[1]许凤姣.凝血功能检验在心脑血管疾病患者预后评估中的价值[J].医学信息,2023,36(11):138-141.[doi:10.3969/j.issn.1006-1959.2023.11.028]
　XU Feng-jiao.Value of Coagulation Function Test in the Prognosis Evaluation of Patients with Cardiovascular and Cerebrovascular Diseases[J].Journal of Medical Information,2023,36(11):138-141.[doi:10.3969/j.issn.1006-1959.2023.11.028]
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凝血功能检验在心脑血管疾病患者预后评估中的价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年11期
页码:
138-141
栏目:
诊疗技术
出版日期:
2023-06-01

文章信息/Info

Title:
Value of Coagulation Function Test in the Prognosis Evaluation of Patients with Cardiovascular and Cerebrovascular Diseases
文章编号:
1006-1959（2023）11-0138-04
作者:
许凤姣
（宜兴市中医医院检验科，江苏 宜兴 214200）
Author(s):
XU Feng-jiao
(Department of Laboratory Medicine,Yixing Hospital of Traditional Chinese Medicine,Yixing 214200,Jiangsu,China)
关键词:
凝血功能; 心脑血管疾病; 预后
Keywords:
Coagulation function; Cardiovascular and cerebrovascular diseases; Prognosis
分类号:
R743；R543
DOI:
10.3969/j.issn.1006-1959.2023.11.028
文献标志码:
A
摘要:
目的 研究凝血功能检验在心脑血管疾病患者预后中的判断价值。方法 回顾性分析2021年6月-2022年6月我院诊治的100例心脑血管疾病患者设为观察组，另选取同期在我院体检健康者100例设为对照组，均进行凝血功能检验[活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）、血浆凝血酶原时间（PT）、血浆凝血酶时间（TT）、D-二聚体（D-D）、抗凝血酶-Ⅲ（AT-Ⅲ）]，比较两组凝血功能各指标水平、不同预后患者凝血功能各指标水平。同时依据凝血功能指标异常情况，将观察组患者分为研究A组（＜3个指标比正常值增加或降低＜30%）和研究B组（≥3个指标低于或高于正常值30%），观察两组患者不同时间点凝血功能各指标水平及预后情况。结果 观察组APTT、PT、TT、D-D高于对照组，AT-Ⅲ、FIB低于对照组（P＜0.05）；预后良好者APTT、PT、TT、D-D低于病残者，AT-Ⅲ、FIB高于病残者（P＜0.05）；入院时及出血6、24 h，研究A组APTT、TT、FIB与研究B组比较，差异无统计学意义（P＞0.05）；而出血6、24 h，研究A组PT、AT-Ⅲ高于研究B组，D-D低于研究B组（P＜0.05）；研究A组致残、致死率均低于研究B组，良好率高于研究B组（P＜0.05）。结论 凝血功能检验在心脑血管疾病患者预后中具有重要的价值，心血管疾病患者均存在凝血功能异常，且预后较差。同时凝血功能指标异常情况越严重，患者出血风险越大，尤其是PT、D-D、AT-Ⅲ指标变化对出血风险具有一定的预测价值。
Abstract:
Objective To study the prognostic value of coagulation function test in patients with cardiovascular and cerebrovascular diseases. Methods A retrospective analysis of 100 patients with cardiovascular and cerebrovascular diseases diagnosed and treated in our hospital from June 2021 to June 2022 was set as the observation group, and 100 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. Coagulation function tests [activated partial thromboplastin time (APTT), fibrinogen (FIB), plasma prothrombin time (PT), plasma thrombin time (TT), D-dimer (D-D), antithrombin-Ⅲ (AT-Ⅲ)] were performed. The levels of coagulation function indexes and coagulation function indexes in patients with different prognosis were compared between the two groups. At the same time, according to the abnormal situation of coagulation function indexes, the patients in the observation group were divided into study group A (<3 indexes increased or decreased by <30% compared with the normal value) and study group B (≥3 indexes were lower or higher than the normal value by 30%). The levels of coagulation function indexes and prognosis of the two groups at different time points were observed.Results APTT, PT, TT and D-D in the observation group were higher than those in the control group, and AT-Ⅲ and FIB were lower than those in the control group (P<0.05). APTT, PT, TT and D-D in patients with good prognosis were lower than those in patients with disability, while AT-(P<0.05) and FIB were higher than those in patients with disability (P<0.05). There was no significant difference in APTT, TT and FIB between study group A and study group B at admission, 6 h and 24 h after bleeding (P>0.05). At 6 and 24 hours after bleeding, PT and AT-III in the study group A were higher than those in the study group B, and D-D was lower than that in the study group B (P<0.05). The disability and mortality rates of group A were lower than those of group B, and the good rate was higher than that of group B (P<0.05).Conclusion Coagulation function test has important value in the prognosis of patients with cardiovascular and cerebrovascular diseases. Patients with cardiovascular diseases have abnormal coagulation function and poor prognosis. At the same time, the more serious the abnormality of coagulation function indexes, the greater the risk of bleeding, especially the changes of PT, D-D and AT-Ⅲ indexes have certain predictive value for bleeding risk.

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更新日期/Last Update: 1900-01-01