[1]黄德斌,章臻翊,章 婷,等.2型糖尿病患者亚临床甲状腺功能减退与白蛋白尿的关系研究[J].医学信息,2018,31(02):88-90,93.[doi:10.3969/j.issn.1006-1959.2018.02.030]
　HUANG De-bin,ZHANG Zhen-yi,ZHANG Ting,et al.Relationship between Subclinical Hypothyroidism and Albuminuria in Patients with Type 2 Diabetes Mellitus[J].Journal of Medical Information,2018,31(02):88-90,93.[doi:10.3969/j.issn.1006-1959.2018.02.030]
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2型糖尿病患者亚临床甲状腺功能减退与白蛋白尿的关系研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年02期
页码:
88-90,93
栏目:
临床研究
出版日期:
2018-01-15

文章信息/Info

Title:
Relationship between Subclinical Hypothyroidism and Albuminuria in Patients with Type 2 Diabetes Mellitus
文章编号:
1006-1959（2018）02-0089-03
作者:
黄德斌; 章臻翊; 章 婷; 罗亚衡; 岳 星
长沙市第三医院内分泌代谢病科，湖南 长沙 410015
Author(s):
HUANG De-bin; ZHANG Zhen-yi; ZHANG Ting; LUO Ya-heng; YUE Xing
Department of Endocrine and Metabolic Diseases,Third Hospital of Changsha,Changsha 410015,Hunan,China
关键词:
2型糖尿病; 亚临床甲状腺功能减退症; 尿蛋白排泄率
Keywords:
Key words：Type 2 diabetes mellitus; Subclinical hypothyroidism; Urinary protein excretion rate
分类号:
R587
DOI:
10.3969/j.issn.1006-1959.2018.02.030
文献标志码:
A
摘要:
目的 探讨2型糖尿病合并亚临床甲状腺功能减退患者的临床特征，分析SCH与24 h白蛋白尿排泄率的关系。方法 采用回顾性研究方法，选取在我院内分泌科住院的资料完整的826例T2DM患者，分析患者的一般资料、生化指标、甲状腺功能和UAER，同时将SCH患者按蛋白尿分层，比较各组甲状腺功能。采用非条件Logistic多元逐步回归分析SCH与UAER的关系。结果 18.40%的T2DM患者合并SCH，SCH组患者eGFR 较低而UAER较高（P＜0.05），SCH合并蛋白尿组患者FT4下降，TSH升高（P＜0.05）。Logistic回归分析显示，血清TSH水平是UAER 的独立危险因素（r=0.353，P＜0.05）。结论 T2DM合并SCH患者UAER升高，SCH是T2DM患者合并白蛋白尿的独立危险因素。
Abstract:
Abstract：Objective To investigate the clinical characteristics of patients with type 2 diabetes mellitus complicated with subclinical hypothyroidism and the relationship between SCH and 24 h albuminuria excretion rate.Methods A retrospective study was conducted to select 826 T2DM patients with complete data in our hospital for endocrinology.The general data,biochemical indexes,thyroid function and UAER were analyzed.Patients with SCH were stratified by proteinuria and the thyroid function was compared between groups.The relationship between SCH and UAER was analyzed by non-conditional Logistic multiple stepwise regression.Results 18.40% of T2DM patients with SCH,SCH patients with lower eGFR and higher UAER (P<0.05),patients with SCH combined proteinuria FT4 decreased,TSH increased(P<0.05).Logistic regression analysis showed that serum TSH level was an independent risk factor for UAER(r=0.353,P<0.05).Conclusion UAER is elevated in patients with T2DM complicated with SCH,SCH is an independent risk factor for albuminuria in T2DM patients.

参考文献/References:

[1]Han C,He X,Xia X.Subclinical Hypothyroidism and Type 2 Diabetes:A Systematic Review and Meta-Analysis[J].PLoS One,2015,10(8):e0135233.
[2]张冬梅,张莉,郑莹莹等.亚临床甲状腺功能减退与2型糖尿病慢性并发症的关系[J].中国糖尿病杂志,2014,22(1):25-29.
[3]Furukawa S,Yamamoto S,Todo Y.Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus[J].Endocr J,2014,61(10):1011-1018.
[4]葛永纯,谢红浪,徐峰.糖尿病肾病微量白蛋白尿患者肾脏组织损伤及病情变化的研究[J].肾脏病与透析肾移植杂志,2015,24(3):207-212,269.
[5] Qi Q, Zhang QM, Li CJ. Association of Thyroid-Stimulating Hormone Levels with Microvascular Complications in Type 2 Diabetes Patients. Med Sci Monit. 2017 Jun 4;23:2715-2720.
[6]El-Eshmawy MM,Abd El-Hafez HA,El Shabrawy WO.Subclinical hypothyroidism is independently associated with microalbuminuria in a cohort of prediabetic egyptian adults[J].Diabetes Metab J,2013,37(6):450-457.
[7]Palma CC,Pavesi M,Nogueira VG.Prevalence of thyroid dysfunction in patients with diabetes mellitus[J].Diabetol Metab Syndr,2013,5(1):58.

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更新日期/Last Update: 2018-02-15