[1]单玉梅.尼可地尔联合单硝酸异山梨酯治疗冠心病慢性心力衰竭的疗效[J].医学信息,2021,34(21):153-155.[doi:10.3969/j.issn.1006-1959.2021.21.043]
 SHAN Yu-mei.Effect of Nicorandil Combined with Isosorbide Mononitrate in the Treatment of Coronary Heart Disease with Chronic Heart Failure[J].Medical Information,2021,34(21):153-155.[doi:10.3969/j.issn.1006-1959.2021.21.043]
点击复制

尼可地尔联合单硝酸异山梨酯治疗冠心病慢性心力衰竭的疗效()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年21期
页码:
153-155
栏目:
药物与临床
出版日期:
2021-11-01

文章信息/Info

Title:
Effect of Nicorandil Combined with Isosorbide Mononitrate in the Treatment of Coronary Heart Disease with Chronic Heart Failure
文章编号:
1006-1959(2021)21-0153-03
作者:
单玉梅
(盐城市大丰人民医院药剂科,江苏 盐城 224100)
Author(s):
SHAN Yu-mei
(Department of Pharmacy,Yancheng Dafeng People’s Hospital,Yancheng 224100,Jiangsu,China)
关键词:
尼可地尔冠心病慢性心力衰竭心功能
Keywords:
NicorandilCoronary heart diseaseChronic heart failureHeart function
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2021.21.043
文献标志码:
A
摘要:
目的 探讨尼可地尔联合单硝酸异山梨酯治疗冠心病慢性心力衰竭的疗效。方法 选取2020年1月-12月我院诊治的172例冠心病慢性心力衰竭患者为研究对象,采用随机数字表法分为对照组和观察组,各86例。对照组单用单硝酸异山梨酯分散片治疗,观察组在对照组基础上加用注射用尼可地尔治疗,比较两组临床疗效、心功能指标、心绞痛发生次数、NT-proBN水平以及临床不良反应发生情况。结果 观察组临床治疗总有效率为93.02%,高于对照组的79.07%,差异有统计学意义(P<0.05);观察组LVEF、LVESD高于对照组,LVP、IVS、LVESD、LVEDD均低于对照组,差异有统计学意义(P<0.05);观察组心绞痛发生次数、NT-proBN水平均小于对照组,差异有统计学意义(P<0.05);观察组临床不良反应发生率为5.81%,低于对照组的11.63%,差异有统计学意义(P<0.05)。结论 尼可地尔联合单硝酸异山梨酯治疗冠心病慢性心力衰竭效果确切,可提高临床治疗总有效率,改善心功能指标,减少心绞痛发作次数,且不增加不良反应发生几率。
Abstract:
Objective To investigate the efficacy of nicorandil combined with isosorbide mononitrate in the treatment of coronary heart disease with chronic heart failure.Methods A total of 172 patients with coronary heart disease and chronic heart failure treated in our hospital from January to December 2020 were selected and randomly divided into control group and observation group, 86 cases in each group. The control group was treated with isosorbide mononitrate dispersible tablets alone, and the observation group was treated with nicorandil for injection on the basis of the control group. The clinical efficacy, cardiac function index, frequency of angina pectoris, NT-proBN level and clinical adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 93.02%, which was higher than 79.07% in the control group, and the difference was statistically significant (P<0.05). LVEF, LVESD in the observation group was higher than that in the control group, LVP, IVS, LVESD and LVEDD were lower than those in the control group, the difference was statistically significant (P<0.05). The frequency of angina pectoris and NT-proBN level in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The incidence of clinical adverse reactions in the observation group was 5.81%, which was lower than 11.63% in the control group, and the difference was statistically significant (P<0.05).Conclusion Nicorandil combined with isosorbide mononitrate is effective in the treatment of chronic heart failure of coronary heart disease, which can improve the total effective rate of clinical treatment and cardiac function indexes, reduce the number of angina attacks, and do not increase the probability of adverse reactions.

参考文献/References:

[1]李平.尼可地尔治疗慢性缺血性心肌病患者心力衰竭的临床研究[J].基层医学论坛,2019,23(1):58-59.[2]杨飞飞,张华,李卿慧.尼可地尔联合曲美他嗪治疗老年(高龄)冠心病慢性心力衰竭患者的临床疗效研究[J].吉林医学,2018(8):1450-1453.[3]玄进,张玲,李振勇,等.银杏蜜环口服溶液联合尼可地尔对心绞痛后冠脉微循环障碍患者疗效及NO,血管紧张素Ⅱ,内皮素-1,CRP变化研究[J].辽宁中医药大学学报,2020,22(9):147-150.[4]王静,王爱华,廖荣宏.尼可地尔治疗慢性缺血性心肌病致心力衰竭患者的效果观察[J].临床合理用药杂志,2019,12(14):1-2.[5]田军,陈捷.冠心病合并慢性心力衰竭患者血浆血浆N-末端促生长抑素水平及临床意义[J].中国卫生检验杂志,2020,30(10):1226-1227,1234.[6]陈兰,孟庆香,严明,等.尼可地尔对缺血性心肌病患者心功能及预后的影响[J].中国地方病防治杂志,2017,32(1):45-46.[7]王强,杨晓宇.尼可地尔对缺血性心肌病心力衰竭患者血清CPP、GDF-15表达的影响[J].泰山医学院学报,2018,39(11):1254.[8]姚峰,刘波,刘敏,等.尼可地尔治疗慢性缺血性心肌病患者心力衰竭的临床疗效观察[J].中国临床医生杂志,2016,44(1):30-32.[9]陈航,张育民,李峰.尼可地尔对慢性稳定性冠心病患者经皮冠状动脉介入治疗术术后血管内皮功能及炎症反应的影响[J].中南药学,2015,13(1):108-112.[10]Sizova ZM,Zakharova VL,Kozlova NV,et al.Influence of the Potassium Channels Activator Nicorandil to the Quality of Life in Patients With Ishemic Heart Disease and Stable Angina Pectoris[J].Kardiologiia,2016,56(6):26-31. [11]李传威,孙志军,杨波,等.尼可地尔在缺血性心脏病患者中的疗效研究[J].中国循证心血管医学杂志,2016,8(4):425-427.[12]Fukui Y,Nozawa T,Ihori H,et al.Nicorandil attenuates ischemia reperfusion injury Via inhibition of norepinephrine release from cardiac sympathetic nerve terminals[J].International Heart Journal,2017,58(5):787-793.[13]裴玮娜,谢瑞芹,崔炜,等.曲美他嗪与尼可地尔对经皮冠状动脉介入治疗相关心肌损伤干预作用的比较[J].中国循环杂志,2015(4):256-260.[14]王东霞.曲美他嗪与尼可地尔治疗微血管性心绞痛的疗效对比研究[J].中西医结合心血管病电子杂志,2016(26):41,44.[15]邓翠云,董明慧,孙世博,等.尼可地尔对老年急性非ST段抬高心肌梗死的心脏保护作用[J].中国老年学杂志,2015,34(12):3238-3240.

相似文献/References:

[1]袁 帅,邢晓博,李 晓,等.MTHFR基因多态性与中年男性冠状动脉病变程度的相关研究[J].医学信息,2018,31(03):67.[doi:10.3969/j.issn.1006-1959.2018.03.021]
 YUAN Shuai,XING Xiao-bo,LI Xiao,et al.Association of MTHFR Gene Polymorphism with Coronary Artery Lesions in Middle-aged Men[J].Medical Information,2018,31(21):67.[doi:10.3969/j.issn.1006-1959.2018.03.021]
[2]张挺挺.经股和桡动脉介入治疗冠心病的临床疗效对比[J].医学信息,2018,31(03):114.[doi:10.3969/j.issn.1006-1959.2018.03.038]
 ZHANG Ting-ting.Comparison of Clinical Effects of Interventional Treatment of Coronary Heart Disease by Femoral and Radial Artery[J].Medical Information,2018,31(21):114.[doi:10.3969/j.issn.1006-1959.2018.03.038]
[3]迮艳华.稳心颗粒联合美托洛尔治疗冠心病心律失常的疗效分析[J].医学信息,2018,31(03):139.[doi:10.3969/j.issn.1006-1959.2018.03.049]
 ZE Yan-hua.Therapeutic Effect of Wenxin Granule Combined with Metoprolol on Arrhythmia of Coronary Heart Disease[J].Medical Information,2018,31(21):139.[doi:10.3969/j.issn.1006-1959.2018.03.049]
[4]张 旭.冠心病心绞痛患者进行护理干预的临床效果及 对护理质量影响研究[J].医学信息,2018,31(05):182.[doi:10.3969/j.issn.1006-1959.2018.05.068]
 ZHANG Xu.Clinical Effect of Nursing Intervention in Patients with Angina Pectoris of Coronary Heart Disease and its Influence on Nursing Quality[J].Medical Information,2018,31(21):182.[doi:10.3969/j.issn.1006-1959.2018.05.068]
[5]向明明,赵晓辉.黑龙江省东部地区汉族人群冠心病的危险因素研究[J].医学信息,2018,31(07):122.[doi:10.3969/j.issn.1006-1959.2018.07.041]
 XIANG Ming-ming,ZHAO Xiao-hui.Study on Risk Factors of Coronary Heart Disease in Han Nationality Population in Eastern Heilongjiang Province[J].Medical Information,2018,31(21):122.[doi:10.3969/j.issn.1006-1959.2018.07.041]
[6]王 坤,张永春.血清胆红素水平、单核细胞数、红细胞分布宽度与 冠状动脉病变程度的关系[J].医学信息,2018,31(08):53.[doi:10.3969/j.issn.1006-1959.2018.08.017]
 WANG Kun,ZHANG Yong-chun.Relationship between Serum Bilirubin Level,Monocyte Count,Red Blood Cell Distribution Width and Severity of Coronary Artery Disease[J].Medical Information,2018,31(21):53.[doi:10.3969/j.issn.1006-1959.2018.08.017]
[7]毛红岩.冠状动脉介入治疗冠心病的疗效及 对患者血清炎症因子的影响[J].医学信息,2018,31(10):77.[doi:10.3969/j.issn.1006-1959.2018.10.023]
 MAO Hong-yan.Effect of Coronary Intervention on Coronary Heart Disease and its Influence on Serum Inflammatory Factors[J].Medical Information,2018,31(21):77.[doi:10.3969/j.issn.1006-1959.2018.10.023]
[8]杨锦龙,刘 欢,吕秋菊,等.非糖尿病患者糖化血红蛋白和胰岛素抵抗与 冠状动脉病变程度的相关性研究[J].医学信息,2018,31(10):93.[doi:10.3969/j.issn.1006-1959.2018.10.028]
 YANG Jin-long,LIU Huan,LV Qiu-ju,et al.Correlation between Glycosylated Hemoglobin and Insulin Resistance and Severity of Coronary Artery Disease in Non-diabetic Patients[J].Medical Information,2018,31(21):93.[doi:10.3969/j.issn.1006-1959.2018.10.028]
[9]李 铎,王建华.盐酸曲美他嗪片辅助治疗对冠心病伴心力衰竭患者氧化应激、心肌功能的影响[J].医学信息,2018,31(10):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
 LI Duo,WANG Jian-hua.Effect of Trimetazidine Hydrochloride Tablets Adjuvant Therapy on Oxidative Stress and Myocardial Function in Patients with Coronary Heart Disease Complicated with Heart Failure[J].Medical Information,2018,31(21):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
[10]田跃雷.冠心病介入治疗后再狭窄的中西医防治[J].医学信息,2022,35(09):46.[doi:10.3969/j.issn.1006-1959.2022.09.011]
 TIAN Yue-lei.Prevention and Treatment of Restenosis After Percutaneous Coronary Intervention with Chinese and Western Medicine[J].Medical Information,2022,35(21):46.[doi:10.3969/j.issn.1006-1959.2022.09.011]
[11]朱周圆,刘 芳,李毅然.尼可地尔联合卡维地洛对冠心病心肌缺血患者心率及血压水平的影响[J].医学信息,2022,35(24):136.[doi:10.3969/j.issn.1006-1959.2022.24.028]
 ZHU Zhou-yuan,LIU Fang,LI Yi-ran.Effect of Nicorandil Combined with Carvedilol on Heart Rate and Blood Pressure in Patients with Coronary Heart Disease and Myocardial Ischemia[J].Medical Information,2022,35(21):136.[doi:10.3969/j.issn.1006-1959.2022.24.028]

更新日期/Last Update: 1900-01-01