[1]陈艳玲.内镜下止血术联合奥曲肽治疗上消化道出血的临床效果[J].医学信息,2022,35(11):141-143.[doi:10.3969/j.issn.1006-1959.2022.11.037]
　CHEN Yan-ling.Clinical Effect of Endoscopic Hemostasis Combined with Octreotide in the Treatment of Upper Gastrointestinal Bleeding[J].Medical Information,2022,35(11):141-143.[doi:10.3969/j.issn.1006-1959.2022.11.037]
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内镜下止血术联合奥曲肽治疗上消化道出血的临床效果()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年11期
页码:
141-143
栏目:
论著
出版日期:
2022-06-01

文章信息/Info

Title:
Clinical Effect of Endoscopic Hemostasis Combined with Octreotide in the Treatment of Upper Gastrointestinal Bleeding
文章编号:
1006-1959（2022）11-0141-03
作者:
陈艳玲
（沈阳市浑南区医院内科，辽宁 沈阳 110180）
Author(s):
CHEN Yan-ling
(Department of Internal Medicine,Hunnan District Hospital,Shenyang 110180,Liaoning,China)
关键词:
上消化道出血; 内镜止血术; 奥曲肽; 炎性反应; 氧化应激
Keywords:
Upper gastrointestinal bleeding; Endoscopic hemostasis; Octreotide; Inflammatory response; Oxidative stress
分类号:
R573.1；R573.3
DOI:
10.3969/j.issn.1006-1959.2022.11.037
文献标志码:
A
摘要:
目的 探究内镜下止血术联合奥曲肽治疗上消化道出血的临床效果。方法 选取2020年6月-2021年6月沈阳市浑南区医院内科收治的84例上消化道出血患者，按照随机数字表法分为对照组和观察组，各42例。对照组应用内镜下止血术治疗，观察组采用内镜下止血术联合奥曲肽治疗。比较两组临床疗效、止血情况、炎症反应指标[白细胞介素（IL-6、IL-17、IL-23）]、氧化应激指标[丙二醛（MDA） 、脂质过氧化氢（LHP）、超氧化物歧化酶（SOD）]。结果 观察组治疗有效率高于对照组，差异有统计学意义（P＜0.05）；观察组24 h止血率高于对照组，呕血消失时间短于对照组，差异有统计学意义（P＜0.05）；两组IL-6、IL-17、IL-23水平低于治疗前，且观察组对于对照组，差异有统计学意义（P＜0.05）；两组MDA、LHP指标低于治疗前，SOD高于治疗前，且观察组MDA、LHP低于对照组，SOD高于对照组，差异有统计学意义（P＜0.05）。结论 内镜止血术联合奥曲肽治疗上消化道出血效果显著，其止血效率高，可下调体内炎性因子，同时抑制氧化应激反应。
Abstract:
Objective To explore the clinical effect of endoscopic hemostasis combined with octreotide in the treatment of upper gastrointestinal bleeding.Methods A total of 84 patients with upper gastrointestinal bleeding admitted to Hunnan District Hospital of Shenyang from June 2020 to June 2021 were selected and divided into control group and observation group according to random number table method, with 42 cases in each group. The control group was treated with endoscopic hemostasis, and the observation group was treated with endoscopic hemostasis combined with octreotide. The clinical efficacy, hemostasis, inflammatory response indexes [interleukin (IL-6, IL-17, IL-23)], oxidative stress indexes [malondialdehyde (MDA), lipid hydrogen peroxide (LHP), and superoxide dismutase (SOD)] were compared between the two groups.Results The effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The 24 h hemostasis rate of the observation group was higher than that of the control group, and the disappearance time of hematemesis was shorter than that of the control group, the difference was statistically significant (P<0.05). The levels of IL-6, IL-17 and IL-23 in the two groups were lower than those before treatment, and the difference in the observation group was statistically significant for the control group (P<0.05). MDA and LHP in the two groups were lower than those before treatment, SOD was higher than that before treatment, and MDA and LHP in the observation group were lower than those in the control group, SOD was higher than that in the control group, the difference was statistically significant (P<0.05).Conclusion Endoscopic hemostasis combined with octreotide is effective in the treatment of upper gastrointestinal bleeding, with high hemostasis efficiency, which can down-regulate inflammatory factors and inhibit oxidative stress.

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更新日期/Last Update: 1900-01-01