[1]于易琼,李 秀.血嗜酸性粒细胞及血尿酸在频繁急性加重表型慢性阻塞性肺疾病患者中的表达特征[J].医学信息,2022,35(02):6-9.[doi:10.3969/j.issn.1006-1959.2022.02.002]
　YU Yi-qiong,LI Xiu.Expression Characteristics of Blood Eosinophils and Serum Uric Acid in Patientswith Frequent Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J].Medical Information,2022,35(02):6-9.[doi:10.3969/j.issn.1006-1959.2022.02.002]
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血嗜酸性粒细胞及血尿酸在频繁急性加重表型慢性阻塞性肺疾病患者中的表达特征()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年02期
页码:
6-9
栏目:
出版日期:
2022-01-15

文章信息/Info

Title:
Expression Characteristics of Blood Eosinophils and Serum Uric Acid in Patientswith Frequent Acute Exacerbation of Chronic Obstructive Pulmonary Disease
文章编号:
1006-1959（2022）02-0006-04
作者:
于易琼; 李 秀
安徽医科大学第三附属医院/合肥市第一人民医院呼吸与危重症医学科，安徽 合肥 230061
Author(s):
YU Yi-qiong; LI Xiu
Department of Respiratory and Critical Care Medicine,the Third Affiliated Hospital of Anhui Medical University/Hefei First people’s Hospital,Hefei 230061,Anhui,China
关键词:
慢性阻塞性肺疾病; 肺功能; 嗜酸性粒细胞
Keywords:
Chronic obstructive pulmonary disease; Lung function; Eosinophil
分类号:
R562
DOI:
10.3969/j.issn.1006-1959.2022.02.002
文献标志码:
A
摘要:
目的 探讨血嗜酸性粒细胞及血尿酸在频繁急性加重表型慢性阻塞性肺疾病（COPD）患者中的表达特征。方法 选取2020年4月-2021年4月我院收治的稳定期COPD患者123例，以过去12个月急性加重次数是否≥2次分为频繁急性加重组与对照组。比较两组临床资料，并采用二元多因素Logistic回归分析COPD患者频繁急性加重的危险因素。结果 两组性别、年龄、体重指数、吸烟史、白细胞计数、中性粒细胞计数、中性粒细胞百分比比较，差异无统计学意义（P＞0.05）；频繁急性加重组FEV1、FVC、FEV1/FVC、FEV1%pred、EOS%、血尿酸水平均低于对照组，CAT评分高于对照组，差异有统计学意义（P＜0.05）；二元多因素Logistic回归分析显示，EOS%、血尿酸、CAT评分为COPD患者频繁急性加重的独立危险因素（P＜0.05）。结论 低水平EOS%、低水平血尿酸、高CAT评分是COPD患者频繁急性加重的独立危险因素，早期识别此类患者，并给予相关干预措施，可减少频繁急性加重事件的发生。
Abstract:
Objective To investigate the expression characteristics of blood eosinophils and serum uric acid in patients with frequent acute exacerbation of chronic obstructive pulmonary disease (COPD).Methods A total of 123 patients with stable COPD admitted to our hospital from April 2020 to April 2021 were selected and divided into frequent acute addition and recombination group and control group according to whether the number of acute exacerbations in the past 12 months was ≥2 times. The clinical data of the two groups were compared, and the risk factors of frequent acute exacerbation of COPD were analyzed by binary multivariate Logistic regression.Results There was no significant difference in gender, age, body mass index, smoking history, white blood cell count, neutrophil count and neutrophil percentage between the two groups (P>0.05). The levels of FEV1, FVC, FEV1/FVC, FEV1% pred, EOS% and serum uric acid in the frequent acute addition group were lower than those in the control group, and the CAT score was higher than that in the control group, the difference was statistically significant (P<0.05). Binary multivariate Logistic regression analysis showed that EOS%, serum uric acid and CAT score were independent risk factors for frequent acute exacerbation of COPD patients (P<0.05).Conclusion Low level of serum EOS%, low level of serum uric acid and high CAT score are risk factors for frequent acute exacerbations of COPD，early identification of such patients and related interventions can reduce the occurrence of acute exacerbation.

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更新日期/Last Update: 1900-01-01