[1]潘 婷,胡阳黔.Th17细胞在非酒精性脂肪肝病炎症过程中的作用[J].医学信息,2020,33(18):22-25.[doi:10.3969/j.issn.1006-1959.2020.18.007]
 PAN Ting,HU Yang-qian.The Role of Th17 Cells in the Inflammatory Process of Non-alcoholic Fatty Liver Disease[J].Medical Information,2020,33(18):22-25.[doi:10.3969/j.issn.1006-1959.2020.18.007]
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Th17细胞在非酒精性脂肪肝病炎症过程中的作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年18期
页码:
22-25
栏目:
综述
出版日期:
2020-09-15

文章信息/Info

Title:
The Role of Th17 Cells in the Inflammatory Process of Non-alcoholic Fatty Liver Disease
文章编号:
1006-1959(2020)18-0022-04
作者:
潘 婷胡阳黔
(湖北医药学院附属东风医院消化内科,湖北 十堰 442000)
Author(s):
PAN TingHU Yang-qian
(Department of Gastroenterology,Dongfeng Hospital,Hubei Medical College,Shiyan 442000,Hubei,China)
关键词:
Th17细胞炎症因子非酒精性脂肪肝病
Keywords:
Th17 cellsInflammatory factorsNon-alcoholic fatty liver disease
分类号:
R575.5
DOI:
10.3969/j.issn.1006-1959.2020.18.007
文献标志码:
A
摘要:
非酒精性脂肪肝病(NAFLD)是指除外酒精和其他明确的肝脏损害因素所致的、以弥漫性肝细胞大泡性脂肪变为主要特征的一组临床病理综合征,其疾病谱包括单纯性脂肪肝(NAFL)、非酒精性脂肪性肝炎(NASH)、肝纤维化和肝硬化。NAFLD 不仅可以导致残疾和死亡,还与代谢综合征(MetS)、2 型糖尿病(T2DM)、动脉硬化性心血管疾病及结直肠肿瘤等疾病密切相关。近年来,研究发现免疫细胞及细胞因子在NAFLD的发病中发挥重要的作用,包括中性粒细胞、巨噬细胞、树突状细胞、自然杀伤(NK)细胞、NKT细胞、调节性T细胞(Treg)和Th17细胞等,其通过分泌IL-6、IL-21、IL-23、IL-17、TNF-α、TNF-β、CD33等炎症因子作用于NAFLD,本文主要综述Th17细胞在非酒精性脂肪肝病炎症过程中的作用,以便为进一步研究非酒精性脂肪肝病及其治疗提供新的思路。
Abstract:
Non-alcoholic fatty liver disease (NAFLD) refers to a group of clinicopathological syndromes that are mainly characterized by diffuse hepatocyte bullous fat, which is caused by alcohol and other clear liver damage factors, and its disease spectrum includes simple fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), liver fibrosis and cirrhosis. NAFLD can not only cause disability and death, but is also closely related to diseases such as metabolic syndrome (MetS), type 2 diabetes (T2DM), atherosclerotic cardiovascular disease, and colorectal tumors. In recent years, studies have found that immune cells and cytokines play an important role in the pathogenesis of NAFLD, including neutrophils, macrophages, dendritic cells, natural killer (NK) cells, NKT cells, regulatory T cells (Treg) and Th17 cells, etc., It acts on NAFLD by secreting IL-6, IL-21, IL-23, IL-17, TNF-α, TNF-β, CD33 and other inflammatory factors. This article mainly reviews the role of Th17 cells in the inflammatory process of non-alcoholic fatty liver disease. In order to provide new ideas for further research on non-alcoholic fatty liver disease and its treatment.

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更新日期/Last Update: 1900-01-01