[1]刘廷胜.氯吡格雷联合阿司匹林治疗急性心肌梗死的研究[J].医学信息,2020,33(06):59-61.[doi:10.3969/j.issn.1006-1959.2020.06.018]
　LIU Ting-sheng.A Study of Clopidogrel Combined with Aspirin in the Treatment of Acute Myocardial Infarction[J].Medical Information,2020,33(06):59-61.[doi:10.3969/j.issn.1006-1959.2020.06.018]
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氯吡格雷联合阿司匹林治疗急性心肌梗死的研究()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年06期
页码:
59-61
栏目:
综述
出版日期:
2020-03-15

文章信息/Info

Title:
A Study of Clopidogrel Combined with Aspirin in the Treatment of Acute Myocardial Infarction
文章编号:
1006-1959（2020）06-0059-03
作者:
刘廷胜
（天津市蓟州区中医医院内科，天津 301900）
Author(s):
LIU Ting-sheng
(Department of Internal Medicine,Jizhou District Traditional Chinese Medicine Hospital,Tianjin 301900,China)
关键词:
急性心肌梗死; 氯吡格雷; 阿司匹林
Keywords:
Acute myocardial infarction; Clopidogrel; Aspirin
分类号:
K542.2+2
DOI:
10.3969/j.issn.1006-1959.2020.06.018
文献标志码:
A
摘要:
急性心肌梗死（AMI）属于冠心病最严重类型，其指冠状动脉突发性闭塞，造成心肌缺血、损伤或坏死性疾病。该病病理基础多为冠状动脉粥样硬化、冠状动脉痉挛，易导致血栓形成，阻塞血管，具有较高病死率及致残率，现已成为临床研究重点。血小板聚集在该疾病发展中具有重要作用，而抗血栓及抗血小板治疗可有效预防血栓形成，降低AMI发生率。氯吡格雷与阿司匹林均属于抗血栓类药物，可有效阻滞血小板聚集，预防血栓形成，现被临床广泛应用于心脑血管疾病治疗中。本文就氯吡格雷和阿司匹林作用机制、治疗AMI的临床价值、不良反应作一综述，以期为临床用药提供参考。
Abstract:
Acute myocardial infarction (AMI) is the most severe type of coronary heart disease, which refers to sudden occlusion of coronary arteries, causing myocardial ischemia, injury or necrotic disease. The pathological basis of the disease is mostly coronary atherosclerosis and coronary spasm, which easily lead to thrombosis and block blood vessels. It has a high mortality and disability rate, and has become the focus of clinical research. Platelet aggregation plays an important role in the development of the disease, and antithrombotic and antiplatelet therapy can effectively prevent thrombosis and reduce the incidence of AMI. Both clopidogrel and aspirin are antithrombotic drugs that can effectively block platelet aggregation and prevent thrombosis. They are now widely used in the treatment of cardiovascular and cerebrovascular diseases. This article reviews the mechanism of action of clopidogrel and aspirin, its clinical value in treating AMI, and adverse reactions in order to provide a reference for clinical use.

参考文献/References:

[1]韩安邦,张健,路迎冬,等.芪苈强心胶囊对心肌梗死大鼠心肌纤维化及TGF-β1/Smad3信号通路的影响[J].北京中医药大学学报,2017,40(1):41-47.[2]黄震华.急性ST段抬高型心肌梗死溶栓治疗后经皮冠状动脉介入治疗的必要性和时机[J].中国新药与临床杂志,2016,35(1):18-23.[3]刘晓刚,胡立群,刘玉峰,等.替格瑞洛与氯吡格雷对急性非ST段抬高型心肌梗死患者经皮冠状动脉介入术后炎症因子的影响[J].中国临床药理学杂志,2016,32(9):789-791.[4]梁茜茜,张庆,李莉,等.阿司匹林联合氯吡格雷治疗急性脑梗死的临床研究[J].中国临床药理学杂志,2016,23(16):1446-1448,1467.[5]贾珠银,杨建敏.替格瑞洛联合阿司匹林治疗急性冠状动脉综合征的临床研究[J].中国临床药理学杂志,2016,32(14):1254-1256.[6]陈璐菡,潘涛.辛伐他汀联合阿司匹林治疗脑血栓的效果及对神经功能缺损的影响[J].中国医药导报,2016,13(23):161-164.[7]霍志军,王金鑫,王瑞雪,等.阿司匹林抗血小板聚集的监测和机制研究[J].世界临床药物,2016,37(2):124-128.[8]梁茜,张健瑜,杨希立,等.急性冠脉综合征合并糖尿病患者经皮冠脉介入术后替格瑞洛与氯吡格雷的疗效比较[J].中国医科大学学报,2016,45(2):145-149.[9]周伟伟,谷惠敏,吕晓蕾,等.氯吡格雷联合阿司匹林治疗老年急性心肌梗死的疗效分析[J].河北医药,2018,40(14):107-109,113.[10]侯晓玲,李雅.氯吡格雷联合阿司匹林治疗急性心肌梗死对临床疗效心功能及预后观察[J].山西医药杂志,2019,48(10):47-49.[11]张晓峰,刘刚,张君红,等.阿司匹林联合氯吡格雷对急性心肌梗死急诊经皮冠脉介入治疗术后心功能影响[J].药物评价研究,2018,41(8):111-114.[12]赵向辉.氯吡格雷、阿司匹林合并应用于急性心肌梗死临床治疗的血管再通率分析[J].中国医药导刊,2017,19(1):71-72.[13]金朝霞,万里鹏,覃艳琼.氯吡格雷联合阿司匹林治疗急性心肌梗死的临床效果[J].心血管康复医学杂志,2018,27(5):66-69.[14]郭仕俊,苏令,章福彬,等.氯吡格雷联合肠溶性阿司匹林在急性心肌梗死治疗中的应用[J].蚌埠医学院学报,2017,42(4):458-461.[15]顾潇.阿司匹林与氯吡格雷在急性心肌梗死行经皮介入术后对凝血功能的影响[J].血栓与止血学,2019,25(1):63-64.[16]Sun YB,Tao Y,Yang M.Assessing the influence of acute kidney injury on the mortality in patients with acute myocardial infarction:a clinical trail[J].Ren Fail,2018,40(1):75-84.[17]刘培英,梁雪梅,田明秀.氯吡格雷联合阿司匹林治疗短暂性脑缺血62例[J].医药导报,2015,34(3):329-331.[18]左凤同,刘辉,吴慧君,等.阿司匹林联合氯吡格雷治疗伴有血管狭窄的脑梗死的临床观察[J].现代生物医学进展,2015,15(31):6104-6106.[19]Smilowitz NR,Gupta N,Guo Y,et al.Perioperative acute myocardial infarction associated with non-cardiac surgery[J].Eur Heart J,2017,38(31):2409-2417.[20]常冠楠,苏曼侠.氯吡格雷联合阿司匹林对老年不稳定性心绞痛患者血小板聚集的影响[J].中华老年心脑血管病杂志,2016,18(1):85-86.[21]崔政,胡雪婷.阿司匹林联合小剂量氯吡格雷对高龄脑梗死患者神经功能的影响[J].实用临床医药杂志,2019,23(10):25-28.[22]方亚平.长期使用小剂量阿司匹林对胃十二指肠粘膜损伤的内镜观察[C]//第八届国际治疗内镜和消化疾病学术会议. 2006.[23]张绍深.阿司匹林与氯吡格雷消化道不良反应的临床分析[J].临床合理用药杂志,2010,3(16):81-82.

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更新日期/Last Update: 2020-03-15