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure:A Report of the American College of CardiologyAmerican Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America[J].J Am Coll Cardiol,2017,70(6):776-803. [4]中华医学会心血管病学分会心力衰竭学组,中国医师协会心力衰竭专业委员会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2018[J].中华心血管病杂志,2018,46(10):760-789. [5]Tanai E,Frantz S.Pathophysiology of Heart Failure[J].Compr Physiol,2015,6(1):187-214. [6]Mollace V,Gliozzi M,Capuano A,et al.Modulation of RAAS-natriuretic peptides in the treatment of HF:Old guys and newcomers[J].Int J Cardiol,2017(226):126-131. [7]Ghazi L,Drawz P.Advances in understanding the renin-angiotensin-aldosterone system(RAAS)in blood pressure control and recent pivotal trials of RAAS blockade in heart failure and diabetic nephropathy[J].F1000Res,2017(6):F1000. [8]Polhemus DJ,Trivedi RK,Gao J,et al.Renal Sympathetic Denervation Protects the Failing Heart Via Inhibition of Neprilysin Activity in the Kidney[J].J Am Coll Cardiol,2017,70(17):2139-2153. [9]Bayes-Genis A,Barallat J,Galan A,et al.Soluble neprilysin is predictive of cardiovascular death and heart failure hospitalization in heart failure patients[J].J Am Coll Cardiol,2015,65(7):657-665. [10]Senni M,McMurray JJ,Wachter R,et al.Initiating sacubitril/valsartan(LCZ696)in heart failure: results of TITRATION,a double-blind,randomized comparison of two uptitration regimens[J].Eur J Heart Fail,2016,18(9):1193-1202. [11]Solomon SD,Zile M,Pieske B,et al.The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction:a phase 2 double-blind randomised controlled trial[J].The Lancet,2012,380(9851):1387-1395. [12]McMurray JJ,Packer M,Desai AS,et al.Angiotensin-neprilysin inhibition versus enalapril in heart failure[J].N Engl J Med,2014,371(11):993-1004. [13]崔晓通,周京敏,葛均波.PARADIGM-HF研究结果解读[J].中国循环杂志,2018,33(2):203-205. [14]Yancy CW,Jessup M,Bozkurt B,et al.2016 ACC/AHA/HFSA Focused Update on New Pharmacological Therapy for Heart Failure:An Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure:A Report of the American College of CardiologyAmerican Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America[J].J Am Coll Cardiol,2016,68(13):1476-1488. [15]Pascual-Figal D,Wachter R,Senni M,et al.Rationale and design of TRANSITION:a randomized trial of pre-discharge vs.post-discharge initiation of sacubitril/valsartan[J].ESC Heart Fail,2018,5(2):327-336. [16]Velazquez EJ,Morrow DA,DeVore AD,et al.Angiotensin-Neprilysin Inhibition in Acute Decompensated Heart Failure[J].N Engl J Med,2019,380(6):539-548. [17]Mogensen UM,K?ber L,Kristensen SL,et al.The effects of sacubitril/valsartan on coronary outcomes in PARADIGM-HF[J].Am Heart J,2017(188):35-41. [18]Bohm M,Young R,Jhund PS,et al.Systolic blood pressure,cardiovascular outcomes and efficacy and safety of sacubitril/valsartan(LCZ696)in patients with chronic heart failure and reduced ejection fraction:results from PARADIGM-HF[J].Eur Heart J,2017,38(15):1132-1143. [19]Jhund PS,Fu M,Bayram E,et al.Efficacy and safety of LCZ696(sacubitril-valsartan)according to age:insights from PARADIGM-HF[J].European Heart Journal,2015,36(38):2576-2584. [20]Desai AS,Vardeny O,Claggett B,et al.Reduced Risk of Hyperkalemia During Treatment of Heart Failure With Mineralocorticoid Receptor Antagonists by Use of Sacubitril/Valsartan Compared With Enalapril:A Secondary Analysis of the PARADIGM-HF Trial[J].JAMA Cardiol,2017,2(1):79-85. [21]Tyler JM,Teerlink JR.The safety of sacubitril-valsartan for the treatment of chronic heart failure[J].Expert Opinion on Drug Safety,2017,16(2):257. [22]Han Y,Ayalasomayajula S,Pan W,et al.Pharmacokinetics,Safety and Tolerability of Sacubitril/Valsartan(LCZ696)After Single-Dose Administration in Healthy Chinese Subjects[J].Eur J Drug Metab Pharmacokinet,2017,42(1):109-116.

相似文献/References:

[1]郭俊林,张立.BNP对CRT后期疗效的临床评价[J].医学信息,2018,31(01):67.[doi:10.3969/j.issn.1006-1959.2018.01.024]
 GUO Jun-lin,ZHANG li.Clinical Evaluation of BNP in Treatment of Late CRT[J].Medical Information,2018,31(02):67.[doi:10.3969/j.issn.1006-1959.2018.01.024]
[2]程 林.重组人脑利钠肽用于重症急性心肌炎伴 心力衰竭患者治疗的临床研究[J].医学信息,2018,31(08):126.[doi:10.3969/j.issn.1006-1959.2018.08.042]
 CHENG Lin.Clinical Study of Recombinant Human Brain Natriuretic Peptide in the Treatment of Patients with Severe Acute Myocarditis and Heart Failure[J].Medical Information,2018,31(02):126.[doi:10.3969/j.issn.1006-1959.2018.08.042]
[3]胡丽君.螺内酯联合曲美他嗪治疗慢性心力衰竭的疗效分析[J].医学信息,2018,31(08):131.[doi:10.3969/j.issn.1006-1959.2018.08.044]
 HU Li-jun.Efficacy of Spironolactone Combined with Trimetazidine in the Treatment of Chronic Heart Failure[J].Medical Information,2018,31(02):131.[doi:10.3969/j.issn.1006-1959.2018.08.044]
[4]李 铎,王建华.盐酸曲美他嗪片辅助治疗对冠心病伴心力衰竭患者氧化应激、心肌功能的影响[J].医学信息,2018,31(10):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
 LI Duo,WANG Jian-hua.Effect of Trimetazidine Hydrochloride Tablets Adjuvant Therapy on Oxidative Stress and Myocardial Function in Patients with Coronary Heart Disease Complicated with Heart Failure[J].Medical Information,2018,31(02):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
[5]平兰芝,黄小楼,胡天俊,等.CaMKⅡ在心血管疾病中的研究[J].医学信息,2022,35(10):59.[doi:10.3969/j.issn.1006-1959.2022.10.014]
 PING Lan-zhi,HUANG Xiao-lou,HU Tian-jun,et al.Research on the Role of CaMKⅡ in Cardiovascular Diseases[J].Medical Information,2022,35(02):59.[doi:10.3969/j.issn.1006-1959.2022.10.014]
[6]刘革铭,马洪俊,刘 毅,等.心力衰竭的机制及诊疗的研究[J].医学信息,2022,35(10):91.[doi:10.3969/j.issn.1006-1959.2022.10.022]
 LIU Ge-ming,MA Hong-jun,LIU Yi,et al.Mechanism, Diagnosis and Treatment of Heart Failure[J].Medical Information,2022,35(02):91.[doi:10.3969/j.issn.1006-1959.2022.10.022]
[7]黄光明,赵兴昌,符显昭.水中运动联合中药内治对糖尿病大鼠心肌细胞凋亡和心功能的影响[J].医学信息,2022,35(11):72.[doi:10.3969/j.issn.1006-1959.2022.11.020]
 HUANG Guang-ming,ZHAO Xing-chang,FU Xian-zhao.Effects of Aquatic Therapeutic Exercise Combined with Traditional Chinese Medicine Internal Treatment on Cardiomyocyte Apoptosis and Cardiac Function in Diabetic Rats[J].Medical Information,2022,35(02):72.[doi:10.3969/j.issn.1006-1959.2022.11.020]
[8]何玲玲,程淑芬.曲美他嗪联合琥珀酸美托洛尔治疗冠心病心力衰竭疗效观察[J].医学信息,2018,31(13):142.[doi:10.3969/j.issn.1006-1959.2018.13.042]
 HE Ling-ling,CHENG Shu-fen.Therapeutic Effect of Trimetazidine Combined with Metoprolol Succinate in the Treatment of Coronary Heart Disease with Heart Failure[J].Medical Information,2018,31(02):142.[doi:10.3969/j.issn.1006-1959.2018.13.042]
[9]赵 维,廖荣宏,王爱华.糖皮质激素治疗心力衰竭疗效与安全性的Meta分析[J].医学信息,2018,31(14):70.[doi:10.3969/j.issn.1006-1959.2018.14.021]
 ZHAO Wei,LIAO Rong-hong,WANG Ai-hua.Meta-analysis of the Efficacy and Safety of Glucocorticoids in the Treatment of Heart Failure[J].Medical Information,2018,31(02):70.[doi:10.3969/j.issn.1006-1959.2018.14.021]
[10]施国富,吴春阳,施亚明,等.血浆脑钠肽对射血分数保留心力衰竭患者的诊断价值研究[J].医学信息,2018,31(16):47.[doi:10.3969/j.issn.1006-1959.2018.16.013]
 SHI Guo-fu,WU Chun-yang,SHI Ya-ming,et al.Diagnostic Value of Plasma Brain Natriuretic Peptide in Patients with Heart Failure Preserved by Ejection Fraction[J].Medical Information,2018,31(02):47.[doi:10.3969/j.issn.1006-1959.2018.16.013]
[11]韦怡春,易秋艳.沙库巴曲缬沙坦对心力衰竭患者抑郁的影响[J].医学信息,2021,34(23):29.[doi:10.3969/j.issn.1006-1959.2021.23.008]
 WEI Yi-chun,YI Qiu-yan.Effect of Sacubitril Valsartan on Depression in Patients with Heart Failure[J].Medical Information,2021,34(02):29.[doi:10.3969/j.issn.1006-1959.2021.23.008]

更新日期/Last Update: 2020-01-15