[1]刘 楠.阿司匹林联合氯吡格雷双抗血小板治疗脑梗死的疗效观察及对血清hs-CRP及D-D水平的影响[J].医学信息,2022,35(19):82-84.[doi:10.3969/j.issn.1006-1959.2022.19.022]
　LIU Nan.The Effect of Aspirin Combined with Clopidogrel Dual Antiplatelet Therapy on Cerebral Infarction and its Effect on Serum hs-CRP and D-D Levels[J].Journal of Medical Information,2022,35(19):82-84.[doi:10.3969/j.issn.1006-1959.2022.19.022]
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阿司匹林联合氯吡格雷双抗血小板治疗脑梗死的疗效观察及对血清hs-CRP及D-D水平的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年19期
页码:
82-84
栏目:
论著
出版日期:
2022-10-01

文章信息/Info

Title:
The Effect of Aspirin Combined with Clopidogrel Dual Antiplatelet Therapy on Cerebral Infarction and its Effect on Serum hs-CRP and D-D Levels
文章编号:
1006-1959（2022）19-0082-03
作者:
刘 楠
（佳木斯市中心医院神经内一科，黑龙江 佳木斯 154002）
Author(s):
LIU Nan
(Department of Neurology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
阿司匹林; 氯吡格雷; 双抗; 脑梗死; hs-CRP; D-二聚体
Keywords:
Aspirin; Clopidogrel; Double antibody; Cerebral infarction; hs-CRP; D-dimer
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2022.19.022
文献标志码:
A
摘要:
目的 观察阿司匹林联合氯吡格雷双抗血小板治疗脑梗死的疗效及对血清hs-CRP及D-D水平的影响。方法 选择2018年1月-2021年7月我院诊治的67例脑梗死患者，采用随机数字表法分为对照组（n=34）和观察组（n=33）。对照组采用阿司匹林肠溶片治疗，观察组在对对照组基础上给予氯吡格雷治疗。比较两组临床总有效率、神经功能缺损评分、简易智力（MMSE）评分、日常生活能力评分、凝血功能指标、血清超敏-C反应蛋白（hs-CRP）、D-二聚体（D-D）水平以及临床不良反应发生率。结果 观察组治疗总有效率为93.93%，高于对照组的82.35%（P＜0.05）；两组治疗后神经功能缺损评分均低于治疗前，日常生活能力、MMSE评分均高于对照组，且观察组神经功能缺损评分低于对照组，日常生活能力、MMSE评分高于对照组（P＜0.05）；两组治疗后血浆凝血酶原时间（PT）、活化部分凝血活酶原时间（aPTT）均大于治疗前，纤维蛋白原（FIB）小于治疗前，且观察组PT、aPTT均大于对照组，FIB小于对照组（P＜0.05）；两组治疗后hs-CRP、D-D均低于治疗前，且观察组低于对照组（P＜0.05）；观察组不良反应发生率为6.06%，与对照组的8.82%比较，差异无统计学意义（P＞0.05）。结论 阿司匹林联合氯吡格雷双抗血小板治疗脑梗死效果确切，可提高治疗效果，改善凝血功能，降低神经功能缺损评分，提升日常生活能力和智力水平以及炎性因子指标，且无严重不良反应，具有良好的治疗有效性和安全性。
Abstract:
Objective To observe the effect of aspirin combined with clopidogrel dual antiplatelet therapy on cerebral infarction and its effect on serum hs-CRP and D-D levels.Methods A total of 67 patients with cerebral infarction diagnosed and treated in our hospital from January 2018 to July 2021 were selected and divided into control group (n=34) and observation group (n=33) by random number table method. The control group was treated with aspirin enteric-coated tablets, and the observation group was treated with clopidogrel on the basis of the control group. The total clinical effective rate, neurological deficit score, simple intelligence (MMSE) score, daily living ability score, coagulation function index, serum high-sensitivity C-reactive protein (hs-CRP), D-dimer (D-D) level and incidence of clinical adverse reactions were compared between the two groups.Results The total effective rate in observation group was 93.93%, which was higher than 82.35% in control group (P<0.05). After treatment, the neurological deficit scores of the two groups were lower than those before treatment, and the daily living ability and MMSE scores were higher than those of the control group, while the neurological deficit score of the observation group was lower than that of the control group, and the daily living ability and MMSE score were higher than those of the control group (P<0.05). After treatment, the plasma prothrombin time (PT) and activated partial thromboplastin time (aPTT) in the two groups were higher than those before treatment, and the fibrinogen (FIB) was lower than that before treatment, while the PT and aPTT in the observation group were higher than those in the control group, and FIB was lower than that in the control group (P<0.05). After treatment, hs-CRP and D-D in the two groups were lower than those before treatment, and the observation group was lower than the control group (P<0.05). The incidence of adverse reactions in the observation group was 6.06%, which was compared with 8.82% in the control group, the difference was not statistically significant (P>0.05).Conclusion Aspirin combined with clopidogrel dual antiplatelet therapy is effective in the treatment of cerebral infarction, which can improve the therapeutic effect, improve coagulation function, reduce neurological deficit score, improve daily living ability and intelligence level and inflammatory factor index, and has no significant adverse reactions. It has good therapeutic effectiveness and safety.

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更新日期/Last Update: 1900-01-01